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Conference Paper: Liver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors

TitleLiver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors
Authors
KeywordsBiosensing platforms
Clinical diagnostics
Concentration ratio
Experimental data
Hepatic tumors
Issue Date2012
PublisherAmerican Institute of Physics. The Journal's web site is located at http://jap.aip.org/jap/staff.jsp
Citation
The 56th Conference on Magnetism and Magnetic Materials, Scottsdale, AZ., 30 October-3 November 2011. In Journal of Applied Physics, 2012, v. 111 n. 7, article no. 07E505 How to Cite?
Abstract
We have demonstrated the detection of alpha-fetoprotein (AFP) labeled with magnetic nanoparticles (MNPs) using MgO-based magnetic tunnel junction (MTJ) sensors. AFP is an important hepatic tumor biomarker and the detection of AFP has significant applications for clinical diagnostics and immunoassay for early-stage liver cancer indications. In this work, MgO-based MTJ sensors and 20-nm iron-oxide magnetic nanoparticles (MNPs) were used for detecting AFP antigens by a sandwich-assay configuration. The MTJ sensors with a sensing area of 4 × 2 μm 2 possess tunneling magnetoresistance (TMR) of 122 and sensitivity of 0.95/Oe at room temperature. The target AFP antigens of three concentrations were successfully detected, and the experimental data indicate that the resistance variations of the MTJ sensor increased with the AFP concentration ratios proportionally. These results demonstrate that MgO-based MTJ sensors together with MNPs are a promising biosensing platform for liver cancer immunoassay. © 2012 American Institute of Physics.
DescriptionSession DV - Sensors II (Poster Session): no. DV-07
Persistent Identifierhttp://hdl.handle.net/10722/158793
ISSN
2013 Impact Factor: 2.185
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong
RGC-GRFHKU 7049/11P
Funding Information:

The authors wish to thank X. Chen, Y. Zhou, and H. K. Y. Mak for their valuable assistance. This work was supported by the Seed Funding Program for Basic Research from the University of Hong Kong and the RGC-GRF grant (HKU 7049/11P).

References

 

DC FieldValueLanguage
dc.contributor.authorLei, Zen_HK
dc.contributor.authorLi, Len_HK
dc.contributor.authorLi, Gen_HK
dc.contributor.authorLeung, CWen_HK
dc.contributor.authorShi, Jen_HK
dc.contributor.authorWong, CMen_HK
dc.contributor.authorLo, KCen_HK
dc.contributor.authorChan, WKen_HK
dc.contributor.authorMak, CSKen_HK
dc.contributor.authorChan, SBen_HK
dc.contributor.authorChan, NMMen_HK
dc.contributor.authorLeung, CHen_HK
dc.contributor.authorLai, PTen_HK
dc.contributor.authorPong, PWTen_HK
dc.date.accessioned2012-08-08T09:01:22Z-
dc.date.available2012-08-08T09:01:22Z-
dc.date.issued2012en_HK
dc.identifier.citationThe 56th Conference on Magnetism and Magnetic Materials, Scottsdale, AZ., 30 October-3 November 2011. In Journal of Applied Physics, 2012, v. 111 n. 7, article no. 07E505en_US
dc.identifier.issn0021-8979en_HK
dc.identifier.urihttp://hdl.handle.net/10722/158793-
dc.descriptionSession DV - Sensors II (Poster Session): no. DV-07-
dc.descriptionThis journal issue is proceedings of the 56th 56th Conference on Magnetism and Magnetic Materials-
dc.description.abstractWe have demonstrated the detection of alpha-fetoprotein (AFP) labeled with magnetic nanoparticles (MNPs) using MgO-based magnetic tunnel junction (MTJ) sensors. AFP is an important hepatic tumor biomarker and the detection of AFP has significant applications for clinical diagnostics and immunoassay for early-stage liver cancer indications. In this work, MgO-based MTJ sensors and 20-nm iron-oxide magnetic nanoparticles (MNPs) were used for detecting AFP antigens by a sandwich-assay configuration. The MTJ sensors with a sensing area of 4 × 2 μm 2 possess tunneling magnetoresistance (TMR) of 122 and sensitivity of 0.95/Oe at room temperature. The target AFP antigens of three concentrations were successfully detected, and the experimental data indicate that the resistance variations of the MTJ sensor increased with the AFP concentration ratios proportionally. These results demonstrate that MgO-based MTJ sensors together with MNPs are a promising biosensing platform for liver cancer immunoassay. © 2012 American Institute of Physics.en_HK
dc.languageengen_US
dc.publisherAmerican Institute of Physics. The Journal's web site is located at http://jap.aip.org/jap/staff.jspen_HK
dc.relation.ispartofJournal of Applied Physicsen_HK
dc.rightsJournal of Applied Physics. Copyright © American Institute of Physics.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectBiosensing platforms-
dc.subjectClinical diagnostics-
dc.subjectConcentration ratio-
dc.subjectExperimental data-
dc.subjectHepatic tumors-
dc.titleLiver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensorsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLei, Z: leizq@hku.hken_HK
dc.identifier.emailLi, L: lilee77@HKUSUC.hku.hken_HK
dc.identifier.emailLi, G: guijun@HKUSUC.hku.hken_HK
dc.identifier.emailWong, CM: jcmwong@hkucc.hku.hk-
dc.identifier.emailLo, KC: h0415676@hku.hk-
dc.identifier.emailMak, CSK: cskm@hkucc.hku.hk-
dc.identifier.emailLeung, CH: chleung@eee.hku.hk-
dc.identifier.emailLai, PT: laip@eee.hku.hk-
dc.identifier.emailPong, PWT: ppong@eee.hku.hk-
dc.identifier.authorityWong, CM=rp00231en_HK
dc.identifier.authorityMak, CSK=rp00761en_HK
dc.identifier.authorityLeung, CH=rp00146en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1063/1.3676212en_HK
dc.identifier.scopuseid_2-s2.0-84861728395en_HK
dc.identifier.hkuros209742-
dc.identifier.hkuros225740-
dc.identifier.hkuros227868-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84861728395&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume111en_HK
dc.identifier.issue7, article no. 07E505en_HK
dc.identifier.eissn1089-7550-
dc.identifier.isiWOS:000303282401318-
dc.publisher.placeUnited Statesen_HK
dc.description.otherThe 56th Conference on Magnetism and Magnetic Materials, Scottsdale, AZ., 30 October-3 November 2011. In Journal of Applied Physics, 2012, v. 111 n. 7, article no. 07E505-
dc.identifier.scopusauthoridPong, PWT=55428301400en_HK
dc.identifier.scopusauthoridLai, PT=55329522200en_HK
dc.identifier.scopusauthoridLeung, CH=7402612415en_HK
dc.identifier.scopusauthoridChan, NMM=55236734500en_HK
dc.identifier.scopusauthoridChan, SB=55455880300en_HK
dc.identifier.scopusauthoridMak, CSK=8899597100en_HK
dc.identifier.scopusauthoridChan, WK=55152945600en_HK
dc.identifier.scopusauthoridLo, KC=55236413400en_HK
dc.identifier.scopusauthoridWong, CM=16314668400en_HK
dc.identifier.scopusauthoridShi, J=55236617700en_HK
dc.identifier.scopusauthoridLeung, CW=22958301300en_HK
dc.identifier.scopusauthoridLi, GJ=37002991600en_HK
dc.identifier.scopusauthoridLeung, CW=22958301300en_HK
dc.identifier.scopusauthoridLei, ZQ=37002974000en_HK

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