File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Treatment effectiveness of two Chinese herbal medicine formulae in upper respiratory tract infections: a randomized double-blind placebo-controlled trial
  • Basic View
  • Metadata View
  • XML View
TitleTreatment effectiveness of two Chinese herbal medicine formulae in upper respiratory tract infections: a randomized double-blind placebo-controlled trial
 
AuthorsWong, W1
Lam, CLK1
Fong, DYT1
 
KeywordsChinese medicine
Family medicine
Infectious diseases
Multidisciplinary care
Randomized controlled trial
 
Issue Date2012
 
PublisherOxford University Press. The Journal's web site is located at http://fampra.oxfordjournals.org/
 
CitationFamily Practice, 2012, v. 29 n. 6, p. 643-652 [How to Cite?]
DOI: http://dx.doi.org/10.1093/fampra/cms027
 
AbstractAim and objectives To study the effect of two Chinese herbal medicines (CHMs) formulae in treating acute upper respiratory tract infections (URTIs), diagnosed by Traditional Chinese medicine (TCM), compared to placebo. Design Two randomized, double-blind placebo-controlled trials nested in a study of 327 patients who were diagnosed with URTIs in Hong Kong. Subjects were classified into one of two TCM syndrome groups by a Chinese medicine practitioner and randomized to receive the corresponding CHM formulae or placebo up to maximum of 10 days. The proportions of patients who had resolution of illness on Days 4 and 7 were the primary outcomes. The duration of symptom resolution, health-related quality of life scores measured by the SF-36 and ChQOL, and adverse effects were secondary outcomes. Results There was no statistically significant difference between the treatment and placebo in resolution rates at Day 4 or 7. The mean time of resolution of symptoms was Day 10, for either wind-cold or wind-heat syndrome. Both patients in treatment and placebo had significantly improved in health-related quality of life with time, but patients in wind-cold group had significantly more improvement in the SF-36 general health score (P = 0.01) than placebo. Conclusions Two CHM formulae commonly used for URTIs were not found to be more effective than placebo in either cure or reduction of symptoms of URTIs. However, Jing Fan Bai Du san might be able to improve general health more than placebo for patients with wind-cold syndrome. Both formulae were not associated with any more side effects.
 
ISSN0263-2136
2013 Impact Factor: 1.842
 
DOIhttp://dx.doi.org/10.1093/fampra/cms027
 
ISI Accession Number IDWOS:000311637500004
 
DC FieldValue
dc.contributor.authorWong, W
 
dc.contributor.authorLam, CLK
 
dc.contributor.authorFong, DYT
 
dc.date.accessioned2012-08-16T05:53:05Z
 
dc.date.available2012-08-16T05:53:05Z
 
dc.date.issued2012
 
dc.description.abstractAim and objectives To study the effect of two Chinese herbal medicines (CHMs) formulae in treating acute upper respiratory tract infections (URTIs), diagnosed by Traditional Chinese medicine (TCM), compared to placebo. Design Two randomized, double-blind placebo-controlled trials nested in a study of 327 patients who were diagnosed with URTIs in Hong Kong. Subjects were classified into one of two TCM syndrome groups by a Chinese medicine practitioner and randomized to receive the corresponding CHM formulae or placebo up to maximum of 10 days. The proportions of patients who had resolution of illness on Days 4 and 7 were the primary outcomes. The duration of symptom resolution, health-related quality of life scores measured by the SF-36 and ChQOL, and adverse effects were secondary outcomes. Results There was no statistically significant difference between the treatment and placebo in resolution rates at Day 4 or 7. The mean time of resolution of symptoms was Day 10, for either wind-cold or wind-heat syndrome. Both patients in treatment and placebo had significantly improved in health-related quality of life with time, but patients in wind-cold group had significantly more improvement in the SF-36 general health score (P = 0.01) than placebo. Conclusions Two CHM formulae commonly used for URTIs were not found to be more effective than placebo in either cure or reduction of symptoms of URTIs. However, Jing Fan Bai Du san might be able to improve general health more than placebo for patients with wind-cold syndrome. Both formulae were not associated with any more side effects.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationFamily Practice, 2012, v. 29 n. 6, p. 643-652 [How to Cite?]
DOI: http://dx.doi.org/10.1093/fampra/cms027
 
