Conference Paper: The role of regulatory B cells during the progression of human hepatocellular carcinoma

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TitleThe role of regulatory B cells during the progression of human hepatocellular carcinoma
AuthorsShao, Y
Li, C
Ma, YY
Liu, X
Chu, CY
Ling, C
Yeung, WH
Lee, KW
Fan, ST
Lo, CM
Man, K
Issue Date2012
PublisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org
CitationJournal of Immunology, v. 188 meeting abstract suppl., abstract 162.39 [How to Cite?]
AbstractHong Kong Human regulatory B cells (hBregs) have been shown to play an important role in autoimmune diseases, but their function during human cancer progression remains elusive. In this study, we aim to unveil the underlying mechanism of hBregs regulating human hepatocellular carcinoma (HCC) growth. B cells in HCC liver tumor were examined by immunohistochemistry. We found a tendency that the amount of B cells increased with HCC progression (p=0.001), and it’s in the marginal region of HCC increased (P<0.001) more dramatically. In vitro, human HCC cell line MHCC-97L cells were cocultured with hBregs. hBregs promoted HCC cells proliferation (P=0.011) and migration (p=0.006) and decreased HCC cells apoptosis (p=0.078). HCC cells also promoted hBregs proliferation and migration (p=0.003). hBregs could interact with HCC cells directly through CD40-CD154 signaling. Tail vein injection of hBreg cells into SCID mice increased the size of HCC xenograft tumor (4 weeks, p=0.0221). In vivo imagining showed that hBreg cells could migrate into tumor. Our findings indicate that hBregs could promote HCC progression.
DescriptionOpen Access Journal
ISSN0022-1767
2011 Impact Factor: 5.788
2011 SCImago Journal Rankings: 1.099
DC Field
Value
dc.contributor.authorShao, Y
dc.contributor.authorLi, C
dc.contributor.authorMa, YY
dc.contributor.authorLiu, X
dc.contributor.authorChu, CY
dc.contributor.authorLing, C
dc.contributor.authorYeung, WH
dc.contributor.authorLee, KW
dc.contributor.authorFan, ST
dc.contributor.authorLo, CM
dc.contributor.authorMan, K
dc.date.accessioned2012-08-16T06:09:36Z
dc.date.available2012-08-16T06:09:36Z
dc.date.issued2012
dc.description.abstractHong Kong Human regulatory B cells (hBregs) have been shown to play an important role in autoimmune diseases, but their function during human cancer progression remains elusive. In this study, we aim to unveil the underlying mechanism of hBregs regulating human hepatocellular carcinoma (HCC) growth. B cells in HCC liver tumor were examined by immunohistochemistry. We found a tendency that the amount of B cells increased with HCC progression (p=0.001), and it’s in the marginal region of HCC increased (P<0.001) more dramatically. In vitro, human HCC cell line MHCC-97L cells were cocultured with hBregs. hBregs promoted HCC cells proliferation (P=0.011) and migration (p=0.006) and decreased HCC cells apoptosis (p=0.078). HCC cells also promoted hBregs proliferation and migration (p=0.003). hBregs could interact with HCC cells directly through CD40-CD154 signaling. Tail vein injection of hBreg cells into SCID mice increased the size of HCC xenograft tumor (4 weeks, p=0.0221). In vivo imagining showed that hBreg cells could migrate into tumor. Our findings indicate that hBregs could promote HCC progression.
dc.description.naturelink_to_OA_fulltext
dc.descriptionOpen Access Journal
dc.identifier.citationJournal of Immunology, v. 188 meeting abstract suppl., abstract 162.39 [How to Cite?]
dc.identifier.hkuros202992
dc.identifier.issn0022-1767
2011 Impact Factor: 5.788
2011 SCImago Journal Rankings: 1.099
dc.identifier.issuemeeting abstract suppl.
dc.identifier.urihttp://hdl.handle.net/10722/160393
dc.identifier.volume188
dc.languageeng
dc.publisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Immunology
dc.titleThe role of regulatory B cells during the progression of human hepatocellular carcinoma
dc.typeConference_Paper