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Article: Gastric ulcers with and without associated duodenal ulcer have different pathophysiology

TitleGastric ulcers with and without associated duodenal ulcer have different pathophysiology
Authors
Issue Date1978
PublisherPortland Press Ltd. The Journal's web site is located at http://www.clinsci.org/
Citation
Clinical Science And Molecular Medicine, 1978, v. 55 n. 1, p. 97-102 How to Cite?
AbstractMaximal acid output after pentagastrin stimulation, and fasting and postprandial serum gastrin concentrations was determined in 25 normal subjects, 30 patients with corpus gastric ulcers, 10 patients with prepyloric ulcers and 30 patients with both duodenal and gastric ulcers. Corpus ulcers and prepyloric ulcers formed one distinct group. Maximal acid output was abnormally low in the corpus ulcer patients and no different from normal in prepyloric ulcer patients, whereas fasting serum gastrin and postprandial integrated gastrin response was abnormally high in the former and no different from the normal in the latter. Furthermore, as in the normal subjects, a significant negative correlation between maximal acid output expressed in mmol h -1 kg -1 body weight and postprandial integrated gastrin response was observed in the corpus and prepyloric ulcer patients taken as a group. In complete contrast patients with both duodenal and gastric ulcers, in whom postprandial integrated gastrin response was statistically highest amongst the three types of gastric ulcers, had a significantly positive correlation between maximal acid output and the integrated gastrin response. These findings suggest the operation of different pathophysiological mechanisms in gastric ulcers with and without associated duodenal ulcers.
Persistent Identifierhttp://hdl.handle.net/10722/161635
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, SKen_US
dc.contributor.authorLai, CLen_US
dc.date.accessioned2012-09-05T05:13:23Z-
dc.date.available2012-09-05T05:13:23Z-
dc.date.issued1978en_US
dc.identifier.citationClinical Science And Molecular Medicine, 1978, v. 55 n. 1, p. 97-102en_US
dc.identifier.issn0301-0538en_US
dc.identifier.urihttp://hdl.handle.net/10722/161635-
dc.description.abstractMaximal acid output after pentagastrin stimulation, and fasting and postprandial serum gastrin concentrations was determined in 25 normal subjects, 30 patients with corpus gastric ulcers, 10 patients with prepyloric ulcers and 30 patients with both duodenal and gastric ulcers. Corpus ulcers and prepyloric ulcers formed one distinct group. Maximal acid output was abnormally low in the corpus ulcer patients and no different from normal in prepyloric ulcer patients, whereas fasting serum gastrin and postprandial integrated gastrin response was abnormally high in the former and no different from the normal in the latter. Furthermore, as in the normal subjects, a significant negative correlation between maximal acid output expressed in mmol h -1 kg -1 body weight and postprandial integrated gastrin response was observed in the corpus and prepyloric ulcer patients taken as a group. In complete contrast patients with both duodenal and gastric ulcers, in whom postprandial integrated gastrin response was statistically highest amongst the three types of gastric ulcers, had a significantly positive correlation between maximal acid output and the integrated gastrin response. These findings suggest the operation of different pathophysiological mechanisms in gastric ulcers with and without associated duodenal ulcers.en_US
dc.languageengen_US
dc.publisherPortland Press Ltd. The Journal's web site is located at http://www.clinsci.org/en_US
dc.relation.ispartofClinical Science and Molecular Medicineen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshDuodenal Ulcer - Blood - Complications - Physiopathologyen_US
dc.subject.meshFastingen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastric Juice - Secretionen_US
dc.subject.meshGastrins - Blooden_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSecretory Rateen_US
dc.subject.meshStomach Ulcer - Blood - Complications - Physiopathologyen_US
dc.titleGastric ulcers with and without associated duodenal ulcer have different pathophysiologyen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid668272en_US
dc.identifier.scopuseid_2-s2.0-0018148721en_US
dc.identifier.volume55en_US
dc.identifier.issue1en_US
dc.identifier.spage97en_US
dc.identifier.epage102en_US
dc.identifier.isiWOS:A1978FG02700013-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLam, SK=7402279473en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US

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