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Article: Risk factors to predict the incidence of surgical adverse events following open or laparoscopic surgery for apparent early stage endometrial cancer: Results from a randomised controlled trial

TitleRisk factors to predict the incidence of surgical adverse events following open or laparoscopic surgery for apparent early stage endometrial cancer: Results from a randomised controlled trial
Authors
KeywordsEndometrial cancer
Risk factors
Safety
Surgery
Issue Date2012
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ejca
Citation
European Journal Of Cancer, 2012, v. 48 n. 14, p. 2155-2162 How to Cite?
AbstractAims: To identify risk factors for major adverse events (AEs) and to develop a nomogram to predict the probability of such AEs in patients who have surgery for apparent early stage endometrial cancer. Methods: We used data from 753 patients who were randomised to either total laparoscopic hysterectomy or total abdominal hysterectomy in the LACE trial. Serious adverse events that prolonged hospital stay or postoperative adverse events (using common terminology criteria 3+, CTCAE V3) were considered major AEs. We analysed pre-surgical characteristics that were associated with the risk of developing major AEs by multivariate logistic regression. We identified a parsimonious model by backward stepwise logistic regression. The six most significant or clinically important variables were included in the nomogram to predict the risk of major AEs within 6 weeks of surgery and the nomogram was internally validated. Results: Overall, 132 (17.5%) patients had at least one major AE. An open surgical approach (laparotomy), higher Charlson's medical co-morbidities score, moderately differentiated tumours on curettings, higher baseline Eastern Cooperative Oncology Group (ECOG) score, higher body mass index and low haemoglobin levels were associated with AE and were used in the nomogram. The bootstrap corrected concordance index of the nomogram was 0.63 and it showed good calibration. Conclusions: Six pre-surgical factors independently predicted the risk of major AEs. This research might form the basis to develop risk reduction strategies to minimise the risk of AEs among patients undergoing surgery for apparent early stage endometrial cancer. © 2012 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/152940
ISSN
2015 Impact Factor: 6.163
2015 SCImago Journal Rankings: 3.152
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKondalsamyChennakesavan, Sen_HK
dc.contributor.authorJanda, Men_HK
dc.contributor.authorGebski, Ven_HK
dc.contributor.authorBaker, Jen_HK
dc.contributor.authorBrand, Aen_HK
dc.contributor.authorHogg, Ren_HK
dc.contributor.authorJobling, TWen_HK
dc.contributor.authorLand, Ren_HK
dc.contributor.authorManolitsas, Ten_HK
dc.contributor.authorNascimento, Men_HK
dc.contributor.authorNeesham, Den_HK
dc.contributor.authorNicklin, JLen_HK
dc.contributor.authorOehler, MKen_HK
dc.contributor.authorOtton, Gen_HK
dc.contributor.authorPerrin, Len_HK
dc.contributor.authorSalfinger, Sen_HK
dc.contributor.authorHammond, Ien_HK
dc.contributor.authorLeung, Yen_HK
dc.contributor.authorSykes, Pen_HK
dc.contributor.authorNgan, Hen_HK
dc.contributor.authorGarrett, Aen_HK
dc.contributor.authorLaney, Men_HK
dc.contributor.authorNg, TYen_HK
dc.contributor.authorTam, Ken_HK
dc.contributor.authorChan, Ken_HK
dc.contributor.authorWrede, DHen_HK
dc.contributor.authorPather, Sen_HK
dc.contributor.authorSimcock, Ben_HK
dc.contributor.authorFarrell, Ren_HK
dc.contributor.authorRobertson, Gen_HK
dc.contributor.authorWalker, Gen_HK
dc.contributor.authorMcCartney, Aen_HK
dc.contributor.authorObermair, Aen_HK
dc.date.accessioned2012-07-16T09:52:52Z-
dc.date.available2012-07-16T09:52:52Z-
dc.date.issued2012en_HK
dc.identifier.citationEuropean Journal Of Cancer, 2012, v. 48 n. 14, p. 2155-2162en_HK
dc.identifier.issn0959-8049en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152940-
