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Article: Evaluation of serum antimullerian hormone and inhibin B concentrations in the differential diagnosis of secondary oligoamenorrhea

TitleEvaluation of serum antimullerian hormone and inhibin B concentrations in the differential diagnosis of secondary oligoamenorrhea
Authors
KeywordsAntimullerian hormone
hyperprolactinemia
hypogonadotrophic hypogonadism
inhibin B
polycystic ovary syndrome
premature ovarian failure
Issue Date2011
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnstert
Citation
Fertility And Sterility, 2011, v. 96 n. 3, p. 774-779 How to Cite?
AbstractObjective: To evaluate the performance of antimullerian hormone (AMH) and inhibin B as ovarian function markers for differentiating common causes of secondary oligoamenorrhea, namely hypogonadotrophic hypogonadism (HH), polycystic ovary syndrome (PCOS), premature ovarian failure (POF), and hyperprolactinemia (HPRL). Design: Retrospective analysis. Setting: Two university hospitals. Patient(s): A total of 124 women with secondary oligoamenorrhea and 26 women with normal ovulation. Intervention(s): Serum samples from the subjects were analyzed for AMH and inhibin B. Main Outcome Measure(s): Serum AMH and inhibin B concentrations. Result(s): Serum AMH concentration was significantly raised in women having World Health Organization group 2 anovulation, either with or without PCOS, and was significantly decreased to very low levels in POF; the diagnostic accuracy in both conditions was excellent, with areas under the receiver operating characteristic curve (AUC) of 0.913 and 0.977, respectively. The discriminatory performance between HH and PCOS was also good, with AUC 0.861. AMH remained unchanged in HH and HPRL compared with ovulatory control subjects. There were large overlap of serum inhibin B levels in the different conditions, and a significant difference from control subjects existed only in the POF group. Conclusion(s): Serum AMH, but not inhibin B concentration, serves as a useful diagnostic tool in the differential diagnosis of secondary oligoamenorrhea. Copyright © 2011 American Society for Reproductive Medicine, Published by Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/152945
ISSN
2015 Impact Factor: 4.426
2015 SCImago Journal Rankings: 2.156
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, HWRen_HK
dc.contributor.authorAnderson, RAen_HK
dc.contributor.authorYeung, WSBen_HK
dc.contributor.authorHo, PCen_HK
dc.contributor.authorNg, EHYen_HK
dc.date.accessioned2012-07-16T09:52:55Z-
dc.date.available2012-07-16T09:52:55Z-
dc.date.issued2011en_HK
dc.identifier.citationFertility And Sterility, 2011, v. 96 n. 3, p. 774-779en_HK
dc.identifier.issn0015-0282en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152945-
dc.description.abstractObjective: To evaluate the performance of antimullerian hormone (AMH) and inhibin B as ovarian function markers for differentiating common causes of secondary oligoamenorrhea, namely hypogonadotrophic hypogonadism (HH), polycystic ovary syndrome (PCOS), premature ovarian failure (POF), and hyperprolactinemia (HPRL). Design: Retrospective analysis. Setting: Two university hospitals. Patient(s): A total of 124 women with secondary oligoamenorrhea and 26 women with normal ovulation. Intervention(s): Serum samples from the subjects were analyzed for AMH and inhibin B. Main Outcome Measure(s): Serum AMH and inhibin B concentrations. Result(s): Serum AMH concentration was significantly raised in women having World Health Organization group 2 anovulation, either with or without PCOS, and was significantly decreased to very low levels in POF; the diagnostic accuracy in both conditions was excellent, with areas under the receiver operating characteristic curve (AUC) of 0.913 and 0.977, respectively. The discriminatory performance between HH and PCOS was also good, with AUC 0.861. AMH remained unchanged in HH and HPRL compared with ovulatory control subjects. There were large overlap of serum inhibin B levels in the different conditions, and a significant difference from control subjects existed only in the POF group. Conclusion(s): Serum AMH, but not inhibin B concentration, serves as a useful diagnostic tool in the differential diagnosis of secondary oligoamenorrhea. Copyright © 2011 American Society for Reproductive Medicine, Published by Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnsterten_HK
dc.relation.ispartofFertility and Sterilityen_HK
dc.subjectAntimullerian hormoneen_HK
dc.subjecthyperprolactinemiaen_HK
dc.subjecthypogonadotrophic hypogonadismen_HK
dc.subjectinhibin Ben_HK
dc.subjectpolycystic ovary syndromeen_HK
dc.subjectpremature ovarian failureen_HK
dc.subject.meshAdolescent-
dc.subject.meshAnti-Mullerian Hormone - blood-
dc.subject.meshBiological Markers - blood-
dc.subject.meshInhibins - blood-
dc.subject.meshOligomenorrhea - blood - diagnosis - etiology-
dc.titleEvaluation of serum antimullerian hormone and inhibin B concentrations in the differential diagnosis of secondary oligoamenorrheaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0015-0282&volume=96&spage=774&epage=779&date=2011&atitle=Evaluation+of+serum+antimullerian+hormone+and+inhibin+B+concentrations+in+the+differential+diagnosis+of+secondary+oligoamenorrheaen_US
dc.identifier.emailLi, HWR: raymondli@hku.hken_HK
dc.identifier.emailYeung, WSB: wsbyeung@hkucc.hku.hken_HK
dc.identifier.emailHo, PC: pcho@hku.hken_HK
dc.identifier.emailNg, EHY: nghye@hku.hken_HK
dc.identifier.authorityLi, HWR=rp01649en_HK
dc.identifier.authorityYeung, WSB=rp00331en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.identifier.authorityNg, EHY=rp00426en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.fertnstert.2011.06.016en_HK
dc.identifier.pmid21737073-
dc.identifier.scopuseid_2-s2.0-80052273986en_HK
dc.identifier.hkuros201401en_US
dc.identifier.hkuros222177-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052273986&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume96en_HK
dc.identifier.issue3en_HK
dc.identifier.spage774en_HK
dc.identifier.epage779en_HK
dc.identifier.isiWOS:000294417000061-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, HWR=8554164300en_HK
dc.identifier.scopusauthoridAnderson, RA=35408622600en_HK
dc.identifier.scopusauthoridYeung, WSB=7102370745en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK
dc.identifier.scopusauthoridNg, EHY=35238184300en_HK
dc.identifier.citeulike9530119-

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