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Article: Duration of untreated psychosis: Relationship with baseline characteristics and three-year outcome in first-episode psychosis

TitleDuration of untreated psychosis: Relationship with baseline characteristics and three-year outcome in first-episode psychosis
Authors
KeywordsDuration of untreated psychosis
Employment
First-episode psychosis
Mode of onset
Outcome
Issue Date2012
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychres
Citation
Psychiatry Research, 2012, v. 198 n. 3, p. 360-365 How to Cite?
AbstractDuration of untreated psychosis (DUP) has been considered as one of the few potentially malleable prognostic factors in psychotic illness. The literature demonstrated that prolonged DUP predicted the level of positive symptoms, but its relationships with negative symptoms and functional outcome were less clear-cut. Thus far, most first-episode studies have been conducted in western countries. Yet, it is known that illness outcome might be modified by socio-cultural factors. In this study, we aimed to examine the impact of DUP on baseline characteristics, clinical and vocational outcomes over 3 years in 700 Chinese young people who presented with first-episode psychosis to a specialized early intervention service in Hong Kong. Our results showed that prolonged DUP was associated with male sex, younger age of onset, schizophrenia-spectrum diagnosis, insidious development of psychosis, fewer baseline positive symptoms and less likelihood of hospitalization at intake. Regression analyses revealed that prolonged DUP was significantly predictive of outcome on positive symptoms, recovery and sustained full-time employment in our first-episode psychosis cohort. Taken together, our study provided further supportive evidence regarding the prognostic value of DUP on illness outcome. Additionally, it suggested that an adverse impact of treatment delay for psychosis may likely be applied across regions of various ethno-cultural backgrounds. © 2012 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/152820
ISSN
2015 Impact Factor: 2.466
2015 SCImago Journal Rankings: 1.235
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChang, WCen_HK
dc.contributor.authorTang, JYMen_HK
dc.contributor.authorHui, CLMen_HK
dc.contributor.authorLam, MMLen_HK
dc.contributor.authorWong, GHYen_HK
dc.contributor.authorChan, SKWen_HK
dc.contributor.authorChiu, CPYen_HK
dc.contributor.authorChung, DWSen_HK
dc.contributor.authorLaw, CWen_HK
dc.contributor.authorTso, Sen_HK
dc.contributor.authorChan, Ken_HK
dc.contributor.authorHung, SFen_HK
dc.contributor.authorChen, EYHen_HK
dc.date.accessioned2012-07-16T09:49:39Z-
dc.date.available2012-07-16T09:49:39Z-
dc.date.issued2012en_HK
dc.identifier.citationPsychiatry Research, 2012, v. 198 n. 3, p. 360-365en_HK
dc.identifier.issn0165-1781en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152820-
dc.description.abstractDuration of untreated psychosis (DUP) has been considered as one of the few potentially malleable prognostic factors in psychotic illness. The literature demonstrated that prolonged DUP predicted the level of positive symptoms, but its relationships with negative symptoms and functional outcome were less clear-cut. Thus far, most first-episode studies have been conducted in western countries. Yet, it is known that illness outcome might be modified by socio-cultural factors. In this study, we aimed to examine the impact of DUP on baseline characteristics, clinical and vocational outcomes over 3 years in 700 Chinese young people who presented with first-episode psychosis to a specialized early intervention service in Hong Kong. Our results showed that prolonged DUP was associated with male sex, younger age of onset, schizophrenia-spectrum diagnosis, insidious development of psychosis, fewer baseline positive symptoms and less likelihood of hospitalization at intake. Regression analyses revealed that prolonged DUP was significantly predictive of outcome on positive symptoms, recovery and sustained full-time employment in our first-episode psychosis cohort. Taken together, our study provided further supportive evidence regarding the prognostic value of DUP on illness outcome. Additionally, it suggested that an adverse impact of treatment delay for psychosis may likely be applied across regions of various ethno-cultural backgrounds. © 2012 Elsevier Ltd.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychresen_HK
dc.relation.ispartofPsychiatry Researchen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Psychiatry Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Psychiatry Research, [VOL 198, ISSUE 3, 2012] DOI 10.1016/j.psychres.2011.09.006-
dc.subjectDuration of untreated psychosisen_HK
dc.subjectEmploymenten_HK
dc.subjectFirst-episode psychosisen_HK
dc.subjectMode of onseten_HK
dc.subjectOutcomeen_HK
dc.titleDuration of untreated psychosis: Relationship with baseline characteristics and three-year outcome in first-episode psychosisen_HK
dc.typeArticleen_HK
dc.identifier.emailChang, WC: changwc@hku.hken_HK
dc.identifier.emailLam, MML: maylam11@hku.hken_HK
dc.identifier.emailChiu, CPY: chiupyc@hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.authorityChang, WC=rp01465en_HK
dc.identifier.authorityLam, MML=rp00296en_HK
dc.identifier.authorityChiu, CPY=rp00291en_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.psychres.2011.09.006en_HK
dc.identifier.pmid22425475-
dc.identifier.scopuseid_2-s2.0-84868665081en_HK
dc.identifier.hkuros200871en_US
dc.identifier.hkuros233247-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84868665081&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume198en_HK
dc.identifier.issue3en_HK
dc.identifier.spage360en_HK
dc.identifier.epage365en_HK
dc.identifier.isiWOS:000312044800004-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridChang, WC=26643706700en_HK
dc.identifier.scopusauthoridTang, JYM=35086815700en_HK
dc.identifier.scopusauthoridHui, CLM=35734149500en_HK
dc.identifier.scopusauthoridLam, MML=13106178700en_HK
dc.identifier.scopusauthoridWong, GHY=24465754400en_HK
dc.identifier.scopusauthoridChan, SKW=55039018700en_HK
dc.identifier.scopusauthoridChiu, CPY=8627115700en_HK
dc.identifier.scopusauthoridChung, DWS=7401719312en_HK
dc.identifier.scopusauthoridLaw, CW=8627115600en_HK
dc.identifier.scopusauthoridTso, S=25229476600en_HK
dc.identifier.scopusauthoridChan, K=16204769300en_HK
dc.identifier.scopusauthoridHung, SF=7201936267en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.citeulike10471856-

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