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Conference Paper: An essential role for β1 integrin mediated cell-matrix interactions in the development and maintenance of the nucleus pulposus

TitleAn essential role for β1 integrin mediated cell-matrix interactions in the development and maintenance of the nucleus pulposus
Authors
Issue Date2012
PublisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.com/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=1351&category_id=90&option=com_virtuemart&Itemid=53
Citation
The World Forum for Spine Research (WFSR 2012): The Intervertebral Disc - from Degeneration to Pain, Helsinki, Finland, 18-21 June 2012. In Global Spine Journal, 2012, v. 2 n. S1, no. P44 How to Cite?
AbstractINTRODUCTION: In humans, the almost total disappearance of notochordal cells in the nucleus pulposus (NP) correlates with early degenerative changes in the intervertebral disk which include changes in the extracellular matrix (ECM). Recent cell lineage studies in mice suggest cells within the NP are derived from the early embryonic notochord. Since notochordal cells are surrounded by a rich ECM, the functions of the notochord and the NP are likely mediated via cell-matrix interactions. Integrin heterodimers are transmembrane proteins and are the major adhesion receptors that mediate cell-matrix interactions. They connect the ECM to the intracellular cytoskeleton and transduce bidirectional signals between the extracellular matrix and intracellular compartments. At least 24 integrin heterodimers have been identified, and among them receptors cont...
Persistent Identifierhttp://hdl.handle.net/10722/153036
ISSN
2015 SCImago Journal Rankings: 0.108

 

DC FieldValueLanguage
dc.contributor.authorGuo, Sen_US
dc.contributor.authorAu, SYKen_US
dc.contributor.authorWynn, Sen_US
dc.contributor.authorChan, Den_US
dc.contributor.authorAszodi, Aen_US
dc.contributor.authorFassler, Ren_US
dc.contributor.authorCheah, KSEen_US
dc.date.accessioned2012-07-16T09:55:01Z-
dc.date.available2012-07-16T09:55:01Z-
dc.date.issued2012en_US
dc.identifier.citationThe World Forum for Spine Research (WFSR 2012): The Intervertebral Disc - from Degeneration to Pain, Helsinki, Finland, 18-21 June 2012. In Global Spine Journal, 2012, v. 2 n. S1, no. P44en_US
dc.identifier.issn2192-5682-
dc.identifier.urihttp://hdl.handle.net/10722/153036-
dc.description.abstractINTRODUCTION: In humans, the almost total disappearance of notochordal cells in the nucleus pulposus (NP) correlates with early degenerative changes in the intervertebral disk which include changes in the extracellular matrix (ECM). Recent cell lineage studies in mice suggest cells within the NP are derived from the early embryonic notochord. Since notochordal cells are surrounded by a rich ECM, the functions of the notochord and the NP are likely mediated via cell-matrix interactions. Integrin heterodimers are transmembrane proteins and are the major adhesion receptors that mediate cell-matrix interactions. They connect the ECM to the intracellular cytoskeleton and transduce bidirectional signals between the extracellular matrix and intracellular compartments. At least 24 integrin heterodimers have been identified, and among them receptors cont...-
dc.languageengen_US
dc.publisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.com/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=1351&category_id=90&option=com_virtuemart&Itemid=53-
dc.relation.ispartofGlobal Spine Journalen_US
dc.rightsGlobal Spine Journal. Copyright © Georg Thieme Verlag.-
dc.titleAn essential role for β1 integrin mediated cell-matrix interactions in the development and maintenance of the nucleus pulposusen_US
dc.typeConference_Paperen_US
dc.identifier.emailGuo, S: shzhguo@hkucc.hku.hken_US
dc.identifier.emailAu, SYK: h0294066@hku.hken_US
dc.identifier.emailChan, D: chand@hku.hken_US
dc.identifier.emailCheah, KSE: hrmbdkc@hku.hken_US
dc.identifier.authorityChan, D=rp00540en_US
dc.identifier.authorityCheah, KSE=rp00342en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1055/s-0032-1319924-
dc.identifier.hkuros200919en_US
dc.identifier.volume2-
dc.identifier.issueS1-
dc.publisher.placeGermany-
dc.customcontrol.immutablesml 130319-

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