dc.identifier.doihttp://dx.doi.org/10.1093/fampra/cms027
 
dc.identifier.epage652
 
dc.identifier.hkuros203629
 
dc.identifier.isiWOS:000311637500004
 
dc.identifier.issn0263-2136
2013 Impact Factor: 1.842
 
dc.identifier.issue6
 
dc.identifier.pmid22490614
 
dc.identifier.scopuseid_2-s2.0-84869998348
 
dc.identifier.spage643
 
dc.identifier.urihttp://hdl.handle.net/10722/159597
 
dc.identifier.volume29
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://fampra.oxfordjournals.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofFamily Practice
 
dc.subjectChinese medicine
 
dc.subjectFamily medicine
 
dc.subjectInfectious diseases
 
dc.subjectMultidisciplinary care
 
dc.subjectRandomized controlled trial
 
dc.titleTreatment effectiveness of two Chinese herbal medicine formulae in upper respiratory tract infections: a randomized double-blind placebo-controlled trial
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Wong, W</contributor.author>
<contributor.author>Lam, CLK</contributor.author>
<contributor.author>Fong, DYT</contributor.author>
<date.accessioned>2012-08-16T05:53:05Z</date.accessioned>
<date.available>2012-08-16T05:53:05Z</date.available>
<date.issued>2012</date.issued>
<identifier.citation>Family Practice, 2012, v. 29 n. 6, p. 643-652</identifier.citation>
<identifier.issn>0263-2136</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/159597</identifier.uri>
<description.abstract>Aim and objectives To study the effect of two Chinese herbal medicines (CHMs) formulae in treating acute upper respiratory tract infections (URTIs), diagnosed by Traditional Chinese medicine (TCM), compared to placebo. Design Two randomized, double-blind placebo-controlled trials nested in a study of 327 patients who were diagnosed with URTIs in Hong Kong. Subjects were classified into one of two TCM syndrome groups by a Chinese medicine practitioner and randomized to receive the corresponding CHM formulae or placebo up to maximum of 10 days. The proportions of patients who had resolution of illness on Days 4 and 7 were the primary outcomes. The duration of symptom resolution, health-related quality of life scores measured by the SF-36 and ChQOL, and adverse effects were secondary outcomes. Results There was no statistically significant difference between the treatment and placebo in resolution rates at Day 4 or 7. The mean time of resolution of symptoms was Day 10, for either wind-cold or wind-heat syndrome. Both patients in treatment and placebo had significantly improved in health-related quality of life with time, but patients in wind-cold group had significantly more improvement in the SF-36 general health score (P = 0.01) than placebo. Conclusions Two CHM formulae commonly used for URTIs were not found to be more effective than placebo in either cure or reduction of symptoms of URTIs. However, Jing Fan Bai Du san might be able to improve general health more than placebo for patients with wind-cold syndrome. Both formulae were not associated with any more side effects.</description.abstract>
<language>eng</language>
<publisher>Oxford University Press. The Journal&apos;s web site is located at http://fampra.oxfordjournals.org/</publisher>
<relation.ispartof>Family Practice</relation.ispartof>
<subject>Chinese medicine</subject>
<subject>Family medicine</subject>
<subject>Infectious diseases</subject>
<subject>Multidisciplinary care</subject>
<subject>Randomized controlled trial</subject>
<title>Treatment effectiveness of two Chinese herbal medicine formulae in upper respiratory tract infections: a randomized double-blind placebo-controlled trial</title>
<type>Article</type>
<description.nature>link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1093/fampra/cms027</identifier.doi>
<identifier.pmid>22490614</identifier.pmid>
<identifier.scopus>eid_2-s2.0-84869998348</identifier.scopus>
<identifier.hkuros>203629</identifier.hkuros>
<identifier.volume>29</identifier.volume>
<identifier.issue>6</identifier.issue>
<identifier.spage>643</identifier.spage>
<identifier.epage>652</identifier.epage>
<identifier.isi>WOS:000311637500004</identifier.isi>
<publisher.place>United Kingdom</publisher.place>
</item>
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine