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Conference Paper: Liver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors
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TitleLiver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors
 
AuthorsLei, Z
Li, L1
Li, G
Leung, CW3
Shi, J2
Wong, CM1
Lo, KC1
Chan, WK1
Mak, CSK1
Chan, SB1
Chan, NMM4
Leung, CH1
Lai, PT1
Pong, PWT1
 
KeywordsBiosensing platforms
Clinical diagnostics
Concentration ratio
Experimental data
Hepatic tumors
 
Issue Date2012
 
PublisherAmerican Institute of Physics. The Journal's web site is located at http://jap.aip.org/jap/staff.jsp
 
CitationThe 56th Conference on Magnetism and Magnetic Materials, Scottsdale, AZ., 30 October-3 November 2011. In Journal of Applied Physics, 2012, v. 111 n. 7, article no. 07E505 [How to Cite?]
DOI: http://dx.doi.org/10.1063/1.3676212
 
AbstractWe have demonstrated the detection of alpha-fetoprotein (AFP) labeled with magnetic nanoparticles (MNPs) using MgO-based magnetic tunnel junction (MTJ) sensors. AFP is an important hepatic tumor biomarker and the detection of AFP has significant applications for clinical diagnostics and immunoassay for early-stage liver cancer indications. In this work, MgO-based MTJ sensors and 20-nm iron-oxide magnetic nanoparticles (MNPs) were used for detecting AFP antigens by a sandwich-assay configuration. The MTJ sensors with a sensing area of 4 × 2 μm 2 possess tunneling magnetoresistance (TMR) of 122 and sensitivity of 0.95/Oe at room temperature. The target AFP antigens of three concentrations were successfully detected, and the experimental data indicate that the resistance variations of the MTJ sensor increased with the AFP concentration ratios proportionally. These results demonstrate that MgO-based MTJ sensors together with MNPs are a promising biosensing platform for liver cancer immunoassay. © 2012 American Institute of Physics.
 
DescriptionSession DV - Sensors II (Poster Session): no. DV-07
This journal issue is proceedings of the 56th 56th Conference on Magnetism and Magnetic Materials
 
ISSN0021-8979
2013 Impact Factor: 2.185
 
DOIhttp://dx.doi.org/10.1063/1.3676212
 
ISI Accession Number IDWOS:000303282401318
Funding AgencyGrant Number
University of Hong Kong
RGC-GRFHKU 7049/11P
Funding Information:

The authors wish to thank X. Chen, Y. Zhou, and H. K. Y. Mak for their valuable assistance. This work was supported by the Seed Funding Program for Basic Research from the University of Hong Kong and the RGC-GRF grant (HKU 7049/11P).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLei, Z
 
dc.contributor.authorLi, L
 
dc.contributor.authorLi, G
 
dc.contributor.authorLeung, CW
 
dc.contributor.authorShi, J
 
dc.contributor.authorWong, CM
 
dc.contributor.authorLo, KC
 
dc.contributor.authorChan, WK
 
dc.contributor.authorMak, CSK
 
dc.contributor.authorChan, SB
 
dc.contributor.authorChan, NMM
 
dc.contributor.authorLeung, CH
 
dc.contributor.authorLai, PT
 
dc.contributor.authorPong, PWT
 
dc.date.accessioned2012-08-08T09:01:22Z
 
dc.date.available2012-08-08T09:01:22Z
 
dc.date.issued2012
 
dc.description.abstractWe have demonstrated the detection of alpha-fetoprotein (AFP) labeled with magnetic nanoparticles (MNPs) using MgO-based magnetic tunnel junction (MTJ) sensors. AFP is an important hepatic tumor biomarker and the detection of AFP has significant applications for clinical diagnostics and immunoassay for early-stage liver cancer indications. In this work, MgO-based MTJ sensors and 20-nm iron-oxide magnetic nanoparticles (MNPs) were used for detecting AFP antigens by a sandwich-assay configuration. The MTJ sensors with a sensing area of 4 × 2 μm 2 possess tunneling magnetoresistance (TMR) of 122 and sensitivity of 0.95/Oe at room temperature. The target AFP antigens of three concentrations were successfully detected, and the experimental data indicate that the resistance variations of the MTJ sensor increased with the AFP concentration ratios proportionally. These results demonstrate that MgO-based MTJ sensors together with MNPs are a promising biosensing platform for liver cancer immunoassay. © 2012 American Institute of Physics.
 
