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- Publisher Website: 10.1155/2012/207190
- Scopus: eid_2-s2.0-84874888194
- PMID: 22900150
- WOS: WOS:000219156700007
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Article: The role of hyaluronan and CD44 in the pathogenesis of lupus nephritis
Title | The role of hyaluronan and CD44 in the pathogenesis of lupus nephritis |
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Authors | |
Keywords | Medical sciences Abstracting, bibliographies, statistics medical sciences Allergology and immunology medical sciences Rheumatology biology Biochemistry abstracting and indexing services |
Issue Date | 2012 |
Publisher | SUBIS. |
Citation | Autoimmune Diseases, 2012, v. 2012, article no. 207190 How to Cite? |
Abstract | Systemic lupus erythematosus (SLE) is a prototype autoimmune disease that affects multiorgan systems. Lupus nephritis is one of the most severe manifestations of SLE whereby immune-mediated inflammation can lead to permanent damage within the glomerular, tubulo-interstitial, and vascular compartments of the kidney, resulting in acute or chronic renal failure. The mechanisms that regulate host inflammatory responses and tissue injury are incompletely understood. Accumulating evidence suggests that hyaluronan and its interaction with its cell surface receptor CD44 plays an important role in mediating pathogenic mechanisms in SLE. This paper discusses the putative mechanisms through which hyaluronan and CD44 contribute to the pathogenesis of SLE, with particular emphasis on lupus nephritis. |
Description | Review article |
Persistent Identifier | http://hdl.handle.net/10722/159691 |
ISSN | |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yung, S | en_US |
dc.contributor.author | Chan, TM | en_US |
dc.date.accessioned | 2012-08-16T05:54:05Z | - |
dc.date.available | 2012-08-16T05:54:05Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Autoimmune Diseases, 2012, v. 2012, article no. 207190 | en_US |
dc.identifier.issn | 0142-8365 | - |
dc.identifier.uri | http://hdl.handle.net/10722/159691 | - |
dc.description | Review article | - |
dc.description.abstract | Systemic lupus erythematosus (SLE) is a prototype autoimmune disease that affects multiorgan systems. Lupus nephritis is one of the most severe manifestations of SLE whereby immune-mediated inflammation can lead to permanent damage within the glomerular, tubulo-interstitial, and vascular compartments of the kidney, resulting in acute or chronic renal failure. The mechanisms that regulate host inflammatory responses and tissue injury are incompletely understood. Accumulating evidence suggests that hyaluronan and its interaction with its cell surface receptor CD44 plays an important role in mediating pathogenic mechanisms in SLE. This paper discusses the putative mechanisms through which hyaluronan and CD44 contribute to the pathogenesis of SLE, with particular emphasis on lupus nephritis. | - |
dc.language | eng | en_US |
dc.publisher | SUBIS. | - |
dc.relation.ispartof | Autoimmune Diseases | en_US |
dc.subject | Medical sciences | - |
dc.subject | Abstracting, bibliographies, statistics medical sciences | - |
dc.subject | Allergology and immunology medical sciences | - |
dc.subject | Rheumatology biology | - |
dc.subject | Biochemistry abstracting and indexing services | - |
dc.title | The role of hyaluronan and CD44 in the pathogenesis of lupus nephritis | en_US |
dc.type | Article | en_US |
dc.identifier.email | Yung, S: ssyyung@hku.hk | en_US |
dc.identifier.email | Chan, TM: dtmchan@hku.hk | en_US |
dc.identifier.authority | Yung, S=rp00455 | en_US |
dc.identifier.authority | Chan, TM=rp00394 | en_US |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1155/2012/207190 | - |
dc.identifier.pmid | 22900150 | - |
dc.identifier.pmcid | PMC3415140 | - |
dc.identifier.scopus | eid_2-s2.0-84874888194 | - |
dc.identifier.hkuros | 204928 | en_US |
dc.identifier.volume | 2012 | - |
dc.identifier.isi | WOS:000219156700007 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0142-8365 | - |