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Article: Hepatitis B virus infection in Chinese families in Hong Kong

TitleHepatitis B virus infection in Chinese families in Hong Kong
Authors
Anna SukFong LokChingLung LaiPuiChee Wu
KeywordsCarrier state
Family
Hepatitis B core antigens
Hepatitis B surface antigens
Hepatitis B virus
Issue Date1987
PublisherOxford University Press. The Journal's web site is located at http://aje.oxfordjournals.org/
Citation
American Journal Of Epidemiology, 1987, v. 126 n. 3, p. 492-499 How to Cite?
DOI: http://dx.doi.org/10.1093/oxfordjournals.aje.a114681
AbstractBetween January 1983 and July 1984, 731 family members of 240 hepatitis B surface antigen (HBsAg) carriers were screened for hepatitis B virus markers. The percentage of those who were positive for HBsAg was 28.3 and that for antibody to hepatitis B surface antigen/antibody to hepatitis B core antigen was 43.1. The carrier rate was higher among siblings (53%) and offspring (50.5%) of female carriers, but similiar to that of the age-matched general population for spouses (10.8%). Maternal transmission was the most important mode of spread of hepatitis B virus infection within the family. The HBsAg-positive offspring and sibling were clustered within certain families. Intrafamilial spread is important in perpetuating hepatitis B virus infection in Chinese persons. Susceptible family members, especially newborns and other young children of female carriers, should be vaccinated.
Persistent Identifierhttp://hdl.handle.net/10722/161725
ISSN
0002-9262
2021 Impact Factor: 5.363
2020 SCImago Journal Rankings: 2.330
ISI Accession Number ID
WOS:A1987J651100015

 

DC FieldValueLanguage
dc.contributor.authorAnna SukFong Loken_US
dc.contributor.authorChingLung Laien_US
dc.contributor.authorPuiChee Wuen_US
dc.date.accessioned2012-09-05T05:14:21Z-
dc.date.available2012-09-05T05:14:21Z-
dc.date.issued1987en_US
dc.identifier.citationAmerican Journal Of Epidemiology, 1987, v. 126 n. 3, p. 492-499en_US
dc.identifier.issn0002-9262en_US
dc.identifier.urihttp://hdl.handle.net/10722/161725-
dc.description.abstractBetween January 1983 and July 1984, 731 family members of 240 hepatitis B surface antigen (HBsAg) carriers were screened for hepatitis B virus markers. The percentage of those who were positive for HBsAg was 28.3 and that for antibody to hepatitis B surface antigen/antibody to hepatitis B core antigen was 43.1. The carrier rate was higher among siblings (53%) and offspring (50.5%) of female carriers, but similiar to that of the age-matched general population for spouses (10.8%). Maternal transmission was the most important mode of spread of hepatitis B virus infection within the family. The HBsAg-positive offspring and sibling were clustered within certain families. Intrafamilial spread is important in perpetuating hepatitis B virus infection in Chinese persons. Susceptible family members, especially newborns and other young children of female carriers, should be vaccinated.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://aje.oxfordjournals.org/en_US
dc.relation.ispartofAmerican Journal of Epidemiologyen_US
dc.subjectCarrier state-
dc.subjectFamily-
dc.subjectHepatitis B core antigens-
dc.subjectHepatitis B surface antigens-
dc.subjectHepatitis B virus-
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCarrier State - Immunologyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B - Epidemiology - Geneticsen_US
dc.subject.meshHepatitis B Antibodies - Analysisen_US
dc.subject.meshHepatitis B Core Antigens - Immunologyen_US
dc.subject.meshHepatitis B Surface Antigens - Analysis - Immunologyen_US
dc.subject.meshHepatitis B E Antigens - Analysis - Immunologyen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRisken_US
dc.subject.meshSex Factorsen_US
dc.subject.meshSpace-Time Clusteringen_US
dc.subject.meshVaccinationen_US
dc.titleHepatitis B virus infection in Chinese families in Hong Kongen_US
dc.typeArticleen_US
dc.identifier.emailChingLung Lai:hrmelcl@hku.hken_US
dc.identifier.authorityChingLung Lai=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/oxfordjournals.aje.a114681-
dc.identifier.pmid3618581-
dc.identifier.scopuseid_2-s2.0-0023202589en_US
dc.identifier.volume126en_US
dc.identifier.issue3en_US
dc.identifier.spage492en_US
dc.identifier.epage499en_US
dc.identifier.isiWOS:A1987J651100015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridAnna SukFong Lok=35379868500en_US
dc.identifier.scopusauthoridChingLung Lai=7403086396en_US
dc.identifier.scopusauthoridPuiChee Wu=7409653811en_US
dc.identifier.issnl0002-9262-

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