File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Factors influencing healing of duodenal ulcer. Control of nocturnal secretion by H2 blockade and characteristics of patients who failed to heal

TitleFactors influencing healing of duodenal ulcer. Control of nocturnal secretion by H2 blockade and characteristics of patients who failed to heal
Authors
Issue Date1985
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116
Citation
Digestive Diseases And Sciences, 1985, v. 30 n. 1, p. 45-51 How to Cite?
AbstractTo study the efficacy of a single bedtime dose of H2-receptor antagonist in the healing of duodenal ulcer, a 12-week randomized double-blind controlled trial of oxmetidine, which is equipotent to cimetidine and has a similar duration of action, was performed in 80 patients. Oxmetidine, 600 mg bedtime, resulted in significantly more complete healing than placebo at weeks 2, 4, 6, 8, 10, and 12 as assessed endoscopically. At weeks 4 and 6, 72.5% and 85%, respectively, of ulcers were completely healed by oxmetidine, and 36.8% and 41.7%, respectively, by placebo. Of 45 prospectively obtained patient characteristics, high pentagastrin-stimulated maximal acid output and large ulcer diameter significantly affected healing adversely. These results indicate that duodenal ulcer healing may be achieved by reducing the nocturnal acid secretion alone.
Persistent Identifierhttp://hdl.handle.net/10722/161687
ISSN
2015 Impact Factor: 2.516
2015 SCImago Journal Rankings: 0.995
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, SKen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorLee, LNWen_US
dc.date.accessioned2012-09-05T05:13:58Z-
dc.date.available2012-09-05T05:13:58Z-
dc.date.issued1985en_US
dc.identifier.citationDigestive Diseases And Sciences, 1985, v. 30 n. 1, p. 45-51en_US
dc.identifier.issn0163-2116en_US
dc.identifier.urihttp://hdl.handle.net/10722/161687-
dc.description.abstractTo study the efficacy of a single bedtime dose of H2-receptor antagonist in the healing of duodenal ulcer, a 12-week randomized double-blind controlled trial of oxmetidine, which is equipotent to cimetidine and has a similar duration of action, was performed in 80 patients. Oxmetidine, 600 mg bedtime, resulted in significantly more complete healing than placebo at weeks 2, 4, 6, 8, 10, and 12 as assessed endoscopically. At weeks 4 and 6, 72.5% and 85%, respectively, of ulcers were completely healed by oxmetidine, and 36.8% and 41.7%, respectively, by placebo. Of 45 prospectively obtained patient characteristics, high pentagastrin-stimulated maximal acid output and large ulcer diameter significantly affected healing adversely. These results indicate that duodenal ulcer healing may be achieved by reducing the nocturnal acid secretion alone.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116en_US
dc.relation.ispartofDigestive Diseases and Sciencesen_US
dc.subject.meshAdulten_US
dc.subject.meshClinical Trials As Topicen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshDuodenal Ulcer - Drug Therapy - Physiopathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastric Juice - Secretionen_US
dc.subject.meshHistamine H2 Antagonists - Pharmacology - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshImidazoles - Adverse Effects - Therapeutic Useen_US
dc.subject.meshMaleen_US
dc.subject.meshPatient Complianceen_US
dc.subject.meshPlacebosen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshWound Healing - Drug Effectsen_US
dc.titleFactors influencing healing of duodenal ulcer. Control of nocturnal secretion by H2 blockade and characteristics of patients who failed to healen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF01318370-
dc.identifier.pmid2856903-
dc.identifier.scopuseid_2-s2.0-0021911317en_US
dc.identifier.volume30en_US
dc.identifier.issue1en_US
dc.identifier.spage45en_US
dc.identifier.epage51en_US
dc.identifier.isiWOS:A1985AAC1800008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLam, SK=7402279473en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridLee, LNW=36984957500en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats