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Article: The diagnostic value of the ratio of serum gamma-glutamyl transpeptidase to alkaline phosphatase in alcoholic liver disease

TitleThe diagnostic value of the ratio of serum gamma-glutamyl transpeptidase to alkaline phosphatase in alcoholic liver disease
Authors
Issue Date1982
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00365521.asp
Citation
Scandinavian Journal Of Gastroenterology, 1982, v. 17 n. 1, p. 41-47 How to Cite?
AbstractA prospective study of the initial liver laboratory tests was carried out in the following patients: 55 patients with alcoholic liver disease, 53 with cholangitis, 41 with hepatocellular carcinoma, 65 with acute viral hepatitis, and 49 with hepatitis-B surface antigen-positive chronic active hepatitis. There was considerable overlap in the levels of the serum gamma-glutamyl transpeptidase (GT) and alkaline phosphatase (AP) among the five groups. However, the ratio of GT to AP was significantly higher in the group with alcoholic liver disease than in any of the other four groups. When the ratio was higher than 1.4, the diagnostic efficiency for distinguishing the alcoholic group from the other four groups was 78% (the normal upper limit for GT and AP being 35 and 115 U/l, respectively). A possible explanation for this higher ratio in alcoholic liver disease is suggested. We conclude that when the GT and AP is greater than 1.4, it is of greater diagnostic value than either variable alone in differentiating alcoholic from other liver diseases.
Persistent Identifierhttp://hdl.handle.net/10722/161664
ISSN
2015 Impact Factor: 2.199
2015 SCImago Journal Rankings: 0.891
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, CLen_US
dc.contributor.authorNg, RPen_US
dc.contributor.authorLok, ASFen_US
dc.date.accessioned2012-09-05T05:13:40Z-
dc.date.available2012-09-05T05:13:40Z-
dc.date.issued1982en_US
dc.identifier.citationScandinavian Journal Of Gastroenterology, 1982, v. 17 n. 1, p. 41-47en_US
dc.identifier.issn0036-5521en_US
dc.identifier.urihttp://hdl.handle.net/10722/161664-
dc.description.abstractA prospective study of the initial liver laboratory tests was carried out in the following patients: 55 patients with alcoholic liver disease, 53 with cholangitis, 41 with hepatocellular carcinoma, 65 with acute viral hepatitis, and 49 with hepatitis-B surface antigen-positive chronic active hepatitis. There was considerable overlap in the levels of the serum gamma-glutamyl transpeptidase (GT) and alkaline phosphatase (AP) among the five groups. However, the ratio of GT to AP was significantly higher in the group with alcoholic liver disease than in any of the other four groups. When the ratio was higher than 1.4, the diagnostic efficiency for distinguishing the alcoholic group from the other four groups was 78% (the normal upper limit for GT and AP being 35 and 115 U/l, respectively). A possible explanation for this higher ratio in alcoholic liver disease is suggested. We conclude that when the GT and AP is greater than 1.4, it is of greater diagnostic value than either variable alone in differentiating alcoholic from other liver diseases.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00365521.aspen_US
dc.relation.ispartofScandinavian Journal of Gastroenterologyen_US
dc.subject.meshAlkaline Phosphatase - Blooden_US
dc.subject.meshCarcinoma, Hepatocellular - Enzymologyen_US
dc.subject.meshCholangitis - Enzymologyen_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshHepatitis B Surface Antigens - Analysisen_US
dc.subject.meshHepatitis, Alcoholic - Enzymologyen_US
dc.subject.meshHepatitis, Viral, Human - Enzymologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Diseases, Alcoholic - Diagnosis - Enzymologyen_US
dc.subject.meshLiver Neoplasms - Enzymologyen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshGamma-Glutamyltransferase - Blooden_US
dc.titleThe diagnostic value of the ratio of serum gamma-glutamyl transpeptidase to alkaline phosphatase in alcoholic liver diseaseen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3109/00365528209181042-
dc.identifier.pmid6127789-
dc.identifier.scopuseid_2-s2.0-0020063156en_US
dc.identifier.volume17en_US
dc.identifier.issue1en_US
dc.identifier.spage41en_US
dc.identifier.epage47en_US
dc.identifier.isiWOS:A1982MY56400009-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridNg, RP=7102153823en_US
dc.identifier.scopusauthoridLok, ASF=35379868500en_US

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