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Article: Rising epidemic of HIV-1 infections among general populations in Fujian, China

TitleRising epidemic of HIV-1 infections among general populations in Fujian, China
Authors
Issue Date2012
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jaids.com
Citation
Journal Of Acquired Immune Deficiency Syndromes, 2012, v. 60 n. 3, p. 328-335 How to Cite?
AbstractBackground: HIV-1 infections have increased significantly with a doubled number of cases identified between 2006-2007 and 2008-2009 in Fujian, a southeastern province of China. No study has investigated the cause and the evolving epidemic there. Methods: In a province-wide study of recently identified infections from 2006 to 2009, we sought to investigate the rising epidemic of HIV-1 infections among general populations and conducted a molecular epidemiology study to determine the new trends of HIV-1 evolution there. Results: About 915,830 and 2,152,658 specimens collected in 2006-2007 and 2008-2009 were tested for HIV-1 infection. We found that the overall prevalence of infections elevated from 0.064% in 2006-2007 to 0.074% in 2008-2009 (P = 0.003). A high frequency of HIV-1 infections was consistently related to unprotected heterosexual transmissions compared with other risk groups such as intravenous drug users. Critically, the prevalence rate had significantly increased in recent years among general populations such as voluntary blood donors (P < 0.001), recipients of blood transfusion (P < 0.001) and people during presurgery screening (P < 0.001). Besides CRF01-AE as the major circulating subtype (61/86, 70.9%), 25 non-CRF01-AE strains were found contributing to increased HIV-1 genetic diversity including C/CRF07-BC/CRF08-BC (5.8%), B/B' (15.1%), unique recombinant forms (8.1%), and some minor drug-resistant variants. Conclusions: Increased prevalence of HIV-1 infections among general populations likely accounts for the rising epidemic in recent years in Fujian. The epidemic was no longer dictated by CRF01-AE but rather by multisubtype viruses. Our findings call for an enhanced surveillance system and have implications to strategic prevention programs among general populations. © 2012 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/152764
ISSN
2014 Impact Factor: 4.556
ISI Accession Number ID
Funding AgencyGrant Number
China governmental agency
HKU-UDF
LSK Faculty of Medicine
HKU201007176151
China's Major Project of the National Science and Technology2012ZX10001-009
Funding Information:

The authors are indebted to all study participants. The authors thank all health workers at Fujian 220 HIV-1 testing sites for initial screening tests. The authors thank China governmental agency for financial supports to Fujian and Fuzhou Center for Disease Control and Preventions.

References

 

DC FieldValueLanguage
dc.contributor.authorYao, Xen_HK
dc.contributor.authorWang, Hen_HK
dc.contributor.authorYan, Pen_HK
dc.contributor.authorLu, Yen_HK
dc.contributor.authorLin, Hen_HK
dc.contributor.authorChen, Len_HK
dc.contributor.authorNg, Jen_HK
dc.contributor.authorLau, Een_HK
dc.contributor.authorLiu, Len_HK
dc.contributor.authorWu, Jen_HK
dc.contributor.authorChen, Zen_HK
dc.date.accessioned2012-07-16T09:47:56Z-
dc.date.available2012-07-16T09:47:56Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Acquired Immune Deficiency Syndromes, 2012, v. 60 n. 3, p. 328-335en_HK
dc.identifier.issn1525-4135en_HK
dc.identifier.urihttp://hdl.handle.net/10722/152764-
dc.description.abstractBackground: HIV-1 infections have increased significantly with a doubled number of cases identified between 2006-2007 and 2008-2009 in Fujian, a southeastern province of China. No study has investigated the cause and the evolving epidemic there. Methods: In a province-wide study of recently identified infections from 2006 to 2009, we sought to investigate the rising epidemic of HIV-1 infections among general populations and conducted a molecular epidemiology study to determine the new trends of HIV-1 evolution there. Results: About 915,830 and 2,152,658 specimens collected in 2006-2007 and 2008-2009 were tested for HIV-1 infection. We found that the overall prevalence of infections elevated from 0.064% in 2006-2007 to 0.074% in 2008-2009 (P = 0.003). A high frequency of HIV-1 infections was consistently related to unprotected heterosexual transmissions compared with other risk groups such as intravenous drug users. Critically, the prevalence rate had significantly increased in recent years among general populations such as voluntary blood donors (P < 0.001), recipients of blood transfusion (P < 0.001) and people during presurgery screening (P < 0.001). Besides CRF01-AE as the major circulating subtype (61/86, 70.9%), 25 non-CRF01-AE strains were found contributing to increased HIV-1 genetic diversity including C/CRF07-BC/CRF08-BC (5.8%), B/B' (15.1%), unique recombinant forms (8.1%), and some minor drug-resistant variants. Conclusions: Increased prevalence of HIV-1 infections among general populations likely accounts for the rising epidemic in recent years in Fujian. The epidemic was no longer dictated by CRF01-AE but rather by multisubtype viruses. Our findings call for an enhanced surveillance system and have implications to strategic prevention programs among general populations. © 2012 Lippincott Williams & Wilkins.en_HK
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jaids.comen_HK
dc.relation.ispartofJournal of Acquired Immune Deficiency Syndromesen_HK
dc.subject.meshAdulten_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshDrug Resistance, Viral - geneticsen_HK
dc.subject.meshEpidemicsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGenes, gagen_HK
dc.subject.meshGenes, polen_HK
dc.subject.meshHIV Infections - complications - epidemiology - virologyen_HK
dc.subject.meshHIV-1 - classification - drug effects - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMutationen_HK
dc.subject.meshPhylogenyen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshPregnancy Complications, Infectious - epidemiologyen_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshRecombination, Geneticen_HK
dc.subject.meshYoung Adulten_HK
dc.titleRising epidemic of HIV-1 infections among general populations in Fujian, Chinaen_HK
dc.typeArticleen_HK
dc.identifier.emailLiu, L: liuli71@hkucc.hku.hken_HK
dc.identifier.authorityLiu, L=rp00268en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/QAI.0b013e31824f19f5en_HK
dc.identifier.pmid22343181en_HK
dc.identifier.scopuseid_2-s2.0-84864321588en_HK
dc.identifier.hkuros200529en_US
dc.identifier.hkuros206327-
dc.identifier.hkuros225305-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84864321588&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume60en_HK
dc.identifier.issue3en_HK
dc.identifier.spage328en_HK
dc.identifier.epage335en_HK
dc.identifier.isiWOS:000305804400026-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYao, X=54979447500en_HK
dc.identifier.scopusauthoridWang, H=54977057300en_HK
dc.identifier.scopusauthoridYan, P=54975666100en_HK
dc.identifier.scopusauthoridLu, Y=54975573200en_HK
dc.identifier.scopusauthoridLin, H=54971703700en_HK
dc.identifier.scopusauthoridChen, L=54981132700en_HK
dc.identifier.scopusauthoridNg, J=54980508000en_HK
dc.identifier.scopusauthoridLau, E=54979255700en_HK
dc.identifier.scopusauthoridLiu, L=35784425200en_HK
dc.identifier.scopusauthoridWu, J=54980333200en_HK
dc.identifier.scopusauthoridChen, Z=54974073200en_HK

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