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Article: Duodenal ulcer healing by separate reduction of postprandial and nocturnal acid secretions have different pathophysiology

TitleDuodenal ulcer healing by separate reduction of postprandial and nocturnal acid secretions have different pathophysiology
Authors
Issue Date1985
PublisherBMJ Publishing Group. The Journal's web site is located at http://gut.bmjjournals.com/
Citation
Gut, 1985, v. 26 n. 10, p. 1038-1044 How to Cite?
AbstractThe endoscopic healing rates and factors related to healing of two cimetidine regimens designed to reduce respectively postprandial and nocturnal acid secretions were studied in a randomised trial of cimetidine 200 mg tds with meals, vs 600 mg at bedtime, vs 200 mg tds with meals plus 400 mg at bedtime in 246 patients with duodenal ulcer. The respective healing rates were 62.3%, 63.1%, 77.5% at four weeks and 86.6%, 83.3%, 91.2% at eight weeks. The healing rates at four weeks of both meal time and bedtime regimens were inferior (p<0.05) to that of the standard regimen. Analysis of 45 prospectively obtained factors showed that (i) habitual cigarette smoking adversely affected healing with the meal time regimen but not with the others, indicating that its adverse effect disappeared once nocturnal acid secretion was reduced, (ii) habitual use of analgesics impaired and their abstinence favoured healing by both meal time and bedtime regimens but these effects were lost with the standard regimen, suggesting that if analgesics cannot be withdrawn during ulcer treatment, a reduction of both meal time and night time acid secretions should be ensured, (iii) responders with the meal time and bedtime regimens had respectively significantly higher postprandial serum gastrin and higher basal acid output than the corresponding non-responders suggesting that these responders had different pathophysiology, and (iv) high maximal acid output and large ulcers healed less well by any regimen.
Persistent Identifierhttp://hdl.handle.net/10722/161692
ISSN
2015 Impact Factor: 14.921
2015 SCImago Journal Rankings: 6.474
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, SKen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorNg, Men_US
dc.date.accessioned2012-09-05T05:14:01Z-
dc.date.available2012-09-05T05:14:01Z-
dc.date.issued1985en_US
dc.identifier.citationGut, 1985, v. 26 n. 10, p. 1038-1044en_US
dc.identifier.issn0017-5749en_US
dc.identifier.urihttp://hdl.handle.net/10722/161692-
dc.description.abstractThe endoscopic healing rates and factors related to healing of two cimetidine regimens designed to reduce respectively postprandial and nocturnal acid secretions were studied in a randomised trial of cimetidine 200 mg tds with meals, vs 600 mg at bedtime, vs 200 mg tds with meals plus 400 mg at bedtime in 246 patients with duodenal ulcer. The respective healing rates were 62.3%, 63.1%, 77.5% at four weeks and 86.6%, 83.3%, 91.2% at eight weeks. The healing rates at four weeks of both meal time and bedtime regimens were inferior (p<0.05) to that of the standard regimen. Analysis of 45 prospectively obtained factors showed that (i) habitual cigarette smoking adversely affected healing with the meal time regimen but not with the others, indicating that its adverse effect disappeared once nocturnal acid secretion was reduced, (ii) habitual use of analgesics impaired and their abstinence favoured healing by both meal time and bedtime regimens but these effects were lost with the standard regimen, suggesting that if analgesics cannot be withdrawn during ulcer treatment, a reduction of both meal time and night time acid secretions should be ensured, (iii) responders with the meal time and bedtime regimens had respectively significantly higher postprandial serum gastrin and higher basal acid output than the corresponding non-responders suggesting that these responders had different pathophysiology, and (iv) high maximal acid output and large ulcers healed less well by any regimen.en_US
dc.languageengen_US
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://gut.bmjjournals.com/en_US
dc.relation.ispartofGuten_US
dc.subject.meshAdulten_US
dc.subject.meshAnalgesics - Therapeutic Useen_US
dc.subject.meshCimetidine - Administration & Dosage - Therapeutic Useen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshDuodenal Ulcer - Drug Therapy - Physiopathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastric Acid - Secretionen_US
dc.subject.meshGastrins - Blooden_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshSmokingen_US
dc.subject.meshWound Healingen_US
dc.titleDuodenal ulcer healing by separate reduction of postprandial and nocturnal acid secretions have different pathophysiologyen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1136/gut.26.10.1038-
dc.identifier.pmid4054701en_US
dc.identifier.scopuseid_2-s2.0-0022356653en_US
dc.identifier.volume26en_US
dc.identifier.issue10en_US
dc.identifier.spage1038en_US
dc.identifier.epage1044en_US
dc.identifier.isiWOS:A1985ARX6200011-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLam, SK=7402279473en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridNg, M=7202076310en_US

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