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Article: Not only dopamine D2 receptors involved in Peony-Glycyrrhiza Decoction, an herbal preparation against antipsychotic-associated hyperprolactinemia

TitleNot only dopamine D2 receptors involved in Peony-Glycyrrhiza Decoction, an herbal preparation against antipsychotic-associated hyperprolactinemia
Authors
KeywordsAntipsychotics
D2 receptors
Dopamine
Herbal medicine
Hyperprolactinemia
Peony-Glycyrrhiza Decoction (PGD)
Issue Date2012
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pnpbp
Citation
Progress In Neuro-Psychopharmacology And Biological Psychiatry, 2012, v. 39 n. 2, p. 332-338 How to Cite?
AbstractClinical studies have demonstrated the effectiveness of an herbal preparation called Peony-Glycyrrhiza Decoction (PGD) in alleviating antipsychotic-induced hyperprolactinemia (hyperPRL). In the present study, we further examined the pharmacological action of PGD on prolactin (PRL) secretion using in vitro and in vivo models, with specific attention to the role of dopaminergic mediators and other sex hormones. Treatment with PGD at 1-5mg/ml significantly suppressed PRL secretion and synthesis in MMQ cells, a model of hyperPRL derived from pituitary adenoma cells. The suppressive effects were completely abolished by pretreatment with 10μM haloperidol, a dopamine D2 receptor antagonist. Consistent with a D2-action, PGD did not affect PRL in rat pituitary lactotropic tumor-derived GH3 cells that lack the D2 receptor expression but significantly increased the expression of D2 receptors and dopamine transporters (DAT) in PC12 cells. In a rat model of hyperPRL, produced by repeated injection of the dopamine blocker metoclopramide (MCP), chronic PGD (2.5-10g/kg daily) significantly reduced elevated serum PRL. The reduction in magnitude was similar to that elicited by bromocriptine (BMT), a dopamine D2 receptor agonist currently used for treatment of hyperPRL. Neither PGD nor BMT altered serum estradiol, but PGD reversed decreased serum progesterone to control level, whereas BMT did not. These results indicate that the anti-hyperPRL effects of PGD are associated not only with D2 receptor and DAT modulation, but also with a normalization of other sex hormone dysfunction. This experimental evidence supports clinical use of PGD as an effective treatment of antipsychotic-induced hyperPRL. © 2012 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/159823
ISSN
2014 Impact Factor: 3.689
2014 SCImago Journal Rankings: 1.475
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Den_HK
dc.contributor.authorWong, HKen_HK
dc.contributor.authorZhang, Len_HK
dc.contributor.authorMcAlonan, GMen_HK
dc.contributor.authorWang, XMen_HK
dc.contributor.authorSze, SCWen_HK
dc.contributor.authorFeng, YBen_HK
dc.contributor.authorZhang, ZJen_HK
dc.date.accessioned2012-08-16T05:57:39Z-
dc.date.available2012-08-16T05:57:39Z-
dc.date.issued2012en_HK
dc.identifier.citationProgress In Neuro-Psychopharmacology And Biological Psychiatry, 2012, v. 39 n. 2, p. 332-338en_HK
dc.identifier.issn0278-5846en_HK
dc.identifier.urihttp://hdl.handle.net/10722/159823-
dc.description.abstractClinical studies have demonstrated the effectiveness of an herbal preparation called Peony-Glycyrrhiza Decoction (PGD) in alleviating antipsychotic-induced hyperprolactinemia (hyperPRL). In the present study, we further examined the pharmacological action of PGD on prolactin (PRL) secretion using in vitro and in vivo models, with specific attention to the role of dopaminergic mediators and other sex hormones. Treatment with PGD at 1-5mg/ml significantly suppressed PRL secretion and synthesis in MMQ cells, a model of hyperPRL derived from pituitary adenoma cells. The suppressive effects were completely abolished by pretreatment with 10μM haloperidol, a dopamine D2 receptor antagonist. Consistent with a D2-action, PGD did not affect PRL in rat pituitary lactotropic tumor-derived GH3 cells that lack the D2 receptor expression but significantly increased the expression of D2 receptors and dopamine transporters (DAT) in PC12 cells. In a rat model of hyperPRL, produced by repeated injection of the dopamine blocker metoclopramide (MCP), chronic PGD (2.5-10g/kg daily) significantly reduced elevated serum PRL. The reduction in magnitude was similar to that elicited by bromocriptine (BMT), a dopamine D2 receptor agonist currently used for treatment of hyperPRL. Neither PGD nor BMT altered serum estradiol, but PGD reversed decreased serum progesterone to control level, whereas BMT did not. These results indicate that the anti-hyperPRL effects of PGD are associated not only with D2 receptor and DAT modulation, but also with a normalization of other sex hormone dysfunction. This experimental evidence supports clinical use of PGD as an effective treatment of antipsychotic-induced hyperPRL. © 2012 Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pnpbpen_HK
dc.relation.ispartofProgress in Neuro-Psychopharmacology and Biological Psychiatryen_HK
dc.subjectAntipsychoticsen_HK
dc.subjectD2 receptorsen_HK
dc.subjectDopamineen_HK
dc.subjectHerbal medicineen_HK
dc.subjectHyperprolactinemiaen_HK
dc.subjectPeony-Glycyrrhiza Decoction (PGD)en_HK
dc.titleNot only dopamine D2 receptors involved in Peony-Glycyrrhiza Decoction, an herbal preparation against antipsychotic-associated hyperprolactinemiaen_HK
dc.typeArticleen_HK
dc.identifier.emailMcAlonan, GM: mcalonan@hkucc.hku.hken_HK
dc.identifier.emailSze, SCW: stephens@hku.hken_HK
dc.identifier.emailFeng, YB: yfeng@hku.hken_HK
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hken_HK
dc.identifier.authorityMcAlonan, GM=rp00475en_HK
dc.identifier.authoritySze, SCW=rp00514en_HK
dc.identifier.authorityFeng, YB=rp00466en_HK
dc.identifier.authorityZhang, ZJ=rp01297en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.pnpbp.2012.07.005en_HK
dc.identifier.pmid22796279-
dc.identifier.scopuseid_2-s2.0-84867024470en_HK
dc.identifier.hkuros205007en_US
dc.identifier.hkuros208633-
dc.identifier.hkuros217179-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84867024470&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue2en_HK
dc.identifier.spage332en_HK
dc.identifier.epage338en_HK
dc.identifier.isiWOS:000310943500017-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWang, D=50562342400en_HK
dc.identifier.scopusauthoridWong, HK=36920239700en_HK
dc.identifier.scopusauthoridZhang, L=37100561300en_HK
dc.identifier.scopusauthoridMcAlonan, GM=6603123011en_HK
dc.identifier.scopusauthoridWang, XM=55317995100en_HK
dc.identifier.scopusauthoridSze, SCW=23482617000en_HK
dc.identifier.scopusauthoridFeng, YB=24467969600en_HK
dc.identifier.scopusauthoridZhang, ZJ=8061473900en_HK
dc.identifier.citeulike11583355-

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