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Article: Reducing meal-stimulated acid secretion versus reducing nocturnal acid secretion for healing of duodenal ulcer

TitleReducing meal-stimulated acid secretion versus reducing nocturnal acid secretion for healing of duodenal ulcer
Authors
Issue Date1989
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116
Citation
Digestive Diseases And Sciences, 1989, v. 34 n. 10, p. 1494-1500 How to Cite?
AbstractBoth meal-stimulated and nocturnal acid secretions have been shown to be abnormally increased in patients with duodenal ulcer. The relative efficacy of an acid-reducing regimen aimed specifically at controlling postprandial acid secretion compared with one that controls nocturnal acid secretion is, however, not known. The endoscopic healing rates at weeks 2, 4, 6, 8, 10, and 12 of three cimetidine regimens with identical total daily dose - bedtime (1200 mg), mealtime (400 mg three times a day with meals), and reference (200 mg three times a day with meals and 600 mg at bedtime) - were compared in a randomized study on 141 patients with endoscopically proven duodenal ulcer. Evaluating endoscopists were blinded to patients' form and duration of treatment and their clinical progress; patients were unaware of the comparative design of the study. Life-table analysis for the 12 weeks of observation revealed that the mealtime regimen resulted in significantly (P < 0.05) better healing rates than either the bedtime or the reference regimen. The differences were accounted for largely by the significantly (P < 0.04) better healing rate at two weeks with the mealtime regimen (68%) than with either the bedtime (47%) or the reference (45%) regimen. These findings indicate that a regimen that aims at controlling meal-stimulated acid secretion achieves a faster healing rate than one that aims at controlling nocturnal acid secretion in the treatment of duodenal ulcer, and they suggest that postprandial acid secretion plays a greater role than nocturnal acid secretion in the pathophysiology of this condition.
Persistent Identifierhttp://hdl.handle.net/10722/161779
ISSN
2015 Impact Factor: 2.516
2015 SCImago Journal Rankings: 0.995
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, SKen_US
dc.contributor.authorHui, WMen_US
dc.contributor.authorNg, MMTen_US
dc.contributor.authorLok, ASFen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorBranicki, Fen_US
dc.contributor.authorLau, WYen_US
dc.contributor.authorPoon, GPen_US
dc.date.accessioned2012-09-05T05:14:53Z-
dc.date.available2012-09-05T05:14:53Z-
dc.date.issued1989en_US
dc.identifier.citationDigestive Diseases And Sciences, 1989, v. 34 n. 10, p. 1494-1500en_US
dc.identifier.issn0163-2116en_US
dc.identifier.urihttp://hdl.handle.net/10722/161779-
dc.description.abstractBoth meal-stimulated and nocturnal acid secretions have been shown to be abnormally increased in patients with duodenal ulcer. The relative efficacy of an acid-reducing regimen aimed specifically at controlling postprandial acid secretion compared with one that controls nocturnal acid secretion is, however, not known. The endoscopic healing rates at weeks 2, 4, 6, 8, 10, and 12 of three cimetidine regimens with identical total daily dose - bedtime (1200 mg), mealtime (400 mg three times a day with meals), and reference (200 mg three times a day with meals and 600 mg at bedtime) - were compared in a randomized study on 141 patients with endoscopically proven duodenal ulcer. Evaluating endoscopists were blinded to patients' form and duration of treatment and their clinical progress; patients were unaware of the comparative design of the study. Life-table analysis for the 12 weeks of observation revealed that the mealtime regimen resulted in significantly (P < 0.05) better healing rates than either the bedtime or the reference regimen. The differences were accounted for largely by the significantly (P < 0.04) better healing rate at two weeks with the mealtime regimen (68%) than with either the bedtime (47%) or the reference (45%) regimen. These findings indicate that a regimen that aims at controlling meal-stimulated acid secretion achieves a faster healing rate than one that aims at controlling nocturnal acid secretion in the treatment of duodenal ulcer, and they suggest that postprandial acid secretion plays a greater role than nocturnal acid secretion in the pathophysiology of this condition.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116en_US
dc.relation.ispartofDigestive Diseases and Sciencesen_US
dc.subject.meshCimetidine - Administration & Dosageen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshDuodenal Ulcer - Drug Therapyen_US
dc.subject.meshEatingen_US
dc.subject.meshEndoscopyen_US
dc.subject.meshGastric Juice - Secretionen_US
dc.subject.meshHumansen_US
dc.subject.meshPatient Complianceen_US
dc.titleReducing meal-stimulated acid secretion versus reducing nocturnal acid secretion for healing of duodenal ulceren_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF01537099-
dc.identifier.pmid2791799-
dc.identifier.scopuseid_2-s2.0-0024397820en_US
dc.identifier.volume34en_US
dc.identifier.issue10en_US
dc.identifier.spage1494en_US
dc.identifier.epage1500en_US
dc.identifier.isiWOS:A1989AU66300002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLam, SK=7402279473en_US
dc.identifier.scopusauthoridHui, WM=7103196477en_US
dc.identifier.scopusauthoridNg, MMT=7202076310en_US
dc.identifier.scopusauthoridLok, ASF=35379868500en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridBranicki, F=7003617514en_US
dc.identifier.scopusauthoridLau, WY=7402933199en_US
dc.identifier.scopusauthoridPoon, GP=24788065400en_US

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