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Article: Treatment effectiveness of two Chinese herbal medicine formulae in upper respiratory tract infections: a randomized double-blind placebo-controlled trial

TitleTreatment effectiveness of two Chinese herbal medicine formulae in upper respiratory tract infections: a randomized double-blind placebo-controlled trial
Authors
KeywordsChinese medicine
Family medicine
Infectious diseases
Multidisciplinary care
Randomized controlled trial
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://fampra.oxfordjournals.org/
Citation
Family Practice, 2012, v. 29 n. 6, p. 643-652 How to Cite?
Abstract
Aim and objectives To study the effect of two Chinese herbal medicines (CHMs) formulae in treating acute upper respiratory tract infections (URTIs), diagnosed by Traditional Chinese medicine (TCM), compared to placebo. Design Two randomized, double-blind placebo-controlled trials nested in a study of 327 patients who were diagnosed with URTIs in Hong Kong. Subjects were classified into one of two TCM syndrome groups by a Chinese medicine practitioner and randomized to receive the corresponding CHM formulae or placebo up to maximum of 10 days. The proportions of patients who had resolution of illness on Days 4 and 7 were the primary outcomes. The duration of symptom resolution, health-related quality of life scores measured by the SF-36 and ChQOL, and adverse effects were secondary outcomes. Results There was no statistically significant difference between the treatment and placebo in resolution rates at Day 4 or 7. The mean time of resolution of symptoms was Day 10, for either wind-cold or wind-heat syndrome. Both patients in treatment and placebo had significantly improved in health-related quality of life with time, but patients in wind-cold group had significantly more improvement in the SF-36 general health score (P = 0.01) than placebo. Conclusions Two CHM formulae commonly used for URTIs were not found to be more effective than placebo in either cure or reduction of symptoms of URTIs. However, Jing Fan Bai Du san might be able to improve general health more than placebo for patients with wind-cold syndrome. Both formulae were not associated with any more side effects.
Persistent Identifierhttp://hdl.handle.net/10722/159597
ISSN
2013 Impact Factor: 1.842
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, Wen_US
dc.contributor.authorLam, CLKen_US
dc.contributor.authorFong, DYTen_US
dc.date.accessioned2012-08-16T05:53:05Z-
dc.date.available2012-08-16T05:53:05Z-
dc.date.issued2012en_US
dc.identifier.citationFamily Practice, 2012, v. 29 n. 6, p. 643-652en_US
dc.identifier.issn0263-2136-
dc.identifier.urihttp://hdl.handle.net/10722/159597-
dc.description.abstractAim and objectives To study the effect of two Chinese herbal medicines (CHMs) formulae in treating acute upper respiratory tract infections (URTIs), diagnosed by Traditional Chinese medicine (TCM), compared to placebo. Design Two randomized, double-blind placebo-controlled trials nested in a study of 327 patients who were diagnosed with URTIs in Hong Kong. Subjects were classified into one of two TCM syndrome groups by a Chinese medicine practitioner and randomized to receive the corresponding CHM formulae or placebo up to maximum of 10 days. The proportions of patients who had resolution of illness on Days 4 and 7 were the primary outcomes. The duration of symptom resolution, health-related quality of life scores measured by the SF-36 and ChQOL, and adverse effects were secondary outcomes. Results There was no statistically significant difference between the treatment and placebo in resolution rates at Day 4 or 7. The mean time of resolution of symptoms was Day 10, for either wind-cold or wind-heat syndrome. Both patients in treatment and placebo had significantly improved in health-related quality of life with time, but patients in wind-cold group had significantly more improvement in the SF-36 general health score (P = 0.01) than placebo. Conclusions Two CHM formulae commonly used for URTIs were not found to be more effective than placebo in either cure or reduction of symptoms of URTIs. However, Jing Fan Bai Du san might be able to improve general health more than placebo for patients with wind-cold syndrome. Both formulae were not associated with any more side effects.-
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://fampra.oxfordjournals.org/-
dc.relation.ispartofFamily Practiceen_US
dc.subjectChinese medicine-
dc.subjectFamily medicine-
dc.subjectInfectious diseases-
dc.subjectMultidisciplinary care-
dc.subjectRandomized controlled trial-
dc.titleTreatment effectiveness of two Chinese herbal medicine formulae in upper respiratory tract infections: a randomized double-blind placebo-controlled trialen_US
dc.typeArticleen_US
dc.identifier.emailWong, W: wwong110@hku.hken_US
dc.identifier.emailLam, CLK: clklam@hku.hken_US
dc.identifier.emailFong, DYT: dytfong@hku.hken_US
dc.identifier.authorityLam, CLK=rp00350en_US
dc.identifier.authorityFong, DYT=rp00253en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/fampra/cms027-
dc.identifier.pmid22490614-
dc.identifier.scopuseid_2-s2.0-84869998348-
dc.identifier.hkuros203629en_US
dc.identifier.volume29-
dc.identifier.issue6-
dc.identifier.spage643-
dc.identifier.epage652-
dc.identifier.isiWOS:000311637500004-
dc.publisher.placeUnited Kingdom-

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