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Article: Isoprinosine in classical acute viral hepatitis

TitleIsoprinosine in classical acute viral hepatitis
Authors
Issue Date1978
Citation
American Journal Of Digestive Diseases, 1978, v. 23 n. 10, p. 893-896 How to Cite?
AbstractA prospective double-blind controlled study was performed on the effects of isoprinosine in 81 patients with clinical and histological features of classical acute viral hepatitis. Appetite was assessed daily. Serum alanine aminotransferase, aspartic aminotransferase, and bilirubin levels were assessed weekly. Changes in biochemical parameters, number of deaths, number of patients showing rise of aminotransferase levels despite treatment, and duration required for appetite to return to normal in each group were compared. Observation was continued for 4 weeks. Contrary to preliminary reports, no therapeutic benefit was demonstrated in any of these parameters. We concluded that isoprinosine was ineffective in the acute phase of classical acute viral hepatitis.
Persistent Identifierhttp://hdl.handle.net/10722/161633
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, KCen_US
dc.contributor.authorLin, HJen_US
dc.contributor.authorLai, CLen_US
dc.date.accessioned2012-09-05T05:13:22Z-
dc.date.available2012-09-05T05:13:22Z-
dc.date.issued1978en_US
dc.identifier.citationAmerican Journal Of Digestive Diseases, 1978, v. 23 n. 10, p. 893-896en_US
dc.identifier.issn0002-9211en_US
dc.identifier.urihttp://hdl.handle.net/10722/161633-
dc.description.abstractA prospective double-blind controlled study was performed on the effects of isoprinosine in 81 patients with clinical and histological features of classical acute viral hepatitis. Appetite was assessed daily. Serum alanine aminotransferase, aspartic aminotransferase, and bilirubin levels were assessed weekly. Changes in biochemical parameters, number of deaths, number of patients showing rise of aminotransferase levels despite treatment, and duration required for appetite to return to normal in each group were compared. Observation was continued for 4 weeks. Contrary to preliminary reports, no therapeutic benefit was demonstrated in any of these parameters. We concluded that isoprinosine was ineffective in the acute phase of classical acute viral hepatitis.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Digestive Diseasesen_US
dc.subject.meshAlanine Transaminase - Blooden_US
dc.subject.meshAspartate Aminotransferases - Blooden_US
dc.subject.meshBilirubin - Blooden_US
dc.subject.meshClinical Trials As Topicen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshHepatitis, Viral, Human - Drug Therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshInosine - Analogs & Derivativesen_US
dc.subject.meshInosine Pranobex - Therapeutic Useen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshTransaminases - Blooden_US
dc.titleIsoprinosine in classical acute viral hepatitisen_US
dc.typeArticleen_US
dc.identifier.emailLai, CL:hrmelcl@hku.hken_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF01072462-
dc.identifier.pmid82401-
dc.identifier.scopuseid_2-s2.0-0018137048en_US
dc.identifier.volume23en_US
dc.identifier.issue10en_US
dc.identifier.spage893en_US
dc.identifier.epage896en_US
dc.identifier.isiWOS:A1978FT58000007-
dc.identifier.scopusauthoridLam, KC=7403657286en_US
dc.identifier.scopusauthoridLin, HJ=7405571292en_US
dc.identifier.scopusauthoridLai, CL=7403086396en_US

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