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Conference Paper: The role of regulatory B cells during the progression of human hepatocellular carcinoma
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TitleThe role of regulatory B cells during the progression of human hepatocellular carcinoma
 
AuthorsShao, Y
Li, C
Ma, YY
Liu, X
Chu, CY
Ling, C
Yeung, WH
Lee, KW
Fan, ST
Lo, CM
Man, K
 
Issue Date2012
 
PublisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org
 
CitationJournal of Immunology, v. 188 meeting abstract suppl., abstract 162.39 [How to Cite?]
 
AbstractHong Kong Human regulatory B cells (hBregs) have been shown to play an important role in autoimmune diseases, but their function during human cancer progression remains elusive. In this study, we aim to unveil the underlying mechanism of hBregs regulating human hepatocellular carcinoma (HCC) growth. B cells in HCC liver tumor were examined by immunohistochemistry. We found a tendency that the amount of B cells increased with HCC progression (p=0.001), and it’s in the marginal region of HCC increased (P<0.001) more dramatically. In vitro, human HCC cell line MHCC-97L cells were cocultured with hBregs. hBregs promoted HCC cells proliferation (P=0.011) and migration (p=0.006) and decreased HCC cells apoptosis (p=0.078). HCC cells also promoted hBregs proliferation and migration (p=0.003). hBregs could interact with HCC cells directly through CD40-CD154 signaling. Tail vein injection of hBreg cells into SCID mice increased the size of HCC xenograft tumor (4 weeks, p=0.0221). In vivo imagining showed that hBreg cells could migrate into tumor. Our findings indicate that hBregs could promote HCC progression.
 
DescriptionOpen Access Journal
 
ISSN0022-1767
2012 Impact Factor: 5.52
2012 SCImago Journal Rankings: 3.170
 
DC FieldValue
dc.contributor.authorShao, Y
 
dc.contributor.authorLi, C
 
dc.contributor.authorMa, YY
 
dc.contributor.authorLiu, X
 
dc.contributor.authorChu, CY
 
dc.contributor.authorLing, C
 
dc.contributor.authorYeung, WH
 
dc.contributor.authorLee, KW
 
dc.contributor.authorFan, ST
 
dc.contributor.authorLo, CM
 
dc.contributor.authorMan, K
 
dc.date.accessioned2012-08-16T06:09:36Z
 
dc.date.available2012-08-16T06:09:36Z
 
dc.date.issued2012
 
dc.description.abstractHong Kong Human regulatory B cells (hBregs) have been shown to play an important role in autoimmune diseases, but their function during human cancer progression remains elusive. In this study, we aim to unveil the underlying mechanism of hBregs regulating human hepatocellular carcinoma (HCC) growth. B cells in HCC liver tumor were examined by immunohistochemistry. We found a tendency that the amount of B cells increased with HCC progression (p=0.001), and it’s in the marginal region of HCC increased (P<0.001) more dramatically. In vitro, human HCC cell line MHCC-97L cells were cocultured with hBregs. hBregs promoted HCC cells proliferation (P=0.011) and migration (p=0.006) and decreased HCC cells apoptosis (p=0.078). HCC cells also promoted hBregs proliferation and migration (p=0.003). hBregs could interact with HCC cells directly through CD40-CD154 signaling. Tail vein injection of hBreg cells into SCID mice increased the size of HCC xenograft tumor (4 weeks, p=0.0221). In vivo imagining showed that hBreg cells could migrate into tumor. Our findings indicate that hBregs could promote HCC progression.
 
dc.description.naturelink_to_OA_fulltext
 
dc.descriptionOpen Access Journal
 
dc.identifier.citationJournal of Immunology, v. 188 meeting abstract suppl., abstract 162.39 [How to Cite?]
 
dc.identifier.hkuros202992
 
dc.identifier.issn0022-1767
2012 Impact Factor: 5.52
2012 SCImago Journal Rankings: 3.170
 
dc.identifier.issuemeeting abstract suppl.
 
dc.identifier.urihttp://hdl.handle.net/10722/160393
 
dc.identifier.volume188
 
dc.languageeng
 
dc.publisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Immunology
 
dc.titleThe role of regulatory B cells during the progression of human hepatocellular carcinoma
 
dc.typeConference_Paper
 
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<contributor.author>Chu, CY</contributor.author>
<contributor.author>Ling, C</contributor.author>
<contributor.author>Yeung, WH</contributor.author>
<contributor.author>Lee, KW</contributor.author>
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