dc.description.abstractAims: To identify risk factors for major adverse events (AEs) and to develop a nomogram to predict the probability of such AEs in patients who have surgery for apparent early stage endometrial cancer. Methods: We used data from 753 patients who were randomised to either total laparoscopic hysterectomy or total abdominal hysterectomy in the LACE trial. Serious adverse events that prolonged hospital stay or postoperative adverse events (using common terminology criteria 3+, CTCAE V3) were considered major AEs. We analysed pre-surgical characteristics that were associated with the risk of developing major AEs by multivariate logistic regression. We identified a parsimonious model by backward stepwise logistic regression. The six most significant or clinically important variables were included in the nomogram to predict the risk of major AEs within 6 weeks of surgery and the nomogram was internally validated. Results: Overall, 132 (17.5%) patients had at least one major AE. An open surgical approach (laparotomy), higher Charlson's medical co-morbidities score, moderately differentiated tumours on curettings, higher baseline Eastern Cooperative Oncology Group (ECOG) score, higher body mass index and low haemoglobin levels were associated with AE and were used in the nomogram. The bootstrap corrected concordance index of the nomogram was 0.63 and it showed good calibration. Conclusions: Six pre-surgical factors independently predicted the risk of major AEs. This research might form the basis to develop risk reduction strategies to minimise the risk of AEs among patients undergoing surgery for apparent early stage endometrial cancer. © 2012 Elsevier Ltd.en_HK
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/ejcaen_HK
dc.relation.ispartofEuropean Journal of Canceren_HK
dc.subjectEndometrial canceren_HK
dc.subjectRisk factorsen_HK
dc.subjectSafetyen_HK
dc.subjectSurgeryen_HK
dc.titleRisk factors to predict the incidence of surgical adverse events following open or laparoscopic surgery for apparent early stage endometrial cancer: Results from a randomised controlled trialen_HK
dc.typeArticleen_HK
dc.identifier.emailNgan, H:hysngan@hkucc.hku.hken_HK
dc.identifier.authorityNgan, H=rp00346en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejca.2012.03.013en_HK
dc.identifier.pmid22503396-
dc.identifier.scopuseid_2-s2.0-84865509990en_HK
dc.identifier.hkuros201369en_US
dc.identifier.isiWOS:000307884900007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKondalsamyChennakesavan, S=8868800300en_HK
dc.identifier.scopusauthoridJanda, M=7005192283en_HK
dc.identifier.scopusauthoridGebski, V=16233175200en_HK
dc.identifier.scopusauthoridBaker, J=54782088700en_HK
dc.identifier.scopusauthoridBrand, A=23027063200en_HK
dc.identifier.scopusauthoridHogg, R=7201804395en_HK
dc.identifier.scopusauthoridJobling, TW=26643402000en_HK
dc.identifier.scopusauthoridLand, R=7004935541en_HK
dc.identifier.scopusauthoridManolitsas, T=6603060633en_HK
dc.identifier.scopusauthoridNascimento, M=8632338600en_HK
dc.identifier.scopusauthoridNeesham, D=6507268632en_HK
dc.identifier.scopusauthoridNicklin, JL=35240667700en_HK
dc.identifier.scopusauthoridOehler, MK=7004087012en_HK
dc.identifier.scopusauthoridOtton, G=25637701500en_HK
dc.identifier.scopusauthoridPerrin, L=35415718900en_HK
dc.identifier.scopusauthoridSalfinger, S=6504323465en_HK
dc.identifier.scopusauthoridHammond, I=7004849540en_HK
dc.identifier.scopusauthoridLeung, Y=7201463926en_HK
dc.identifier.scopusauthoridSykes, P=7101668541en_HK
dc.identifier.scopusauthoridNgan, H=34571944100en_HK
dc.identifier.scopusauthoridGarrett, A=7006787646en_HK
dc.identifier.scopusauthoridLaney, M=6603586390en_HK
dc.identifier.scopusauthoridNg, TY=7402229853en_HK
dc.identifier.scopusauthoridTam, K=7201692816en_HK
dc.identifier.scopusauthoridChan, K=25622512400en_HK
dc.identifier.scopusauthoridWrede, DH=55177795900en_HK
dc.identifier.scopusauthoridPather, S=8862538000en_HK
dc.identifier.scopusauthoridSimcock, B=26538079400en_HK
dc.identifier.scopusauthoridFarrell, R=33067922800en_HK
dc.identifier.scopusauthoridRobertson, G=7402368496en_HK
dc.identifier.scopusauthoridWalker, G=55152524400en_HK
dc.identifier.scopusauthoridMcCartney, A=7004310422en_HK
dc.identifier.scopusauthoridObermair, A=7006307099en_HK
dc.identifier.citeulike10566919-

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