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Article: Haemodynamic responses to intravenous cimetidine in subjects with normal lung function and in subjects with chronic airway obstruction

TitleHaemodynamic responses to intravenous cimetidine in subjects with normal lung function and in subjects with chronic airway obstruction
Authors
Issue Date1981
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJCP
Citation
British Journal Of Clinical Pharmacology, 1981, v. 11 n. 4, p. 339-343 How to Cite?
AbstractThe haemodynamic responses to a bolus intravenous injection of 400 mg cimetidine were studied in eight subjects with normal lung function and sixteen with chronic obstructive airway disease (COAD), under continuous systemic and pulmonary arterial monitoring. In all subjects there were significant immediate but transient (less than 10 min) drops in the systemic and pulmonary arterial pressures (both systolic and diastolic), the systemic vascular resistance and total pulmonary resistance. The percentage drops were significantly more marked in the COAD group in the following: systemic arterial pressures (systolic and diastolic), systemic vascular resistance and total pulmonary resistance. The cardiac output showed no significant change in the group with normal lung function but rose significantly in the COAD group. None of the subjects had any symptoms associated with the heamodynamic changes. These results can be explained by a generalized vasodilatory effect of cimetidine, but the relationship to its H 2-receptor blocking effect is undetermined. Hypoxia and/or hypercapnia may sensitize an individual to the vasodilatory effect of cimetidine.
Persistent Identifierhttp://hdl.handle.net/10722/161658
ISSN
2015 Impact Factor: 3.83
2015 SCImago Journal Rankings: 1.486
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, PKen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorLok, ASFen_US
dc.date.accessioned2012-09-05T05:13:36Z-
dc.date.available2012-09-05T05:13:36Z-
dc.date.issued1981en_US
dc.identifier.citationBritish Journal Of Clinical Pharmacology, 1981, v. 11 n. 4, p. 339-343en_US
dc.identifier.issn0306-5251en_US
dc.identifier.urihttp://hdl.handle.net/10722/161658-
dc.description.abstractThe haemodynamic responses to a bolus intravenous injection of 400 mg cimetidine were studied in eight subjects with normal lung function and sixteen with chronic obstructive airway disease (COAD), under continuous systemic and pulmonary arterial monitoring. In all subjects there were significant immediate but transient (less than 10 min) drops in the systemic and pulmonary arterial pressures (both systolic and diastolic), the systemic vascular resistance and total pulmonary resistance. The percentage drops were significantly more marked in the COAD group in the following: systemic arterial pressures (systolic and diastolic), systemic vascular resistance and total pulmonary resistance. The cardiac output showed no significant change in the group with normal lung function but rose significantly in the COAD group. None of the subjects had any symptoms associated with the heamodynamic changes. These results can be explained by a generalized vasodilatory effect of cimetidine, but the relationship to its H 2-receptor blocking effect is undetermined. Hypoxia and/or hypercapnia may sensitize an individual to the vasodilatory effect of cimetidine.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJCPen_US
dc.relation.ispartofBritish Journal of Clinical Pharmacologyen_US
dc.subject.meshAdulten_US
dc.subject.meshCimetidine - Pharmacologyen_US
dc.subject.meshGuanidines - Pharmacologyen_US
dc.subject.meshHemodynamics - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshInjections, Intravenousen_US
dc.subject.meshLung Diseases, Obstructive - Physiopathologyen_US
dc.subject.meshMiddle Ageden_US
dc.titleHaemodynamic responses to intravenous cimetidine in subjects with normal lung function and in subjects with chronic airway obstructionen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2125.1981.tb01130.x-
dc.identifier.pmid7259926-
dc.identifier.scopuseid_2-s2.0-0019462030en_US
dc.identifier.volume11en_US
dc.identifier.issue4en_US
dc.identifier.spage339en_US
dc.identifier.epage343en_US
dc.identifier.isiWOS:A1981LL97000003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLee, PK=8087864700en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridLok, ASF=35379868500en_US

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