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Book Chapter: Genomics of hepatocellular carcinoma

TitleGenomics of hepatocellular carcinoma
Authors
KeywordsLiver -- Cancer.
Issue Date2012
PublisherSpringer
Citation
Genomics of hepatocellular carcinoma. In Gu, J (Ed.), Primary liver cancer : challenges and perspectives, p. 45-78. Heidelberg: Springer, 2012 How to Cite?
Hepatocarcinogenesis is a multistep process developing from a normal liver through chronic hepatitis and cirrhosis to HCC. The pathogenesis of HCC is poorly understood at present. There is insufficient understanding to propose a robust general model of hepatic carcinogenesis, partly because the pathogenic host and environmental factors show significant regional variation, making such generalization difficult. However, with advances in molecular technology, there is a growing understanding of the molecular mechanisms in the development of HCC. In hepatocarcinogenesis, there is a strong link to increases in allelic losses, chromosomal changes, gene mutations, epigenetic alterations and alterations in molecular cellular pathways. In this chapter, special focus is placed on the multistep process of hepatocarcinogenesis, genetics, epigenetics and regulation of major signaling pathways involved in hepatocarcinogenesis. A detailed understanding of the molecular pathogenesis involved in the progression of HCC can improve our prevention and diagnostic tools for HCC and may help identify novel molecular targets for new therapies. How to Cite?
Persistent Identifierhttp://hdl.handle.net/10722/153398
ISSN

 

DC FieldValueLanguage
dc.contributor.authorWong, CMen_US
dc.contributor.authorNg, IOLen_US
dc.date.accessioned2012-07-16T10:12:38Z-
dc.date.available2012-07-16T10:12:38Z-
dc.date.issued2012en_US
dc.identifier.citationGenomics of hepatocellular carcinoma. In Gu, J (Ed.), Primary liver cancer : challenges and perspectives, p. 45-78. Heidelberg: Springer, 2012-
dc.identifier.citationHepatocarcinogenesis is a multistep process developing from a normal liver through chronic hepatitis and cirrhosis to HCC. The pathogenesis of HCC is poorly understood at present. There is insufficient understanding to propose a robust general model of hepatic carcinogenesis, partly because the pathogenic host and environmental factors show significant regional variation, making such generalization difficult. However, with advances in molecular technology, there is a growing understanding of the molecular mechanisms in the development of HCC. In hepatocarcinogenesis, there is a strong link to increases in allelic losses, chromosomal changes, gene mutations, epigenetic alterations and alterations in molecular cellular pathways. In this chapter, special focus is placed on the multistep process of hepatocarcinogenesis, genetics, epigenetics and regulation of major signaling pathways involved in hepatocarcinogenesis. A detailed understanding of the molecular pathogenesis involved in the progression of HCC can improve our prevention and diagnostic tools for HCC and may help identify novel molecular targets for new therapies.-
dc.identifier.issn9783642287015en_US
dc.identifier.urihttp://hdl.handle.net/10722/153398-
dc.languageengen_US
dc.publisherSpringeren_US
dc.relation.ispartofPrimary liver cancer : challenges and perspectives-
dc.subjectLiver -- Cancer.-
dc.titleGenomics of hepatocellular carcinomaen_US
dc.typeBook_Chapteren_US
dc.identifier.emailWong, CM: jackwong@pathology.hku.hken_US
dc.identifier.emailNg, IOL: iolng@hku.hken_US
dc.identifier.authorityWong, CM=rp00231en_US
dc.identifier.authorityNg, IOL=rp00335en_US
dc.identifier.doi10.1007/978-3-642-28702-2_3-
dc.identifier.hkuros201253en_US
dc.identifier.spage45en_US
dc.identifier.epage78en_US
dc.publisher.placeHeidelberg-
dc.customcontrol.immutableyiu 130903-

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