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Article: Improved surgical safety after laparoscopic compared to open surgery for apparent early stage endometrial cancer: Results from a randomised controlled trial

TitleImproved surgical safety after laparoscopic compared to open surgery for apparent early stage endometrial cancer: Results from a randomised controlled trial
Authors
KeywordsEndometrial cancer
Safety
Surgery
Issue Date2012
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ejca
Citation
European Journal Of Cancer, 2012, v. 48 n. 8, p. 1147-1153 How to Cite?
AbstractAim: To compare Total Laparoscopic Hysterectomy (TLH) and Total Abdominal Hysterectomy (TAH) with regard to surgical safety. Methods: Between October 2005 and June 2010, 760 patients with apparent early stage endometrial cancer were enroled in a multicentre, randomised clinical trial (LACE) comparing outcomes following TLH or TAH. The main study end points for this analysis were surgical adverse events (AE), hospital length of stay, conversion from laparoscopy to laparotomy, including 753 patients who completed at least 6 weeks of follow-up. Postoperative AEs were graded according to Common Toxicity Criteria (V3), and those immediately life-threatening, requiring inpatient hospitalisation or prolonged hospitalisation, or resulting in persistent or significant disability/incapacity were regarded as serious AEs. Results: The incidence of intra-operative AEs was comparable in either group. The incidence of post-operative AE CTC grade 3+ (18.6% in TAH, 12.9% in TLH, p 0.03) and serious AE (14.3% in TAH, 8.2% in TLH, p 0.007) was significantly higher in the TAH group compared to the TLH group. Mean operating time was 132 and 107 min, and median length of hospital stay was 2 and 5 days in the TLH and TAH group, respectively (p < 0.0001). The decline of haemoglobin from baseline to day 1 postoperatively was 2 g/L less in the TLH group (p 0.006). Conclusions: Compared to TAH, TLH is associated with a significantly decreased risk of major surgical AEs. A laparoscopic surgical approach to early stage endometrial cancer is safe. © 2011 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/152941
ISSN
2015 Impact Factor: 6.163
2015 SCImago Journal Rankings: 3.152
ISI Accession Number ID
Funding AgencyGrant Number
Cancer Council Queensland
Cancer Council New South Wales
Cancer Council Victoria
Cancer Council Western Australia
NHMRC456110
Cancer Australia Project Grant631523
Women and Infants Research Foundation, Western Australia
Royal Brisbane and Women's Hospital Foundation
Wesley Research Institute
Gallipoli Research Foundation
Gynetech
TYCO Healthcare, Australia
Johnson and Johnson Medical, Australia
Hunter New England Centre for Gynaecological Cancer
Genesis Oncology Trust
QLD Health
Funding Information:

The LACE trial was funded by Cancer Council Queensland, Cancer Council New South Wales, Cancer Council Victoria, Cancer Council Western Australia; NHMRC Project Grant 456110; Cancer Australia Project Grant 631523; The Women and Infants Research Foundation, Western Australia; Royal Brisbane and Women's Hospital Foundation; Wesley Research Institute; Gallipoli Research Foundation; Gynetech; TYCO Healthcare, Australia; Johnson and Johnson Medical, Australia; Hunter New England Centre for Gynaecological Cancer; Genesis Oncology Trust; and Smart Health Research Grant/QLD Health.

References

 