dc.description.naturepublished_or_final_version
 
dc.descriptionSession DV - Sensors II (Poster Session): no. DV-07
 
dc.descriptionThis journal issue is proceedings of the 56th 56th Conference on Magnetism and Magnetic Materials
 
dc.description.otherThe 56th Conference on Magnetism and Magnetic Materials, Scottsdale, AZ., 30 October-3 November 2011. In Journal of Applied Physics, 2012, v. 111 n. 7, article no. 07E505
 
dc.identifier.citationThe 56th Conference on Magnetism and Magnetic Materials, Scottsdale, AZ., 30 October-3 November 2011. In Journal of Applied Physics, 2012, v. 111 n. 7, article no. 07E505 [How to Cite?]
DOI: http://dx.doi.org/10.1063/1.3676212
 
dc.identifier.doihttp://dx.doi.org/10.1063/1.3676212
 
dc.identifier.eissn1089-7550
 
dc.identifier.hkuros209742
 
dc.identifier.hkuros225740
 
dc.identifier.hkuros227868
 
dc.identifier.isiWOS:000303282401318
Funding AgencyGrant Number
University of Hong Kong
RGC-GRFHKU 7049/11P
Funding Information:

The authors wish to thank X. Chen, Y. Zhou, and H. K. Y. Mak for their valuable assistance. This work was supported by the Seed Funding Program for Basic Research from the University of Hong Kong and the RGC-GRF grant (HKU 7049/11P).

 
dc.identifier.issn0021-8979
2013 Impact Factor: 2.185
 
dc.identifier.issue7, article no. 07E505
 
dc.identifier.scopuseid_2-s2.0-84861728395
 
dc.identifier.urihttp://hdl.handle.net/10722/158793
 
dc.identifier.volume111
 
dc.languageeng
 
dc.publisherAmerican Institute of Physics. The Journal's web site is located at http://jap.aip.org/jap/staff.jsp
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Applied Physics
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Applied Physics. Copyright © American Institute of Physics.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectBiosensing platforms
 
dc.subjectClinical diagnostics
 
dc.subjectConcentration ratio
 
dc.subjectExperimental data
 
dc.subjectHepatic tumors
 
dc.titleLiver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors
 
dc.typeConference_Paper
 
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<description.abstract>We have demonstrated the detection of alpha-fetoprotein (AFP) labeled with magnetic nanoparticles (MNPs) using MgO-based magnetic tunnel junction (MTJ) sensors. AFP is an important hepatic tumor biomarker and the detection of AFP has significant applications for clinical diagnostics and immunoassay for early-stage liver cancer indications. In this work, MgO-based MTJ sensors and 20-nm iron-oxide magnetic nanoparticles (MNPs) were used for detecting AFP antigens by a sandwich-assay configuration. The MTJ sensors with a sensing area of 4 &#215; 2 &#956;m 2 possess tunneling magnetoresistance (TMR) of 122 and sensitivity of 0.95/Oe at room temperature. The target AFP antigens of three concentrations were successfully detected, and the experimental data indicate that the resistance variations of the MTJ sensor increased with the AFP concentration ratios proportionally. These results demonstrate that MgO-based MTJ sensors together with MNPs are a promising biosensing platform for liver cancer immunoassay. &#169; 2012 American Institute of Physics.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. Hong Kong Baptist University
  3. Hong Kong Polytechnic University
  4. University of Cambridge