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Article: Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity

TitleActivation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity
Authors
Issue Date2012
PublisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/
Citation
Journal of Biological Chemistry, 2012, v. 287 n. 17, p. 13561-13571 How to Cite?
Abstract
Natural killer T (NKT) cells are important therapeutic targets in various disease models and are under clinical trials for cancer patients. However, their function in obesity and type 2 diabetes remains unclear. Our data show that adipose tissues of both mice and humans contain a population of type 1 NKT cells, whose abundance decreases with increased adiposity and insulin resistance. Although loss-of-function of NKT cells had no effect on glucose tolerance in animals with prolonged high fat diet feeding, activation of NKT cells by lipid agonist alpha-galactosylceramide enhances alternative macrophage polarization in adipose tissue and improves glucose homeostasis in animals at different stages of obesity. Furthermore, the effect of NKT cells is largely mediated by the IL-4/STAT6 signaling axis in obese adipose tissue. Thus, our data identify a novel therapeutic target for the treatment of obesity-associated inflammation and type 2 diabetes.
Persistent Identifierhttp://hdl.handle.net/10722/159707
ISSN
2013 Impact Factor: 4.600
PubMed Central ID
ISI Accession Number ID

 

Author Affiliations
  1. Harvard School of Public Health
  2. Cornell University
  3. The University of Hong Kong
  4. Wageningen University and Research Centre
  5. National Institute on Alcohol Abuse and Alcoholism
DC FieldValueLanguage
dc.contributor.authorJi, Yen_US
dc.contributor.authorSun, Sen_US
dc.contributor.authorXu, Aen_US
dc.contributor.authorBhargava, Pen_US
dc.contributor.authorYang, Len_US
dc.contributor.authorLam, KSLen_US
dc.contributor.authorGao, Ben_US
dc.contributor.authorLee, CHen_US
dc.contributor.authorKersten, Sen_US
dc.contributor.authorQi, Len_US
dc.date.accessioned2012-08-16T05:54:13Z-
dc.date.available2012-08-16T05:54:13Z-
dc.date.issued2012en_US
dc.identifier.citationJournal of Biological Chemistry, 2012, v. 287 n. 17, p. 13561-13571en_US
dc.identifier.issn0021-9258en_US
dc.identifier.urihttp://hdl.handle.net/10722/159707-
dc.description.abstractNatural killer T (NKT) cells are important therapeutic targets in various disease models and are under clinical trials for cancer patients. However, their function in obesity and type 2 diabetes remains unclear. Our data show that adipose tissues of both mice and humans contain a population of type 1 NKT cells, whose abundance decreases with increased adiposity and insulin resistance. Although loss-of-function of NKT cells had no effect on glucose tolerance in animals with prolonged high fat diet feeding, activation of NKT cells by lipid agonist alpha-galactosylceramide enhances alternative macrophage polarization in adipose tissue and improves glucose homeostasis in animals at different stages of obesity. Furthermore, the effect of NKT cells is largely mediated by the IL-4/STAT6 signaling axis in obese adipose tissue. Thus, our data identify a novel therapeutic target for the treatment of obesity-associated inflammation and type 2 diabetes.-
dc.languageengen_US
dc.publisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/-
dc.relation.ispartofJournal of Biological Chemistryen_US
dc.rightsJournal of Biological Chemistry. Copyright © American Society for Biochemistry and Molecular Biology, Inc.-
dc.rightsThis research was originally published in [Journal of Biological Chemistry]. Yi, Y., Sun, S. & Xu, A. Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity. Journal of Biological Chemistry. 2012. Vol 287:pp 13561-pp 13571. © the American Society for Biochemistry and Molecular Biology-
dc.subject.meshAdipose Tissue - cytology - metabolism-
dc.subject.meshGlucose - metabolism-
dc.subject.meshGlucose Tolerance Test-
dc.subject.meshKiller Cells, Natural - metabolism-
dc.subject.meshMacrophages - cytology-
dc.titleActivation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesityen_US
dc.typeArticleen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1083-351X (Electronic)0021-9258 (Linkin&volume=287&issue=17&spage=13561&epage=71&date=2012&atitle=Activation+of+natural+killer+T+cells+promotes+M2+Macrophage+polarization+in+adipose+tissue+and+improves+systemic+glucose+tolerance+via+interleukin-4+(IL-4)/STAT6+protein+signaling+axis+in+obesityen_US
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_US
dc.identifier.emailLam, KSL: ksllam@hku.hken_US
dc.identifier.emailQi, L: lq35@cornell.edu-
dc.identifier.authorityXu, A=rp00485en_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1074/jbc.M112.350066-
dc.identifier.pmid22396530-
dc.identifier.pmcidPMC3340139-
dc.identifier.scopuseid_2-s2.0-84859997837-
dc.identifier.hkuros205686en_US
dc.identifier.volume287en_US
dc.identifier.issue17en_US
dc.identifier.spage13561en_US
dc.identifier.epage13571en_US
dc.identifier.isiWOS:000303996300013-
dc.publisher.placeUnited States-

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