DC FieldValueLanguage
dc.contributor.authorObermair, Aen_HK
dc.contributor.authorJanda, Men_HK
dc.contributor.authorBaker, Jen_HK
dc.contributor.authorKondalsamyChennakesavan, Sen_HK
dc.contributor.authorBrand, Aen_HK
dc.contributor.authorHogg, Ren_HK
dc.contributor.authorJobling, TWen_HK
dc.contributor.authorLand, Ren_HK
dc.contributor.authorManolitsas, Ten_HK
dc.contributor.authorNascimento, Men_HK
dc.contributor.authorNeesham, Den_HK
dc.contributor.authorNicklin, JLen_HK
dc.contributor.authorOehler, MKen_HK
dc.contributor.authorOtton, Gen_HK
dc.contributor.authorPerrin, Len_HK
dc.contributor.authorSalfinger, Sen_HK
dc.contributor.authorHammond, Ien_HK
dc.contributor.authorLeung, Yen_HK
dc.contributor.authorSykes, Pen_HK
dc.contributor.authorNgan, Hen_HK
dc.contributor.authorGarrett, Aen_HK
dc.contributor.authorLaney, Men_HK
dc.contributor.authorNg, TYen_HK
dc.contributor.authorTam, Ken_HK
dc.contributor.authorChan, Ken_HK
dc.contributor.authorWrede, DHen_HK
dc.contributor.authorPather, Sen_HK
dc.contributor.authorSimcock, Ben_HK
dc.contributor.authorFarrell, Ren_HK
dc.contributor.authorRobertson, Gen_HK
dc.contributor.authorWalker, Gen_HK
dc.contributor.authorMcCartney, Aen_HK
dc.contributor.authorGebski, Ven_HK
dc.date.accessioned2012-07-16T09:52:54Z-
dc.date.available2012-07-16T09:52:54Z-
dc.date.issued2012en_HK
dc.identifier.citationEuropean Journal Of Cancer, 2012, v. 48 n. 8, p. 1147-1153en_HK
dc.identifier.issn0959-8049en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152941-
dc.description.abstractAim: To compare Total Laparoscopic Hysterectomy (TLH) and Total Abdominal Hysterectomy (TAH) with regard to surgical safety. Methods: Between October 2005 and June 2010, 760 patients with apparent early stage endometrial cancer were enroled in a multicentre, randomised clinical trial (LACE) comparing outcomes following TLH or TAH. The main study end points for this analysis were surgical adverse events (AE), hospital length of stay, conversion from laparoscopy to laparotomy, including 753 patients who completed at least 6 weeks of follow-up. Postoperative AEs were graded according to Common Toxicity Criteria (V3), and those immediately life-threatening, requiring inpatient hospitalisation or prolonged hospitalisation, or resulting in persistent or significant disability/incapacity were regarded as serious AEs. Results: The incidence of intra-operative AEs was comparable in either group. The incidence of post-operative AE CTC grade 3+ (18.6% in TAH, 12.9% in TLH, p 0.03) and serious AE (14.3% in TAH, 8.2% in TLH, p 0.007) was significantly higher in the TAH group compared to the TLH group. Mean operating time was 132 and 107 min, and median length of hospital stay was 2 and 5 days in the TLH and TAH group, respectively (p < 0.0001). The decline of haemoglobin from baseline to day 1 postoperatively was 2 g/L less in the TLH group (p 0.006). Conclusions: Compared to TAH, TLH is associated with a significantly decreased risk of major surgical AEs. A laparoscopic surgical approach to early stage endometrial cancer is safe. © 2011 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ejcaen_HK
dc.relation.ispartofEuropean Journal of Canceren_HK
dc.subjectEndometrial canceren_HK
dc.subjectSafetyen_HK
dc.subjectSurgeryen_HK
dc.titleImproved surgical safety after laparoscopic compared to open surgery for apparent early stage endometrial cancer: Results from a randomised controlled trialen_HK
dc.typeArticleen_HK
dc.identifier.emailNgan, H:hysngan@hkucc.hku.hken_HK
dc.identifier.authorityNgan, H=rp00346en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejca.2012.02.055en_HK
dc.identifier.pmid22548907-
dc.identifier.scopuseid_2-s2.0-84860484987en_HK
dc.identifier.hkuros201372en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84860484987&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume48en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1147en_HK
dc.identifier.epage1153en_HK
dc.identifier.isiWOS:000303448200005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridObermair, A=7006307099en_HK
dc.identifier.scopusauthoridJanda, M=7005192283en_HK
dc.identifier.scopusauthoridBaker, J=54782088700en_HK
dc.identifier.scopusauthoridKondalsamyChennakesavan, S=8868800300en_HK
dc.identifier.scopusauthoridBrand, A=23027063200en_HK
dc.identifier.scopusauthoridHogg, R=7201804395en_HK
dc.identifier.scopusauthoridJobling, TW=26643402000en_HK
dc.identifier.scopusauthoridLand, R=7004935541en_HK
dc.identifier.scopusauthoridManolitsas, T=6603060633en_HK
dc.identifier.scopusauthoridNascimento, M=8632338600en_HK
dc.identifier.scopusauthoridNeesham, D=6507268632en_HK
dc.identifier.scopusauthoridNicklin, JL=35240667700en_HK
dc.identifier.scopusauthoridOehler, MK=7004087012en_HK
dc.identifier.scopusauthoridOtton, G=25637701500en_HK
dc.identifier.scopusauthoridPerrin, L=35415718900en_HK
dc.identifier.scopusauthoridSalfinger, S=6504323465en_HK
dc.identifier.scopusauthoridHammond, I=7004849540en_HK
dc.identifier.scopusauthoridLeung, Y=7201463926en_HK
dc.identifier.scopusauthoridSykes, P=7101668541en_HK
dc.identifier.scopusauthoridNgan, H=34571944100en_HK
dc.identifier.scopusauthoridGarrett, A=7006787646en_HK
dc.identifier.scopusauthoridLaney, M=6603586390en_HK
dc.identifier.scopusauthoridNg, TY=7402229853en_HK
dc.identifier.scopusauthoridTam, K=55203241900en_HK
dc.identifier.scopusauthoridChan, K=25622512400en_HK
dc.identifier.scopusauthoridWrede, DH=55177795900en_HK
dc.identifier.scopusauthoridPather, S=8862538000en_HK
dc.identifier.scopusauthoridSimcock, B=26538079400en_HK
dc.identifier.scopusauthoridFarrell, R=33067922800en_HK
dc.identifier.scopusauthoridRobertson, G=7402368496en_HK
dc.identifier.scopusauthoridWalker, G=55152524400en_HK
dc.identifier.scopusauthoridMcCartney, A=7004310422en_HK
dc.identifier.scopusauthoridGebski, V=16233175200en_HK
dc.identifier.citeulike10645127-

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