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Article: Histologic prognostic indicators in hepatocellular carcinoma

TitleHistologic prognostic indicators in hepatocellular carcinoma
Authors
Issue Date1979
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 1979, v. 44 n. 5, p. 1677-1683 How to Cite?
AbstractSurvival and histologic features were studied in 80 patients with proven hepatocellular carcinoma (HCC). The overall survival was 50% at 3.5 weeks with a statistically significant drop in mortality rate after 8.5 weeks. Patients with diffuse clear-cell pattern, focal clear-cell pattern, and no clear cells in their tumors had a 50% survival rate at 14 weeks, 6 weeks, and 3 weeks respectively; the differences in survival rates were statistically significant between any pair (p<0.001). No correlation was found between survival and (1) cytologic differentiation, (2) histologic architecture, (3) degree of pleomorphism, or (4) presence of bile production, proteinacceous secretion, giant cells, or cytoplasmic hyaline bodies. Eosinophilic HCC with lamellar fibrosis was not observed in any of our materials. We concluded that the presence of clear cells was the only histologic feature of prognostic significance in our patient.
Persistent Identifierhttp://hdl.handle.net/10722/161642
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, CLen_US
dc.contributor.authorWu, PCen_US
dc.contributor.authorLam, KCen_US
dc.contributor.authorTodd, Den_US
dc.date.accessioned2012-09-05T05:13:27Z-
dc.date.available2012-09-05T05:13:27Z-
dc.date.issued1979en_US
dc.identifier.citationCancer, 1979, v. 44 n. 5, p. 1677-1683en_US
dc.identifier.issn0008-543Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/161642-
dc.description.abstractSurvival and histologic features were studied in 80 patients with proven hepatocellular carcinoma (HCC). The overall survival was 50% at 3.5 weeks with a statistically significant drop in mortality rate after 8.5 weeks. Patients with diffuse clear-cell pattern, focal clear-cell pattern, and no clear cells in their tumors had a 50% survival rate at 14 weeks, 6 weeks, and 3 weeks respectively; the differences in survival rates were statistically significant between any pair (p<0.001). No correlation was found between survival and (1) cytologic differentiation, (2) histologic architecture, (3) degree of pleomorphism, or (4) presence of bile production, proteinacceous secretion, giant cells, or cytoplasmic hyaline bodies. Eosinophilic HCC with lamellar fibrosis was not observed in any of our materials. We concluded that the presence of clear cells was the only histologic feature of prognostic significance in our patient.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_US
dc.relation.ispartofCanceren_US
dc.subject.meshCarcinoma, Hepatocellular - Mortality - Pathologyen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Neoplasms - Mortality - Pathologyen_US
dc.subject.meshPrognosisen_US
dc.subject.meshTime Factorsen_US
dc.titleHistologic prognostic indicators in hepatocellular carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/1097-0142(197911)44:5<1677::AID-CNCR2820440522>3.0.CO;2-D-
dc.identifier.pmid227575-
dc.identifier.scopuseid_2-s2.0-0018595752en_US
dc.identifier.volume44en_US
dc.identifier.issue5en_US
dc.identifier.spage1677en_US
dc.identifier.epage1683en_US
dc.identifier.isiWOS:A1979HU19000021-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US
dc.identifier.scopusauthoridWu, PC=7403119323en_US
dc.identifier.scopusauthoridLam, KC=7403657286en_US
dc.identifier.scopusauthoridTodd, D=7201388182en_US

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