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Article: Persistence of Campylobacter pyloridis despite healing of duodenal ulcer and improvement of accompanying duodenitis and gastritis

TitlePersistence of Campylobacter pyloridis despite healing of duodenal ulcer and improvement of accompanying duodenitis and gastritis
Authors
Issue Date1987
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116
Citation
Digestive Diseases And Sciences, 1987, v. 32 n. 11, p. 1255-1260 How to Cite?
AbstractCampylobacter pyloridis has been associated with antral gastritis and duodenal ulcer. To study the pathogenetic role of these organisms in duodenal ulcer, endoscopic biopsies, two from the first part of duodenum, four from antrum, and four from body and fundus, were taken before and after four weeks of cimetidine treatment (1.2 g/day) from 67 patients with active duodenal ulcer. The biopsies were examined for the presence and severity of any inflammation by two independent pathologists in the absence of any clinical information and for the occurrence and density of Campylobacter pyloridis by culture and Warthin-Starry stain. Before treatment, inflammation was present in 71.1, 100, and 25.8%, while the organisms were present in 34.3, 91.0, and 79.1% of the duodenal, antral, and fundal biopsies, respectively. With complete healing of duodenal ulcer, inflammation was present in 48.9, 98.2, and 30.2%, while the organisms were present in 25, 76,7, and 63.3% of the respective mucosae. With ulcer healing, duodenitis became significantly milder (P <0.0.5). With improvement of gastritis and duodenitis, there was no signiicant change in the occurrence and density of Campylobacter pyloridis. These findings indicate that healing of duodenal ulcer is not influenced by the presence of Campylobacter pyloridis, which is frequently found in the gastroduodenal mucosa of patients with duodenal ulcer, but does not appear to be associated with mucosal inflammation except in the antrum.
Persistent Identifierhttp://hdl.handle.net/10722/161728
ISSN
2015 Impact Factor: 2.516
2015 SCImago Journal Rankings: 0.995
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHui, WMen_US
dc.contributor.authorLam, SKen_US
dc.contributor.authorChau, PYen_US
dc.contributor.authorHo, Jen_US
dc.contributor.authorLui, Ien_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorLok, ASFen_US
dc.contributor.authorNg, MMTen_US
dc.date.accessioned2012-09-05T05:14:25Z-
dc.date.available2012-09-05T05:14:25Z-
dc.date.issued1987en_US
dc.identifier.citationDigestive Diseases And Sciences, 1987, v. 32 n. 11, p. 1255-1260en_US
dc.identifier.issn0163-2116en_US
dc.identifier.urihttp://hdl.handle.net/10722/161728-
dc.description.abstractCampylobacter pyloridis has been associated with antral gastritis and duodenal ulcer. To study the pathogenetic role of these organisms in duodenal ulcer, endoscopic biopsies, two from the first part of duodenum, four from antrum, and four from body and fundus, were taken before and after four weeks of cimetidine treatment (1.2 g/day) from 67 patients with active duodenal ulcer. The biopsies were examined for the presence and severity of any inflammation by two independent pathologists in the absence of any clinical information and for the occurrence and density of Campylobacter pyloridis by culture and Warthin-Starry stain. Before treatment, inflammation was present in 71.1, 100, and 25.8%, while the organisms were present in 34.3, 91.0, and 79.1% of the duodenal, antral, and fundal biopsies, respectively. With complete healing of duodenal ulcer, inflammation was present in 48.9, 98.2, and 30.2%, while the organisms were present in 25, 76,7, and 63.3% of the respective mucosae. With ulcer healing, duodenitis became significantly milder (P <0.0.5). With improvement of gastritis and duodenitis, there was no signiicant change in the occurrence and density of Campylobacter pyloridis. These findings indicate that healing of duodenal ulcer is not influenced by the presence of Campylobacter pyloridis, which is frequently found in the gastroduodenal mucosa of patients with duodenal ulcer, but does not appear to be associated with mucosal inflammation except in the antrum.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116en_US
dc.relation.ispartofDigestive Diseases and Sciencesen_US
dc.subject.meshAdulten_US
dc.subject.meshCampylobacter - Isolation & Purificationen_US
dc.subject.meshCimetidine - Therapeutic Useen_US
dc.subject.meshDuodenal Ulcer - Complications - Drug Therapy - Microbiologyen_US
dc.subject.meshDuodenitis - Complications - Microbiologyen_US
dc.subject.meshDuodenum - Microbiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastric Fundus - Microbiologyen_US
dc.subject.meshGastritis - Complications - Microbiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshPyloric Antrum - Microbiologyen_US
dc.subject.meshWound Healingen_US
dc.titlePersistence of Campylobacter pyloridis despite healing of duodenal ulcer and improvement of accompanying duodenitis and gastritisen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF01296375-
dc.identifier.pmid3665680-
dc.identifier.scopuseid_2-s2.0-0023241850en_US
dc.identifier.volume32en_US
dc.identifier.issue11en_US
dc.identifier.spage1255en_US
dc.identifier.epage1260en_US
dc.identifier.isiWOS:A1987K751000007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHui, WM=7103196477en_US
dc.identifier.scopusauthoridLam, SK=7402279473en_US
dc.identifier.scopusauthoridChau, PY=29267456900en_US
dc.identifier.scopusauthoridHo, J=15029093800en_US
dc.identifier.scopusauthoridLui, I=36951019800en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridLok, ASF=35379868500en_US
dc.identifier.scopusauthoridNg, MMT=7202076310en_US

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