File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Effect of an opiate antagonist on the responses of circulating catecholamines and the renin-aldosterone system to acute sympathetic stimulation by hand-grip in man

TitleEffect of an opiate antagonist on the responses of circulating catecholamines and the renin-aldosterone system to acute sympathetic stimulation by hand-grip in man
Authors
Issue Date1986
Citation
Acta Endocrinologica, 1986, v. 111 n. 2, p. 252-257 How to Cite?
AbstractThe effect of naloxone on the neurohumoral responses to acute sympathetic stimulation by sustained hand-grip in normal man was investigated. Six normal males were studied fasting at 08.30 h, on two occasions at 7-day intervals, with each subject sustaining 30% of his maximal hand-grip on a hand dynamometer for 5 min. Naloxone (8 mg bolus) in 20 ml normal saline, or saline alone, was given 5 min before hand-grip in a randomised double-blind cross-over trial. Blood was sampled for plasma renin activity, serum aldosterone and plasma catecholamines. The study was repeated in the absence of hand-grip. Sustained hand-grip produced significant elevations in mean blood-pressure, circulating adrenaline, noradrenaline and aldosterone. Naloxone, which had no effect on basal catecholamines, plasma renin activity or aldosterone, significantly enhanced the responses in plasma adrenaline, plasma renin activity and serum aldosterone to hand-grip. The increments in blood pressure and noradrenaline were not affected. These results suggest that endogenous opioids modulate the response of the sympathoadrenal and renin-aldosterone systems to acute sympathetic stimulation by a mild stress in man.
Persistent Identifierhttp://hdl.handle.net/10722/161704
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, KSLen_US
dc.contributor.authorGrossman, Aen_US
dc.contributor.authorBouloux, Pen_US
dc.date.accessioned2012-09-05T05:14:12Z-
dc.date.available2012-09-05T05:14:12Z-
dc.date.issued1986en_US
dc.identifier.citationActa Endocrinologica, 1986, v. 111 n. 2, p. 252-257en_US
dc.identifier.issn0001-5598en_US
dc.identifier.urihttp://hdl.handle.net/10722/161704-
dc.description.abstractThe effect of naloxone on the neurohumoral responses to acute sympathetic stimulation by sustained hand-grip in normal man was investigated. Six normal males were studied fasting at 08.30 h, on two occasions at 7-day intervals, with each subject sustaining 30% of his maximal hand-grip on a hand dynamometer for 5 min. Naloxone (8 mg bolus) in 20 ml normal saline, or saline alone, was given 5 min before hand-grip in a randomised double-blind cross-over trial. Blood was sampled for plasma renin activity, serum aldosterone and plasma catecholamines. The study was repeated in the absence of hand-grip. Sustained hand-grip produced significant elevations in mean blood-pressure, circulating adrenaline, noradrenaline and aldosterone. Naloxone, which had no effect on basal catecholamines, plasma renin activity or aldosterone, significantly enhanced the responses in plasma adrenaline, plasma renin activity and serum aldosterone to hand-grip. The increments in blood pressure and noradrenaline were not affected. These results suggest that endogenous opioids modulate the response of the sympathoadrenal and renin-aldosterone systems to acute sympathetic stimulation by a mild stress in man.en_US
dc.languageengen_US
dc.relation.ispartofActa Endocrinologicaen_US
dc.subject.meshAdulten_US
dc.subject.meshAldosterone - Blooden_US
dc.subject.meshBlood Pressure - Drug Effectsen_US
dc.subject.meshClinical Trials As Topicen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshElectrolytes - Blooden_US
dc.subject.meshEpinephrine - Blooden_US
dc.subject.meshHand - Innervation - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshNaloxone - Pharmacologyen_US
dc.subject.meshNorepinephrine - Blooden_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshReceptors, Opioid - Drug Effectsen_US
dc.subject.meshRenin - Blooden_US
dc.subject.meshRenin-Angiotensin System - Drug Effectsen_US
dc.subject.meshSympathetic Nervous System - Drug Effectsen_US
dc.titleEffect of an opiate antagonist on the responses of circulating catecholamines and the renin-aldosterone system to acute sympathetic stimulation by hand-grip in manen_US
dc.typeArticleen_US
dc.identifier.emailLam, KSL:ksllam@hku.hken_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3006414-
dc.identifier.scopuseid_2-s2.0-0022580467en_US
dc.identifier.volume111en_US
dc.identifier.issue2en_US
dc.identifier.spage252en_US
dc.identifier.epage257en_US
dc.identifier.isiWOS:A1986A150200021-
dc.identifier.scopusauthoridLam, KSL=8082870600en_US
dc.identifier.scopusauthoridGrossman, A=35401342800en_US
dc.identifier.scopusauthoridBouloux, P=8783057300en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats