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Article: Fifty cases of primary hyperaldosteronism in Hong Kong Chinese with a high frequency of periodic paralysis. Evaluation of techniques for tumour localisation

TitleFifty cases of primary hyperaldosteronism in Hong Kong Chinese with a high frequency of periodic paralysis. Evaluation of techniques for tumour localisation
Authors
Issue Date1986
Citation
Quarterly Journal Of Medicine, 1986, v. 61 n. 235, p. 1021-1037 How to Cite?
AbstractFifty consecutive Chinese patients with primary hyperaldosteronism were studied. All were considered to have an adrenal cortical adenoma, this being proven by surgery in 46 cases. In contrast to other reports, periodic paralysis was a presenting feature in 42 per cent of patients. Other notable symptoms were palpitations (30 per cent) and syncope (12 per cent). Vascular complications were present in 20 per cent of cases. Mean serum potassium level at presentation was 2.1 ± 0.1 (mean ± SEM) and sodium 145.0 ± 0.1 mmol/l. Serum potassium was significantly lower and plasma aldosterone higher in patients with periodic paralysis. Adrenal venography in order to localise the tumour was unreliable and was misleading in two cases. Adrenal venous sampling for steroid analysis was much more helpful, despite the difficulty of obtaining right adrenal venous blood. The side of the adenoma could be predicted in 97 per cent of cases from measurements of left adrenal venous and vena caval aldosterone levels. The use of high resolution CT gave 100 per cent accuracy in all 18 patients who underwent surgery, the smallest detected tumour being 0.8 cm in diameter. Surgery corrected hypokalaemia in all cases, and 37 of the 46 patients required no further antihypertensive treatment.
Persistent Identifierhttp://hdl.handle.net/10722/161715
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMa, JTCen_US
dc.contributor.authorWang, Cen_US
dc.contributor.authorLam, KSLen_US
dc.date.accessioned2012-09-05T05:14:18Z-
dc.date.available2012-09-05T05:14:18Z-
dc.date.issued1986en_US
dc.identifier.citationQuarterly Journal Of Medicine, 1986, v. 61 n. 235, p. 1021-1037en_US
dc.identifier.urihttp://hdl.handle.net/10722/161715-
dc.description.abstractFifty consecutive Chinese patients with primary hyperaldosteronism were studied. All were considered to have an adrenal cortical adenoma, this being proven by surgery in 46 cases. In contrast to other reports, periodic paralysis was a presenting feature in 42 per cent of patients. Other notable symptoms were palpitations (30 per cent) and syncope (12 per cent). Vascular complications were present in 20 per cent of cases. Mean serum potassium level at presentation was 2.1 ± 0.1 (mean ± SEM) and sodium 145.0 ± 0.1 mmol/l. Serum potassium was significantly lower and plasma aldosterone higher in patients with periodic paralysis. Adrenal venography in order to localise the tumour was unreliable and was misleading in two cases. Adrenal venous sampling for steroid analysis was much more helpful, despite the difficulty of obtaining right adrenal venous blood. The side of the adenoma could be predicted in 97 per cent of cases from measurements of left adrenal venous and vena caval aldosterone levels. The use of high resolution CT gave 100 per cent accuracy in all 18 patients who underwent surgery, the smallest detected tumour being 0.8 cm in diameter. Surgery corrected hypokalaemia in all cases, and 37 of the 46 patients required no further antihypertensive treatment.en_US
dc.languageengen_US
dc.relation.ispartofQuarterly Journal of Medicineen_US
dc.subject.meshAdenoma - Complications - Radiography - Surgeryen_US
dc.subject.meshAdrenal Cortex Neoplasms - Complications - Radiography - Surgeryen_US
dc.subject.meshAdulten_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperaldosteronism - Etiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshParalysis - Etiologyen_US
dc.subject.meshTomography, X-Ray Computeden_US
dc.titleFifty cases of primary hyperaldosteronism in Hong Kong Chinese with a high frequency of periodic paralysis. Evaluation of techniques for tumour localisationen_US
dc.typeArticleen_US
dc.identifier.emailLam, KSL:ksllam@hku.hken_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3659246-
dc.identifier.scopuseid_2-s2.0-0023007989en_US
dc.identifier.volume61en_US
dc.identifier.issue235en_US
dc.identifier.spage1021en_US
dc.identifier.epage1037en_US
dc.identifier.isiWOS:A1986F144500005-
dc.identifier.scopusauthoridMa, JTC=24491943700en_US
dc.identifier.scopusauthoridWang, C=7501631357en_US
dc.identifier.scopusauthoridLam, KSL=8082870600en_US

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