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Article: Pituitary vasoactive intestinal peptide regulates prolactin secretion in the hypothyroid rat

TitlePituitary vasoactive intestinal peptide regulates prolactin secretion in the hypothyroid rat
Authors
Issue Date1989
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NEN
Citation
Neuroendocrinology, 1989, v. 50 n. 5, p. 524-528 How to Cite?
AbstractIn this study, we demonstrated that the cell content and basal secretion of vasoactive intestinal peptide (VIP) in primary rat pituitary cell cultures were increased in hypothyroidism. VIP release from hypothyroid pituitary cells in vitro was stimulated by thyrotropin releasing hormone (TRH 10-8 to 10-6 M) and growth hormone (GH)-releasing hormone (GHRH 10-9 to 10-8 M) but not by corticotropin-releasing hormone or luteinizing hormone-releasing hormone in concentrations up to 10-6 M. In the presence of anti-VIP antisera, there was a significant decrease in basal prolactin secretion from cultured hypothyroid pituitary cells (p < 0.005) indicating that VIP exerts a tonic stimulatory effect on prolactin (PRL) secretion. The increment in PRL secretion following TRH was not affected by exposure to anti-VIP indicating that PRL release after TRH is not mediated by VIP at the pituitary level. In contrast to changes in PRL, exposure to anti-VIP had no effect on basal GH secretion, indicating that the PRL changes are hormone specific. Similarly, GHRH-induced GH release was unaffected by VIP immunoneutralization.
Persistent Identifierhttp://hdl.handle.net/10722/161788
ISSN
2015 Impact Factor: 2.583
2015 SCImago Journal Rankings: 1.479
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, KSLen_US
dc.contributor.authorReichlin, Sen_US
dc.date.accessioned2012-09-05T05:14:58Z-
dc.date.available2012-09-05T05:14:58Z-
dc.date.issued1989en_US
dc.identifier.citationNeuroendocrinology, 1989, v. 50 n. 5, p. 524-528en_US
dc.identifier.issn0028-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/161788-
dc.description.abstractIn this study, we demonstrated that the cell content and basal secretion of vasoactive intestinal peptide (VIP) in primary rat pituitary cell cultures were increased in hypothyroidism. VIP release from hypothyroid pituitary cells in vitro was stimulated by thyrotropin releasing hormone (TRH 10-8 to 10-6 M) and growth hormone (GH)-releasing hormone (GHRH 10-9 to 10-8 M) but not by corticotropin-releasing hormone or luteinizing hormone-releasing hormone in concentrations up to 10-6 M. In the presence of anti-VIP antisera, there was a significant decrease in basal prolactin secretion from cultured hypothyroid pituitary cells (p < 0.005) indicating that VIP exerts a tonic stimulatory effect on prolactin (PRL) secretion. The increment in PRL secretion following TRH was not affected by exposure to anti-VIP indicating that PRL release after TRH is not mediated by VIP at the pituitary level. In contrast to changes in PRL, exposure to anti-VIP had no effect on basal GH secretion, indicating that the PRL changes are hormone specific. Similarly, GHRH-induced GH release was unaffected by VIP immunoneutralization.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NENen_US
dc.relation.ispartofNeuroendocrinologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshGrowth Hormone - Secretionen_US
dc.subject.meshGrowth Hormone-Releasing Hormone - Physiologyen_US
dc.subject.meshHypothyroidism - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPituitary Gland - Secretionen_US
dc.subject.meshProlactin - Secretionen_US
dc.subject.meshRadioimmunoassayen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshThyrotropin - Physiologyen_US
dc.subject.meshThyrotropin-Releasing Hormone - Physiologyen_US
dc.subject.meshThyroxine - Physiologyen_US
dc.subject.meshVasoactive Intestinal Peptide - Physiologyen_US
dc.titlePituitary vasoactive intestinal peptide regulates prolactin secretion in the hypothyroid raten_US
dc.typeArticleen_US
dc.identifier.emailLam, KSL:ksllam@hku.hken_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000125275-
dc.identifier.pmid2514393-
dc.identifier.scopuseid_2-s2.0-0024441608en_US
dc.identifier.volume50en_US
dc.identifier.issue5en_US
dc.identifier.spage524en_US
dc.identifier.epage528en_US
dc.identifier.isiWOS:A1989AW32100007-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridLam, KSL=8082870600en_US
dc.identifier.scopusauthoridReichlin, S=16186732300en_US

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