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Article: Clinical features and natural mortality of chronic active hepatitis in Hong Kong

TitleClinical features and natural mortality of chronic active hepatitis in Hong Kong
Authors
Issue Date1981
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IMJ
Citation
Australian And New Zealand Journal Of Medicine, 1981, v. 11 n. 4, p. 354-358 How to Cite?
AbstractTo study the clinical picture and survival of chronic active hepatitis (CAH) in Hong Kong, the records of 298 non-alcoholic patients with histologically proven CAH were reviewed. The male:female ratio was 3.1. The mean age (± SD) on presentation was 47.3 (± 13.1) years. The liver was shrunken and the mean mass (± SD) at autopsy was 887 gm (± 226) compared to 1343 gm (± 172) in cases without liver disease. The spleen was enlarged to 2 to 20 cm below the left costal margin in 98% of cases. The survival graph showed an annual mortality of approximately 13% without a tendency to flatten out within ten years of diagnosis. Survival was best in patients presenting with splenomegaly alone, average in those presenting with ascites or gastrointestinal haemorrhage and worst in those presenting with hepatic decompensation. The modes of death were significantly correlated with the chief complaints on first presentation (P<0.001). The study documented the clinical aspects of CAH in Hong Kong and amplified the differences reported among CAH patients between Australia and Asia.
Persistent Identifierhttp://hdl.handle.net/10722/161659
ISSN
2002 Impact Factor: 0.524
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, KCen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorChan, WCen_US
dc.date.accessioned2012-09-05T05:13:36Z-
dc.date.available2012-09-05T05:13:36Z-
dc.date.issued1981en_US
dc.identifier.citationAustralian And New Zealand Journal Of Medicine, 1981, v. 11 n. 4, p. 354-358en_US
dc.identifier.issn0004-8291en_US
dc.identifier.urihttp://hdl.handle.net/10722/161659-
dc.description.abstractTo study the clinical picture and survival of chronic active hepatitis (CAH) in Hong Kong, the records of 298 non-alcoholic patients with histologically proven CAH were reviewed. The male:female ratio was 3.1. The mean age (± SD) on presentation was 47.3 (± 13.1) years. The liver was shrunken and the mean mass (± SD) at autopsy was 887 gm (± 226) compared to 1343 gm (± 172) in cases without liver disease. The spleen was enlarged to 2 to 20 cm below the left costal margin in 98% of cases. The survival graph showed an annual mortality of approximately 13% without a tendency to flatten out within ten years of diagnosis. Survival was best in patients presenting with splenomegaly alone, average in those presenting with ascites or gastrointestinal haemorrhage and worst in those presenting with hepatic decompensation. The modes of death were significantly correlated with the chief complaints on first presentation (P<0.001). The study documented the clinical aspects of CAH in Hong Kong and amplified the differences reported among CAH patients between Australia and Asia.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IMJen_US
dc.relation.ispartofAustralian and New Zealand Journal of Medicineen_US
dc.subject.meshAdulten_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHepatitis - Complications - Mortalityen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Cirrhosis - Etiologyen_US
dc.subject.meshLiver Diseases - Etiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleClinical features and natural mortality of chronic active hepatitis in Hong Kongen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1445-5994.1981.tb03511.x-
dc.identifier.pmid6946755-
dc.identifier.scopuseid_2-s2.0-0019469198en_US
dc.identifier.volume11en_US
dc.identifier.issue4en_US
dc.identifier.spage354en_US
dc.identifier.epage358en_US
dc.identifier.isiWOS:A1981ME37600003-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridLam, KC=7403657286en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridChan, WC=7403917912en_US

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