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Article: Fatal reactivation of chronic hepatitis B virus infection following withdrawal of chemotherapy in lymphoma patients

TitleFatal reactivation of chronic hepatitis B virus infection following withdrawal of chemotherapy in lymphoma patients
Authors
Issue Date1989
Citation
Quarterly Journal Of Medicine, 1989, v. 73 n. 270, p. 911-917 How to Cite?
AbstractFour Chinese patients with non-Hodgkin's lymphoma and asymptomatic chronic hepatitis B infection developed fulminant hepatitis three to four weeks after two to five courses of chemotherapy. One was initially positive for hepatitis B e antigen and three were positive for antibody to HBeAg. They had normal initial serum aminotransferase levels. In all four patients, the hepatic illness appeared to be caused by reactivation of hepatitis B virus replication as evidenced by the appearance of HBV DNA in serum at the onset of hepatitis, seroreversion from anti-HBe to HBeAg positivity, and the absence of other incriminating drugs or viral markers. All died within three weeks after the onset of jaundice. Serum HBV DNA level dropped to undetectable level as the hepatitis progessed. We postulate that potent cytotoxic therapy reactivated HBV replication and permitted widespread infection of hepatocytes. Upon withdrawal of chemotherapy, the immunologic rebound resulted in rapid destruction of infected hepatocytes and massive liver necrosis. Several methods for the prevention of such hepatic reactivation are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/161789
ISSN
1998 Impact Factor: 2.244
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, JYNen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorLin, HJen_US
dc.contributor.authorLok, ASFen_US
dc.contributor.authorLiang, RHSen_US
dc.contributor.authorWu, PCen_US
dc.contributor.authorChan, TKen_US
dc.contributor.authorTodd, Den_US
dc.date.accessioned2012-09-05T05:14:59Z-
dc.date.available2012-09-05T05:14:59Z-
dc.date.issued1989en_US
dc.identifier.citationQuarterly Journal Of Medicine, 1989, v. 73 n. 270, p. 911-917en_US
dc.identifier.issn0033-5622en_US
dc.identifier.urihttp://hdl.handle.net/10722/161789-
dc.description.abstractFour Chinese patients with non-Hodgkin's lymphoma and asymptomatic chronic hepatitis B infection developed fulminant hepatitis three to four weeks after two to five courses of chemotherapy. One was initially positive for hepatitis B e antigen and three were positive for antibody to HBeAg. They had normal initial serum aminotransferase levels. In all four patients, the hepatic illness appeared to be caused by reactivation of hepatitis B virus replication as evidenced by the appearance of HBV DNA in serum at the onset of hepatitis, seroreversion from anti-HBe to HBeAg positivity, and the absence of other incriminating drugs or viral markers. All died within three weeks after the onset of jaundice. Serum HBV DNA level dropped to undetectable level as the hepatitis progessed. We postulate that potent cytotoxic therapy reactivated HBV replication and permitted widespread infection of hepatocytes. Upon withdrawal of chemotherapy, the immunologic rebound resulted in rapid destruction of infected hepatocytes and massive liver necrosis. Several methods for the prevention of such hepatic reactivation are discussed.en_US
dc.languageengen_US
dc.relation.ispartofQuarterly Journal of Medicineen_US
dc.subject.meshAdulten_US
dc.subject.meshAntineoplastic Agents - Adverse Effectsen_US
dc.subject.meshCarrier Stateen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B - Chemically Induced - Microbiology - Mortalityen_US
dc.subject.meshHepatitis B Surface Antigens - Isolation & Purificationen_US
dc.subject.meshHepatitis B E Antigens - Isolation & Purificationen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver - Microbiologyen_US
dc.subject.meshLymphoma, Non-Hodgkin - Drug Therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSubstance Withdrawal Syndromeen_US
dc.subject.meshVirus Replication - Drug Effectsen_US
dc.titleFatal reactivation of chronic hepatitis B virus infection following withdrawal of chemotherapy in lymphoma patientsen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.emailLiang, RHS:rliang@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.identifier.authorityLiang, RHS=rp00345en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2629023-
dc.identifier.scopuseid_2-s2.0-0024443340en_US
dc.identifier.volume73en_US
dc.identifier.issue270en_US
dc.identifier.spage911en_US
dc.identifier.epage917en_US
dc.identifier.isiWOS:A1989AX54800006-
dc.identifier.scopusauthoridLau, JYN=7402446047en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridLin, HJ=7405571292en_US
dc.identifier.scopusauthoridLok, ASF=35379868500en_US
dc.identifier.scopusauthoridLiang, RHS=26643224900en_US
dc.identifier.scopusauthoridWu, PC=7403119323en_US
dc.identifier.scopusauthoridChan, TK=7402687762en_US
dc.identifier.scopusauthoridTodd, D=7201388182en_US

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