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Article: Fungal peritonitis complicating peritoneal dialysis: Report of 27 cases and review of treatment

TitleFungal peritonitis complicating peritoneal dialysis: Report of 27 cases and review of treatment
Authors
Issue Date1989
Citation
Quarterly Journal Of Medicine, 1989, v. 71 n. 265, p. 407-416 How to Cite?
AbstractThe clinical features, treatment and outcome of 27 cases of fungal peritonitis were studied. Twenty-one cases occurred in patients receiving CAPD and six in patients on intermittent peritoneal dialysis. Twenty-five cases were due to Candida spp., one was due to Trichosporon spp. and in one, both Candida and Trichosporon and an unidentified acid-fast bacillus were isolated. Clinical features of fungal peritonitis and bacterial peritonitis were the same. A direct comparison with patients without fungal peritonitis failed to reveal an increased incidence of diabetes mellitus. However, a history of recent bacterial peritonitis and antibiotic treatment was frequently obtained. We found that the combination of oral ketoconazole and intraperitoneal miconazole is succesful in treating fungal peritonitis complicating peritoneal dialysis but catheter removal and replacement is often necessary. Analysis of the relationship between clinical outcome and various treatment strategies in cases reported in the literature and in our own showed that an initial trial of antifungal drugs consisting of oral ketoconazole and i.p. 5-fluorocytosine or miconazole is warranted in most cases before contemplating catheter removal.
Persistent Identifierhttp://hdl.handle.net/10722/161781
ISSN
1998 Impact Factor: 2.244
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheng, IKPen_US
dc.contributor.authorFang, GXen_US
dc.contributor.authorChan, TMen_US
dc.contributor.authorChan, PCKen_US
dc.contributor.authorChan, MKen_US
dc.date.accessioned2012-09-05T05:14:54Z-
dc.date.available2012-09-05T05:14:54Z-
dc.date.issued1989en_US
dc.identifier.citationQuarterly Journal Of Medicine, 1989, v. 71 n. 265, p. 407-416en_US
dc.identifier.issn0033-5622en_US
dc.identifier.urihttp://hdl.handle.net/10722/161781-
dc.description.abstractThe clinical features, treatment and outcome of 27 cases of fungal peritonitis were studied. Twenty-one cases occurred in patients receiving CAPD and six in patients on intermittent peritoneal dialysis. Twenty-five cases were due to Candida spp., one was due to Trichosporon spp. and in one, both Candida and Trichosporon and an unidentified acid-fast bacillus were isolated. Clinical features of fungal peritonitis and bacterial peritonitis were the same. A direct comparison with patients without fungal peritonitis failed to reveal an increased incidence of diabetes mellitus. However, a history of recent bacterial peritonitis and antibiotic treatment was frequently obtained. We found that the combination of oral ketoconazole and intraperitoneal miconazole is succesful in treating fungal peritonitis complicating peritoneal dialysis but catheter removal and replacement is often necessary. Analysis of the relationship between clinical outcome and various treatment strategies in cases reported in the literature and in our own showed that an initial trial of antifungal drugs consisting of oral ketoconazole and i.p. 5-fluorocytosine or miconazole is warranted in most cases before contemplating catheter removal.en_US
dc.languageengen_US
dc.relation.ispartofQuarterly Journal of Medicineen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAmphotericin B - Therapeutic Useen_US
dc.subject.meshCandidiasis - Drug Therapy - Etiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiconazole - Therapeutic Useen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMycoses - Drug Therapy - Etiologyen_US
dc.subject.meshPeritoneal Dialysis - Adverse Effectsen_US
dc.subject.meshPeritoneal Dialysis, Continuous Ambulatory - Adverse Effectsen_US
dc.subject.meshPeritonitis - Drug Therapy - Etiologyen_US
dc.subject.meshTrichosporonen_US
dc.titleFungal peritonitis complicating peritoneal dialysis: Report of 27 cases and review of treatmenten_US
dc.typeArticleen_US
dc.identifier.emailChan, TM:dtmchan@hku.hken_US
dc.identifier.authorityChan, TM=rp00394en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2602540-
dc.identifier.scopuseid_2-s2.0-0024400659en_US
dc.identifier.volume71en_US
dc.identifier.issue265en_US
dc.identifier.spage407en_US
dc.identifier.epage416en_US
dc.identifier.isiWOS:A1989AB40300004-
dc.identifier.scopusauthoridCheng, IKP=7102537483en_US
dc.identifier.scopusauthoridFang, GX=7201871525en_US
dc.identifier.scopusauthoridChan, TM=7402687700en_US
dc.identifier.scopusauthoridChan, PCK=7403497841en_US
dc.identifier.scopusauthoridChan, MK=7402597821en_US

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