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Article: HLA antigens and acetylcholine receptor antibody in the subclassification of myasthenia gravis in Hong Kong Chinese

TitleHLA antigens and acetylcholine receptor antibody in the subclassification of myasthenia gravis in Hong Kong Chinese
Authors
Issue Date1986
PublisherB M J Publishing Group. The Journal's web site is located at http://www.jnnp.com/
Citation
Journal Of Neurology Neurosurgery And Psychiatry, 1986, v. 49 n. 3, p. 316-319 How to Cite?
AbstractThirty seven Chinese adults and 23 children in Hong Kong with myasthenia gravis were tested for HLA-A and -B antigens and acetylcholine receptor (AChR) antibody. HLA BW46 had a significantly increased prevalence in patients with juvenile onset ocular myasthenia gravis. Only one third of the juvenile ocular patients had AChR antibodies and the titres were generally low. In the adult patients taken as a whole there was a non-significant increase in the prevalence of HLA B5 and HLA B15. HLA BW46 was more prevalent in adult patients without AChR antibody and less prevalent in patients with AChR antibody but the findings were not statistically significant. It is suggested that ocular myasthenia gravis is determined by a pathological mechanism for which susceptibility is determined by HLA BW46. There was a strong correlation between ocular myasthenia gravis and Graves' disease in the adult patients. The possibility that ocular myasthenia gravis is accentuated by a BW46-associated predisposition to ocular Graves' disease is considered.
Persistent Identifierhttp://hdl.handle.net/10722/161709
ISSN
2015 Impact Factor: 6.431
2015 SCImago Journal Rankings: 2.913
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHawkins, BRen_US
dc.contributor.authorIp, MSMen_US
dc.contributor.authorLam, KSLen_US
dc.date.accessioned2012-09-05T05:14:14Z-
dc.date.available2012-09-05T05:14:14Z-
dc.date.issued1986en_US
dc.identifier.citationJournal Of Neurology Neurosurgery And Psychiatry, 1986, v. 49 n. 3, p. 316-319en_US
dc.identifier.issn0022-3050en_US
dc.identifier.urihttp://hdl.handle.net/10722/161709-
dc.description.abstractThirty seven Chinese adults and 23 children in Hong Kong with myasthenia gravis were tested for HLA-A and -B antigens and acetylcholine receptor (AChR) antibody. HLA BW46 had a significantly increased prevalence in patients with juvenile onset ocular myasthenia gravis. Only one third of the juvenile ocular patients had AChR antibodies and the titres were generally low. In the adult patients taken as a whole there was a non-significant increase in the prevalence of HLA B5 and HLA B15. HLA BW46 was more prevalent in adult patients without AChR antibody and less prevalent in patients with AChR antibody but the findings were not statistically significant. It is suggested that ocular myasthenia gravis is determined by a pathological mechanism for which susceptibility is determined by HLA BW46. There was a strong correlation between ocular myasthenia gravis and Graves' disease in the adult patients. The possibility that ocular myasthenia gravis is accentuated by a BW46-associated predisposition to ocular Graves' disease is considered.en_US
dc.languageengen_US
dc.publisherB M J Publishing Group. The Journal's web site is located at http://www.jnnp.com/en_US
dc.relation.ispartofJournal of Neurology Neurosurgery and Psychiatryen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAgeden_US
dc.subject.meshAutoantibodies - Analysisen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshHla Antigens - Analysisen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyasthenia Gravis - Classification - Genetics - Immunologyen_US
dc.subject.meshOculomotor Musclesen_US
dc.subject.meshReceptors, Cholinergic - Immunologyen_US
dc.titleHLA antigens and acetylcholine receptor antibody in the subclassification of myasthenia gravis in Hong Kong Chineseen_US
dc.typeArticleen_US
dc.identifier.emailIp, MSM:msmip@hku.hken_US
dc.identifier.emailLam, KSL:ksllam@hku.hken_US
dc.identifier.authorityIp, MSM=rp00347en_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1136/jnnp.49.3.316-
dc.identifier.pmid3958744-
dc.identifier.scopuseid_2-s2.0-0022653153en_US
dc.identifier.volume49en_US
dc.identifier.issue3en_US
dc.identifier.spage316en_US
dc.identifier.epage319en_US
dc.identifier.isiWOS:A1986A444200014-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridHawkins, BR=35944486200en_US
dc.identifier.scopusauthoridIp, MSM=7102423259en_US
dc.identifier.scopusauthoridLam, KSL=8082870600en_US

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