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Article: Clinical and cognitive correlates of insight in first-episode schizophrenia

TitleClinical and cognitive correlates of insight in first-episode schizophrenia
Authors
KeywordsCognitive function
First-episode schizophrenia
Insight
Symptomatology
Issue Date2012
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2012, v. 135 n. 1-3, p. 40-45 How to Cite?
AbstractThis study aims to explore the relationship between clinical symptoms and cognitive functions with different insight dimensions in patients with first-episode schizophrenia. Seventy-nine patients were assessed following six months of treatment. Insight was assessed using the abridged version of Scale of Unawareness of Mental Disorder (SUMD). Symptoms were assessed using Positive and Negative Syndrome Scale (PANSS). Cognitive functions were assessed using the Modified Wisconsin Card Sorting Test (MWCST), semantic verbal fluency and the letter-number sequencing (LNS) test from the Wechsler Adult Intelligence Scale (WAIS). Positive, negative and disorganized symptoms were found to be correlated with overall insight and all three general insight dimensions. Only perseverative errors and categories completed of MWCST were correlated with overall insight. Perseverative errors and non-perseverative errors of MWCST were correlated with the awareness of medication effects; perseverative errors of MWCST were also correlated with the awareness of social consequence of the illness. These support the link between poor insight and impaired executive function particularly measured by MWCST. The specific correlation of cognitive functions and different dimensions of insight suggests different underlying mechanism within each dimension of insight. The combined model of symptomatology and cognitive function explained 20.6% to 36.4% of the variance in the lack of insight within the different dimensions. The modest combined relationship of clinical and cognitive function with insight suggests that the exploration of other models in relationship to different insight dimensions is important. © 2011 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/152821
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, SKWen_HK
dc.contributor.authorChan, KKSen_HK
dc.contributor.authorLam, MMLen_HK
dc.contributor.authorChiu, CPYen_HK
dc.contributor.authorHui, CLMen_HK
dc.contributor.authorWong, GHYen_HK
dc.contributor.authorChang, WCen_HK
dc.contributor.authorChen, EYHen_HK
dc.date.accessioned2012-07-16T09:49:40Z-
dc.date.available2012-07-16T09:49:40Z-
dc.date.issued2012en_HK
dc.identifier.citationSchizophrenia Research, 2012, v. 135 n. 1-3, p. 40-45en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152821-
dc.description.abstractThis study aims to explore the relationship between clinical symptoms and cognitive functions with different insight dimensions in patients with first-episode schizophrenia. Seventy-nine patients were assessed following six months of treatment. Insight was assessed using the abridged version of Scale of Unawareness of Mental Disorder (SUMD). Symptoms were assessed using Positive and Negative Syndrome Scale (PANSS). Cognitive functions were assessed using the Modified Wisconsin Card Sorting Test (MWCST), semantic verbal fluency and the letter-number sequencing (LNS) test from the Wechsler Adult Intelligence Scale (WAIS). Positive, negative and disorganized symptoms were found to be correlated with overall insight and all three general insight dimensions. Only perseverative errors and categories completed of MWCST were correlated with overall insight. Perseverative errors and non-perseverative errors of MWCST were correlated with the awareness of medication effects; perseverative errors of MWCST were also correlated with the awareness of social consequence of the illness. These support the link between poor insight and impaired executive function particularly measured by MWCST. The specific correlation of cognitive functions and different dimensions of insight suggests different underlying mechanism within each dimension of insight. The combined model of symptomatology and cognitive function explained 20.6% to 36.4% of the variance in the lack of insight within the different dimensions. The modest combined relationship of clinical and cognitive function with insight suggests that the exploration of other models in relationship to different insight dimensions is important. © 2011 Elsevier B.V.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.subjectCognitive functionen_HK
dc.subjectFirst-episode schizophreniaen_HK
dc.subjectInsighten_HK
dc.subjectSymptomatologyen_HK
dc.subject.meshCognition Disorders - etiology-
dc.subject.meshSchizophrenia - complications-
dc.subject.meshSchizophrenic Psychology-
dc.subject.meshNeuropsychological Tests-
dc.subject.meshPsychiatric Status Rating Scales-
dc.titleClinical and cognitive correlates of insight in first-episode schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, MML: maylam11@hku.hken_HK
dc.identifier.emailChiu, CPY: chiupyc@hku.hken_HK
dc.identifier.emailChang, WC: changwc@hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.authorityLam, MML=rp00296en_HK
dc.identifier.authorityChiu, CPY=rp00291en_HK
dc.identifier.authorityChang, WC=rp01465en_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.schres.2011.12.013en_HK
dc.identifier.pmid22245186-
dc.identifier.scopuseid_2-s2.0-84857232441en_HK
dc.identifier.hkuros200875en_US
dc.identifier.hkuros233248-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84857232441&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume135en_HK
dc.identifier.issue1-3en_HK
dc.identifier.spage40en_HK
dc.identifier.epage45en_HK
dc.identifier.eissn1573-2509-
dc.identifier.isiWOS:000300940000007-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChan, SKW=55039018700en_HK
dc.identifier.scopusauthoridChan, KKS=36882457400en_HK
dc.identifier.scopusauthoridLam, MML=13106178700en_HK
dc.identifier.scopusauthoridChiu, CPY=8627115700en_HK
dc.identifier.scopusauthoridHui, CLM=35734149500en_HK
dc.identifier.scopusauthoridWong, GHY=24465754400en_HK
dc.identifier.scopusauthoridChang, WC=26643706700en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.citeulike10237376-

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