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Article: Response to hepatitis B vaccine in family members of HBsAg carriers

TitleResponse to hepatitis B vaccine in family members of HBsAg carriers
Authors
Issue Date1986
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763
Citation
Journal Of Medical Virology, 1986, v. 19 n. 1, p. 33-39 How to Cite?
AbstractThe family members of HBsAg carriers have an increased risk of hepatitis B virus (HBV) infection. 214 subjects from 98 families with no HBV markers were randomized to receive hepatitis B vaccine: HEVAC B (Institute Pasteur) or GCC VAC (Green Cross Corporation) at 0, 1, and 5 months. Of those who completed the course, 87.8% had an anti-HBs response of > 10 mIU/ml at 6 months. The response rate was similar for both sexes. There was a decrease in response rate and anti-HBs titre with age. The response rate for HEVAC B was 92.5% and GCC VAC 84.3%. The offspring had comparable response to the spouses who were not blood relatives of the index carriers, but this could be related to their younger age. Discriminant analysis showed that a higher anti-HBs titre was associated HEVAC B, younger age, and less direct relationship with the index carrier.
Persistent Identifierhttp://hdl.handle.net/10722/161703
ISSN
2015 Impact Factor: 1.998
2015 SCImago Journal Rankings: 1.015
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLok, SFAen_US
dc.contributor.authorChingLung Laien_US
dc.contributor.authorPuiChee Wuen_US
dc.contributor.authorNg, MTMen_US
dc.date.accessioned2012-09-05T05:14:11Z-
dc.date.available2012-09-05T05:14:11Z-
dc.date.issued1986en_US
dc.identifier.citationJournal Of Medical Virology, 1986, v. 19 n. 1, p. 33-39en_US
dc.identifier.issn0146-6615en_US
dc.identifier.urihttp://hdl.handle.net/10722/161703-
dc.description.abstractThe family members of HBsAg carriers have an increased risk of hepatitis B virus (HBV) infection. 214 subjects from 98 families with no HBV markers were randomized to receive hepatitis B vaccine: HEVAC B (Institute Pasteur) or GCC VAC (Green Cross Corporation) at 0, 1, and 5 months. Of those who completed the course, 87.8% had an anti-HBs response of > 10 mIU/ml at 6 months. The response rate was similar for both sexes. There was a decrease in response rate and anti-HBs titre with age. The response rate for HEVAC B was 92.5% and GCC VAC 84.3%. The offspring had comparable response to the spouses who were not blood relatives of the index carriers, but this could be related to their younger age. Discriminant analysis showed that a higher anti-HBs titre was associated HEVAC B, younger age, and less direct relationship with the index carrier.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763en_US
dc.relation.ispartofJournal of Medical Virologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshCarrier Stateen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B - Genetics - Immunology - Prevention & Controlen_US
dc.subject.meshHepatitis B Antibodies - Analysis - Biosynthesisen_US
dc.subject.meshHepatitis B Surface Antigens - Analysis - Immunologyen_US
dc.subject.meshHepatitis B Vaccinesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshVaccinationen_US
dc.subject.meshViral Hepatitis Vaccines - Immunologyen_US
dc.titleResponse to hepatitis B vaccine in family members of HBsAg carriersen_US
dc.typeArticleen_US
dc.identifier.emailChingLung Lai:hrmelcl@hku.hken_US
dc.identifier.authorityChingLung Lai=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/jmv.1890190106-
dc.identifier.pmid2939197-
dc.identifier.scopuseid_2-s2.0-0022578933en_US
dc.identifier.volume19en_US
dc.identifier.issue1en_US
dc.identifier.spage33en_US
dc.identifier.epage39en_US
dc.identifier.isiWOS:A1986C000800005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLok, SFA=21035019900en_US
dc.identifier.scopusauthoridChingLung Lai=7403086396en_US
dc.identifier.scopusauthoridPuiChee Wu=7409653811en_US
dc.identifier.scopusauthoridNg, MTM=7202076279en_US

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