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Article: Hypothalamic defects in two adult patients with septo-optic dysplasia

TitleHypothalamic defects in two adult patients with septo-optic dysplasia
Authors
Issue Date1986
Citation
Acta Endocrinologica, 1986, v. 112 n. 3, p. 305-309 How to Cite?
AbstractTwo adult patients with unilateral hypoplastic optic nerves, absent septa pellucida and hypopituitarism are described. Patient 1, aged 20, presented with diabetes insipidus due to partial vasopressin deficiency. Patient 2, aged 29, presented with focal epilepsy. Both had short stature. They showed absent growth hormone (GH) response to insulin-hypoglycaemia or glucagon, but responded to 100 μg growth hormone releasing factor (GRF-44) with a rise in circulating GH, suggesting a hypothalamic defect in GH release though a co-existing pituitary defect cannot be excluded. Other hypothalamic-pituitary functions were normal. These two patients probably represent the milder form of the clinical spectrum of septo-optic dysplasia which, with the extensive use of CT brain scans, will be increasingly encountered by physians attending adult patients.
Persistent Identifierhttp://hdl.handle.net/10722/161700
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, KSLen_US
dc.contributor.authorWang, Cen_US
dc.contributor.authorMa, JTCen_US
dc.date.accessioned2012-09-05T05:14:10Z-
dc.date.available2012-09-05T05:14:10Z-
dc.date.issued1986en_US
dc.identifier.citationActa Endocrinologica, 1986, v. 112 n. 3, p. 305-309en_US
dc.identifier.issn0001-5598en_US
dc.identifier.urihttp://hdl.handle.net/10722/161700-
dc.description.abstractTwo adult patients with unilateral hypoplastic optic nerves, absent septa pellucida and hypopituitarism are described. Patient 1, aged 20, presented with diabetes insipidus due to partial vasopressin deficiency. Patient 2, aged 29, presented with focal epilepsy. Both had short stature. They showed absent growth hormone (GH) response to insulin-hypoglycaemia or glucagon, but responded to 100 μg growth hormone releasing factor (GRF-44) with a rise in circulating GH, suggesting a hypothalamic defect in GH release though a co-existing pituitary defect cannot be excluded. Other hypothalamic-pituitary functions were normal. These two patients probably represent the milder form of the clinical spectrum of septo-optic dysplasia which, with the extensive use of CT brain scans, will be increasingly encountered by physians attending adult patients.en_US
dc.languageengen_US
dc.relation.ispartofActa Endocrinologicaen_US
dc.subject.meshAdulten_US
dc.subject.meshBrain - Radiographyen_US
dc.subject.meshHumansen_US
dc.subject.meshHypopituitarism - Congenitalen_US
dc.subject.meshHypothalamo-Hypophyseal System - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOptic Disk - Radiographyen_US
dc.subject.meshOptic Nerve - Abnormalitiesen_US
dc.subject.meshPituitary Function Testsen_US
dc.subject.meshSeptum Pellucidum - Abnormalitiesen_US
dc.subject.meshTomography, X-Ray Computeden_US
dc.titleHypothalamic defects in two adult patients with septo-optic dysplasiaen_US
dc.typeArticleen_US
dc.identifier.emailLam, KSL:ksllam@hku.hken_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3751451-
dc.identifier.scopuseid_2-s2.0-0022515674en_US
dc.identifier.volume112en_US
dc.identifier.issue3en_US
dc.identifier.spage305en_US
dc.identifier.epage309en_US
dc.identifier.isiWOS:A1986D332000001-
dc.identifier.scopusauthoridLam, KSL=8082870600en_US
dc.identifier.scopusauthoridWang, C=7501631357en_US
dc.identifier.scopusauthoridMa, JTC=24491943700en_US

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