File Download
  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL
Supplementary

Conference Paper: Impact of a low-glucose peritoneal dialysis regimen on inflammatory and fibrotic mediators in effluent dialysate

TitleImpact of a low-glucose peritoneal dialysis regimen on inflammatory and fibrotic mediators in effluent dialysate
Authors
Issue Date2011
PublisherAmerican Society of Nephrology. The Journal's web site is located at http://www.jasn.org
Citation
Kidney Week 2011 - The 44th Annual Meeting of the American Society of Nephrology, Philadelphia, PA., 8-13 November 2011. In Journal of the American Society of Nephrology, 2011 meeting abstracts, p. 735A , SA-PO2674 How to Cite?
AbstractBACKGROUND: Constant exposure of the peritoneum to bio-incompatible peritoneal dialysis fluids (PDF) results in deleterious changes to the peritoneal structure and function, which leads to technique failure and unfavorable clinical outcomes. While low-glucose PDF may have improved biocompatibility compared with conventional glucose based dialysates, their impact on biomarkers of inflammation, fibrosis and peritoneal membrane integrity remains to be investigated. METHODS: New PD patients who had entered the PD programme within 1 month were randomized to receive either a low-glucose regimen (1 exchange of Nutrineal®, 2-3 exchanges of Physioneal® and 1 overnight exchange of Extraneal®) for 12 months and then Dianeal® for 6 months (PEN Group, n=43), or 3 to 4 exchanges of Dianeal® for 18 months (Control Group, n=37). Overnight PDF was collected from all patients for the assessment of CA125, and inflammatory and fibrotic markers. RESULTS: Patients in the PEN Group showed a progressive increase in dialysate CA125 level, which was significantly higher than that in Controls after 12 months treatment [mean (range): 56.50 (16.00-166.00) IU/ml vs 20.50 (1.00-84.00) IU/ml, PEN vs Control, P<0.01)], and which reverted after switching back to Dianeal®. Similarly, dialysate levels of decorin, MMP-9, adiponectin, ICAM and VCAM were 1.35-, 2.52-, 1.79-, 1.93- and 1.59-folds respectively higher in the PEN Group compared to Controls after 12 months, but the two groups showed similar levels after the PEN Group changed back to Dianeal®. In contrast, dialysate MIF level was significantly lower in the PEN Group during the first 12 months [0.46 (0.06-1.22) pg/ml vs 0.77 (0.00-1.95) pg/ml, P<0.05], but was comparable between the two groups at 18 months. CONCLUSIONS: Our data demonstrate that the low-glucose dialysis regimen is associated with reduced intra-peritoneal inflammatory and fibrotic response, and thus potentially result in better preservation of the structural and functional property of the peritoneum during long-term peritoneal dialysis.
DescriptionDialysis: Epidemiology, Outcomes, and Clinical Trials: Non-Cardiovascular - III (Poster): SA-PO2674
Abstract Supplement of JASN is located at http://www.asn-online.org/education/kidneyweek/archives/
Persistent Identifierhttp://hdl.handle.net/10722/160346
ISSN
2015 Impact Factor: 8.491
2015 SCImago Journal Rankings: 4.699

 

DC FieldValueLanguage
dc.contributor.authorYung, Sen_US
dc.contributor.authorNg, Cen_US
dc.contributor.authorYim, Aen_US
dc.contributor.authorMa, Men_US
dc.contributor.authorLui, SLen_US
dc.contributor.authorChan, DTMen_US
dc.date.accessioned2012-08-16T06:08:09Z-
dc.date.available2012-08-16T06:08:09Z-
dc.date.issued2011en_US
dc.identifier.citationKidney Week 2011 - The 44th Annual Meeting of the American Society of Nephrology, Philadelphia, PA., 8-13 November 2011. In Journal of the American Society of Nephrology, 2011 meeting abstracts, p. 735A , SA-PO2674en_US
dc.identifier.issn1046-6673-
dc.identifier.urihttp://hdl.handle.net/10722/160346-
dc.descriptionDialysis: Epidemiology, Outcomes, and Clinical Trials: Non-Cardiovascular - III (Poster): SA-PO2674-
dc.descriptionAbstract Supplement of JASN is located at http://www.asn-online.org/education/kidneyweek/archives/-
dc.description.abstractBACKGROUND: Constant exposure of the peritoneum to bio-incompatible peritoneal dialysis fluids (PDF) results in deleterious changes to the peritoneal structure and function, which leads to technique failure and unfavorable clinical outcomes. While low-glucose PDF may have improved biocompatibility compared with conventional glucose based dialysates, their impact on biomarkers of inflammation, fibrosis and peritoneal membrane integrity remains to be investigated. METHODS: New PD patients who had entered the PD programme within 1 month were randomized to receive either a low-glucose regimen (1 exchange of Nutrineal®, 2-3 exchanges of Physioneal® and 1 overnight exchange of Extraneal®) for 12 months and then Dianeal® for 6 months (PEN Group, n=43), or 3 to 4 exchanges of Dianeal® for 18 months (Control Group, n=37). Overnight PDF was collected from all patients for the assessment of CA125, and inflammatory and fibrotic markers. RESULTS: Patients in the PEN Group showed a progressive increase in dialysate CA125 level, which was significantly higher than that in Controls after 12 months treatment [mean (range): 56.50 (16.00-166.00) IU/ml vs 20.50 (1.00-84.00) IU/ml, PEN vs Control, P<0.01)], and which reverted after switching back to Dianeal®. Similarly, dialysate levels of decorin, MMP-9, adiponectin, ICAM and VCAM were 1.35-, 2.52-, 1.79-, 1.93- and 1.59-folds respectively higher in the PEN Group compared to Controls after 12 months, but the two groups showed similar levels after the PEN Group changed back to Dianeal®. In contrast, dialysate MIF level was significantly lower in the PEN Group during the first 12 months [0.46 (0.06-1.22) pg/ml vs 0.77 (0.00-1.95) pg/ml, P<0.05], but was comparable between the two groups at 18 months. CONCLUSIONS: Our data demonstrate that the low-glucose dialysis regimen is associated with reduced intra-peritoneal inflammatory and fibrotic response, and thus potentially result in better preservation of the structural and functional property of the peritoneum during long-term peritoneal dialysis.-
dc.languageengen_US
dc.publisherAmerican Society of Nephrology. The Journal's web site is located at http://www.jasn.org-
dc.relation.ispartofJournal of the American Society of Nephrologyen_US
dc.titleImpact of a low-glucose peritoneal dialysis regimen on inflammatory and fibrotic mediators in effluent dialysateen_US
dc.typeConference_Paperen_US
dc.identifier.emailYung, S: ssyyung@hku.hken_US
dc.identifier.emailNg, C: Chris_ng24@hotmail.comen_US
dc.identifier.emailYim, A: anndyim@hku.hken_US
dc.identifier.emailLui, SL: sllui@hkucc.hku.hken_US
dc.identifier.emailChan, DTM: dtmchan@hku.hken_US
dc.identifier.authorityYung, S=rp00455en_US
dc.identifier.authorityChan, DTM=rp00394en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros205062en_US
dc.identifier.volume2011-
dc.identifier.issuemeeting abstracts-
dc.identifier.spage735A-
dc.identifier.epage735A-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats