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Article: Liver tumor-initiating cells as a therapeutic target for hepatocellular carcinoma

TitleLiver tumor-initiating cells as a therapeutic target for hepatocellular carcinoma
Authors
KeywordsChemoresistance
HCC
Self-renewal
Tumor-initiating cells
Tumorigenicity
Issue Date2013
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer letters, 2013, v. 338 n. 1, p. 101-109 How to Cite?
AbstractHepatocellular carcinoma (HCC) is a common malignancy worldwide and has poor prognosis. Existing treatment modalities, including surgery, chemotherapy, and radiofrequency ablation, which target tumor bulk, have demonstrated limited therapeutic efficacy. In the past 10years, accumulating evidence has supported the existence of cancer stem cells (CSCs) or tumor initiating cells (T-ICs) within tumors including HCC. Identification of liver T-ICs and the signaling pathways that they are involved in may shed light on novel therapeutic strategies against this deadly disease. In this review, we will discuss recent progresses made in the research of liver T-ICs with regard to identification, functional characterization, regulation and therapeutic implications.
Persistent Identifierhttp://hdl.handle.net/10722/152964
ISSN
2015 Impact Factor: 5.992
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, TKWen_US
dc.contributor.authorCheung, VCHen_US
dc.contributor.authorNg, IOLen_US
dc.date.accessioned2012-07-16T09:53:19Z-
dc.date.available2012-07-16T09:53:19Z-
dc.date.issued2013en_US
dc.identifier.citationCancer letters, 2013, v. 338 n. 1, p. 101-109en_US
dc.identifier.issn0304-3835-
dc.identifier.urihttp://hdl.handle.net/10722/152964-
dc.description.abstractHepatocellular carcinoma (HCC) is a common malignancy worldwide and has poor prognosis. Existing treatment modalities, including surgery, chemotherapy, and radiofrequency ablation, which target tumor bulk, have demonstrated limited therapeutic efficacy. In the past 10years, accumulating evidence has supported the existence of cancer stem cells (CSCs) or tumor initiating cells (T-ICs) within tumors including HCC. Identification of liver T-ICs and the signaling pathways that they are involved in may shed light on novel therapeutic strategies against this deadly disease. In this review, we will discuss recent progresses made in the research of liver T-ICs with regard to identification, functional characterization, regulation and therapeutic implications.-
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet-
dc.relation.ispartofCancer lettersen_US
dc.subjectChemoresistance-
dc.subjectHCC-
dc.subjectSelf-renewal-
dc.subjectTumor-initiating cells-
dc.subjectTumorigenicity-
dc.titleLiver tumor-initiating cells as a therapeutic target for hepatocellular carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailLee, TKW: tkwlee@hkucc.hku.hken_US
dc.identifier.emailCheung, VCH: h0994045@hku.hken_US
dc.identifier.emailNg, IOL: iolng@hku.hken_US
dc.identifier.authorityLee, KW=rp00447en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.canlet.2012.05.001-
dc.identifier.pmid22579789-
dc.identifier.scopuseid_2-s2.0-84882822844-
dc.identifier.hkuros201929en_US
dc.identifier.isiWOS:000324565800017-
dc.publisher.placeIreland-

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