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Book Chapter: Metabolic reprogramming under microaerobic and anaerobic conditions in bacteria

TitleMetabolic reprogramming under microaerobic and anaerobic conditions in bacteria
Authors
Issue Date2012
PublisherSpringer
Citation
Metabolic reprogramming under microaerobic and anaerobic conditions in bacteria. In Wang, X ... (Eds.)(et al), Reprogramming microbial metabolic pathways , p. 159-179. Dordrecht: Springer, 2012 How to Cite?
AbstractOxygen has a great impact on the metabolism and physiology of microorganisms. It serves as the most efficient terminal electron acceptor to drive the energy conservation process of cellular respiration and is required in many biosynthetic reactions. Bacteria encounter oxygen fluctuation and limitation during their growth in both natural ecological niches and in laboratory vessels. In response to oxygen limitation, facultative bacteria undergo substantial metabolic reprogramming to switch from the aerobic respiration to either anaerobic respiration, fermentation, or photosynthesis. Two key factors determine the metabolic pathways bacteria adopt under oxygen deprived microaerobic and anaerobic conditions: maximal energy conservation and redox homeostasis. In this chapter, we first describe how the fulfillment of these two key factors governs the metabolic reprogramming of facultative bacteria and how the process is tightly controlled by several global regulatory factors: FNR, ArcBA, as well as NarL and NarP. We then utilizes fermentation of glycerol, a large surplus byproduct of biodiesel industry, as an example to illustrate how environment, process, and strain based approaches can be exploited to manipulate and engineer the anaerobic metabolic pathways so that desirable fermentation products can be achieved with optimal yield.
Persistent Identifierhttp://hdl.handle.net/10722/160582
ISBN

 

DC FieldValueLanguage
dc.contributor.authorShan, Yen_US
dc.contributor.authorLai, Yen_US
dc.contributor.authorYan, Aen_US
dc.date.accessioned2012-08-16T06:14:46Z-
dc.date.available2012-08-16T06:14:46Z-
dc.date.issued2012en_US
dc.identifier.citationMetabolic reprogramming under microaerobic and anaerobic conditions in bacteria. In Wang, X ... (Eds.)(et al), Reprogramming microbial metabolic pathways , p. 159-179. Dordrecht: Springer, 2012en_US
dc.identifier.isbn9789400750548-
dc.identifier.urihttp://hdl.handle.net/10722/160582-
dc.description.abstractOxygen has a great impact on the metabolism and physiology of microorganisms. It serves as the most efficient terminal electron acceptor to drive the energy conservation process of cellular respiration and is required in many biosynthetic reactions. Bacteria encounter oxygen fluctuation and limitation during their growth in both natural ecological niches and in laboratory vessels. In response to oxygen limitation, facultative bacteria undergo substantial metabolic reprogramming to switch from the aerobic respiration to either anaerobic respiration, fermentation, or photosynthesis. Two key factors determine the metabolic pathways bacteria adopt under oxygen deprived microaerobic and anaerobic conditions: maximal energy conservation and redox homeostasis. In this chapter, we first describe how the fulfillment of these two key factors governs the metabolic reprogramming of facultative bacteria and how the process is tightly controlled by several global regulatory factors: FNR, ArcBA, as well as NarL and NarP. We then utilizes fermentation of glycerol, a large surplus byproduct of biodiesel industry, as an example to illustrate how environment, process, and strain based approaches can be exploited to manipulate and engineer the anaerobic metabolic pathways so that desirable fermentation products can be achieved with optimal yield.-
dc.languageengen_US
dc.publisherSpringer-
dc.relation.ispartofReprogramming microbial metabolic pathwaysen_US
dc.titleMetabolic reprogramming under microaerobic and anaerobic conditions in bacteriaen_US
dc.typeBook_Chapteren_US
dc.identifier.emailYan, A: ayan8@hku.hken_US
dc.identifier.authorityYan, A=rp00823en_US
dc.identifier.doi10.1007/978-94-007-5055-5_8-
dc.identifier.hkuros203633en_US
dc.identifier.spage159-
dc.identifier.epage179-
dc.publisher.placeDordrecht-
dc.customcontrol.immutableyiu 130904-

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