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Article: The role of hyaluronan and CD44 in the pathogenesis of lupus nephritis

TitleThe role of hyaluronan and CD44 in the pathogenesis of lupus nephritis
Authors
KeywordsMedical sciences
Abstracting, bibliographies, statistics medical sciences
Allergology and immunology medical sciences
Rheumatology biology
Biochemistry abstracting and indexing services
Issue Date2012
PublisherSUBIS.
Citation
Autoimmune Diseases, 2012, v. 2012, article no. 207190 How to Cite?
AbstractSystemic lupus erythematosus (SLE) is a prototype autoimmune disease that affects multiorgan systems. Lupus nephritis is one of the most severe manifestations of SLE whereby immune-mediated inflammation can lead to permanent damage within the glomerular, tubulo-interstitial, and vascular compartments of the kidney, resulting in acute or chronic renal failure. The mechanisms that regulate host inflammatory responses and tissue injury are incompletely understood. Accumulating evidence suggests that hyaluronan and its interaction with its cell surface receptor CD44 plays an important role in mediating pathogenic mechanisms in SLE. This paper discusses the putative mechanisms through which hyaluronan and CD44 contribute to the pathogenesis of SLE, with particular emphasis on lupus nephritis.
DescriptionReview article
Persistent Identifierhttp://hdl.handle.net/10722/159691
ISSN
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorYung, Sen_US
dc.contributor.authorChan, TMen_US
dc.date.accessioned2012-08-16T05:54:05Z-
dc.date.available2012-08-16T05:54:05Z-
dc.date.issued2012en_US
dc.identifier.citationAutoimmune Diseases, 2012, v. 2012, article no. 207190en_US
dc.identifier.issn0142-8365-
dc.identifier.urihttp://hdl.handle.net/10722/159691-
dc.descriptionReview article-
dc.description.abstractSystemic lupus erythematosus (SLE) is a prototype autoimmune disease that affects multiorgan systems. Lupus nephritis is one of the most severe manifestations of SLE whereby immune-mediated inflammation can lead to permanent damage within the glomerular, tubulo-interstitial, and vascular compartments of the kidney, resulting in acute or chronic renal failure. The mechanisms that regulate host inflammatory responses and tissue injury are incompletely understood. Accumulating evidence suggests that hyaluronan and its interaction with its cell surface receptor CD44 plays an important role in mediating pathogenic mechanisms in SLE. This paper discusses the putative mechanisms through which hyaluronan and CD44 contribute to the pathogenesis of SLE, with particular emphasis on lupus nephritis.-
dc.languageengen_US
dc.publisherSUBIS.-
dc.relation.ispartofAutoimmune Diseasesen_US
dc.subjectMedical sciences-
dc.subjectAbstracting, bibliographies, statistics medical sciences-
dc.subjectAllergology and immunology medical sciences-
dc.subjectRheumatology biology-
dc.subjectBiochemistry abstracting and indexing services-
dc.titleThe role of hyaluronan and CD44 in the pathogenesis of lupus nephritisen_US
dc.typeArticleen_US
dc.identifier.emailYung, S: ssyyung@hku.hken_US
dc.identifier.emailChan, TM: dtmchan@hku.hken_US
dc.identifier.authorityYung, S=rp00455en_US
dc.identifier.authorityChan, TM=rp00394en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1155/2012/207190-
dc.identifier.pmid22900150-
dc.identifier.pmcidPMC3415140-
dc.identifier.hkuros204928en_US
dc.identifier.volume2012-
dc.publisher.placeUnited Kingdom-

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