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Article: Metabolism of antithrombin III in cirrhosis and carcinoma of the liver

TitleMetabolism of antithrombin III in cirrhosis and carcinoma of the liver
Authors
Issue Date1981
PublisherPortland Press Ltd. The Journal's web site is located at http://www.clinsci.org/
Citation
Clinical Science, 1981, v. 60 n. 6, p. 681-688 How to Cite?
AbstractThe metabolism of human antithrombin III (ATIII) was studied by using 125I-labelled tracer. The plasma half-life (t 1/2 ) was 2.71±0.26 days in normal subjects and was similar in patients with cirrhosis or primary carcinoma of liver. Patients with cirrhosis had low ATIII levels, decreased intravascular mass, total body mass and decreased absolute catabolic rate, suggesting decreased synthesis. The positive correlation of ATIII level with fractional catabolic rate (K10) indicated that the decreased catabolism might exert a positive inhibition on ATIII production. These abnormalities were more exaggerated in patients with macronodular cirrhosis associated with hepatitis surface antigen or in those with ascites. In cirrhotic patients with ascites an additional extravascular pool of ATIII was present which did not turn over at the same rate as the intravascular pool. Patients with primary carcinoma of liver had moderately low ATIII, but normal intravascular mass and total body mass because of the increased plasma volume and normal absolute catabolic rate. The negative correlation of ATIII levels with K10 suggested that the low levels could be due to increased catabolism or consumption. One patient with disseminated malignancy and active superficial thrombophlebitis and normal ATIII metabolism.
Persistent Identifierhttp://hdl.handle.net/10722/161662
ISSN
2015 Impact Factor: 4.996
2015 SCImago Journal Rankings: 2.427
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, Ven_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorChan, TKen_US
dc.date.accessioned2012-09-05T05:13:40Z-
dc.date.available2012-09-05T05:13:40Z-
dc.date.issued1981en_US
dc.identifier.citationClinical Science, 1981, v. 60 n. 6, p. 681-688en_US
dc.identifier.issn0143-5221en_US
dc.identifier.urihttp://hdl.handle.net/10722/161662-
dc.description.abstractThe metabolism of human antithrombin III (ATIII) was studied by using 125I-labelled tracer. The plasma half-life (t 1/2 ) was 2.71±0.26 days in normal subjects and was similar in patients with cirrhosis or primary carcinoma of liver. Patients with cirrhosis had low ATIII levels, decreased intravascular mass, total body mass and decreased absolute catabolic rate, suggesting decreased synthesis. The positive correlation of ATIII level with fractional catabolic rate (K10) indicated that the decreased catabolism might exert a positive inhibition on ATIII production. These abnormalities were more exaggerated in patients with macronodular cirrhosis associated with hepatitis surface antigen or in those with ascites. In cirrhotic patients with ascites an additional extravascular pool of ATIII was present which did not turn over at the same rate as the intravascular pool. Patients with primary carcinoma of liver had moderately low ATIII, but normal intravascular mass and total body mass because of the increased plasma volume and normal absolute catabolic rate. The negative correlation of ATIII levels with K10 suggested that the low levels could be due to increased catabolism or consumption. One patient with disseminated malignancy and active superficial thrombophlebitis and normal ATIII metabolism.en_US
dc.languageengen_US
dc.publisherPortland Press Ltd. The Journal's web site is located at http://www.clinsci.org/en_US
dc.relation.ispartofClinical Scienceen_US
dc.subject.meshAntithrombin Iii - Metabolismen_US
dc.subject.meshAscites - Metabolismen_US
dc.subject.meshCarcinoma, Hepatocellular - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshHalf-Lifeen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoelectrophoresis, Two-Dimensionalen_US
dc.subject.meshIodine Radioisotopes - Diagnostic Useen_US
dc.subject.meshLiver Cirrhosis - Metabolismen_US
dc.subject.meshLiver Neoplasms - Metabolismen_US
dc.subject.meshMaleen_US
dc.titleMetabolism of antithrombin III in cirrhosis and carcinoma of the liveren_US
dc.typeArticleen_US
dc.identifier.emailChan, V:vnychana@hkucc.hku.hken_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityChan, V=rp00320en_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6265140-
dc.identifier.scopuseid_2-s2.0-0019793627en_US
dc.identifier.volume60en_US
dc.identifier.issue6en_US
dc.identifier.spage681en_US
dc.identifier.epage688en_US
dc.identifier.isiWOS:A1981LS94100011-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChan, V=7202654865en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridChan, TK=7402687762en_US

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