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Article: Analysis of linkage between HLA haplotype and susceptibility to Graves' disease in multiple-case Chinese families in Hong Kong

TitleAnalysis of linkage between HLA haplotype and susceptibility to Graves' disease in multiple-case Chinese families in Hong Kong
Authors
Issue Date1985
Citation
Acta Endocrinologica, 1985, v. 110 n. 1, p. 66-69 How to Cite?
AbstractData from 10 Chinese families in Hong Kong with multiple cases of thyrotoxic Graves' disease were analysed to determine whether genes predisposing to Graves' disease are linked to the HLA region. No evidence was obtained in favour of either dominant or recessive inheritance of HLA-linked susceptibility to Graves' disease. Six of 10 affected parent-offspring combinations had haplotypes containing HLA Bw46 which is more than would be expected from the antigen frequency of Bw46 in normal controls. It is concluded that HLA-associated genes play a role in determining disease susceptibility but that other factors are involved in determining disease expression.
Persistent Identifierhttp://hdl.handle.net/10722/161689
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHawkins, BRen_US
dc.contributor.authorMa, JTCen_US
dc.contributor.authorLam, KSLen_US
dc.date.accessioned2012-09-05T05:13:59Z-
dc.date.available2012-09-05T05:13:59Z-
dc.date.issued1985en_US
dc.identifier.citationActa Endocrinologica, 1985, v. 110 n. 1, p. 66-69en_US
dc.identifier.issn0001-5598en_US
dc.identifier.urihttp://hdl.handle.net/10722/161689-
dc.description.abstractData from 10 Chinese families in Hong Kong with multiple cases of thyrotoxic Graves' disease were analysed to determine whether genes predisposing to Graves' disease are linked to the HLA region. No evidence was obtained in favour of either dominant or recessive inheritance of HLA-linked susceptibility to Graves' disease. Six of 10 affected parent-offspring combinations had haplotypes containing HLA Bw46 which is more than would be expected from the antigen frequency of Bw46 in normal controls. It is concluded that HLA-associated genes play a role in determining disease susceptibility but that other factors are involved in determining disease expression.en_US
dc.languageengen_US
dc.relation.ispartofActa Endocrinologicaen_US
dc.subject.meshAdulten_US
dc.subject.meshChilden_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, Dominanten_US
dc.subject.meshGenes, Recessiveen_US
dc.subject.meshGenetic Linkageen_US
dc.subject.meshGraves Disease - Geneticsen_US
dc.subject.meshHla Antigens - Geneticsen_US
dc.subject.meshHaploidyen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPedigreeen_US
dc.titleAnalysis of linkage between HLA haplotype and susceptibility to Graves' disease in multiple-case Chinese families in Hong Kongen_US
dc.typeArticleen_US
dc.identifier.emailLam, KSL:ksllam@hku.hken_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3839962-
dc.identifier.scopuseid_2-s2.0-0021998559en_US
dc.identifier.volume110en_US
dc.identifier.issue1en_US
dc.identifier.spage66en_US
dc.identifier.epage69en_US
dc.identifier.isiWOS:A1985AQK9200013-
dc.identifier.scopusauthoridHawkins, BR=35944486200en_US
dc.identifier.scopusauthoridMa, JTC=24491943700en_US
dc.identifier.scopusauthoridLam, KSL=8082870600en_US

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