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Article: Rising epidemic of HIV-1 infections among general populations in Fujian, China
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TitleRising epidemic of HIV-1 infections among general populations in Fujian, China
 
AuthorsYao, X1 3
Wang, H1
Yan, P2
Lu, Y3
Lin, H3
Chen, L2
Ng, J1
Lau, E1
Liu, L1
Wu, J1
Chen, Z1 4
 
Issue Date2012
 
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jaids.com
 
CitationJournal Of Acquired Immune Deficiency Syndromes, 2012, v. 60 n. 3, p. 328-335 [How to Cite?]
DOI: http://dx.doi.org/10.1097/QAI.0b013e31824f19f5
 
AbstractBackground: HIV-1 infections have increased significantly with a doubled number of cases identified between 2006-2007 and 2008-2009 in Fujian, a southeastern province of China. No study has investigated the cause and the evolving epidemic there. Methods: In a province-wide study of recently identified infections from 2006 to 2009, we sought to investigate the rising epidemic of HIV-1 infections among general populations and conducted a molecular epidemiology study to determine the new trends of HIV-1 evolution there. Results: About 915,830 and 2,152,658 specimens collected in 2006-2007 and 2008-2009 were tested for HIV-1 infection. We found that the overall prevalence of infections elevated from 0.064% in 2006-2007 to 0.074% in 2008-2009 (P = 0.003). A high frequency of HIV-1 infections was consistently related to unprotected heterosexual transmissions compared with other risk groups such as intravenous drug users. Critically, the prevalence rate had significantly increased in recent years among general populations such as voluntary blood donors (P < 0.001), recipients of blood transfusion (P < 0.001) and people during presurgery screening (P < 0.001). Besides CRF01-AE as the major circulating subtype (61/86, 70.9%), 25 non-CRF01-AE strains were found contributing to increased HIV-1 genetic diversity including C/CRF07-BC/CRF08-BC (5.8%), B/B' (15.1%), unique recombinant forms (8.1%), and some minor drug-resistant variants. Conclusions: Increased prevalence of HIV-1 infections among general populations likely accounts for the rising epidemic in recent years in Fujian. The epidemic was no longer dictated by CRF01-AE but rather by multisubtype viruses. Our findings call for an enhanced surveillance system and have implications to strategic prevention programs among general populations. © 2012 Lippincott Williams & Wilkins.
 
ISSN1525-4135
2013 Impact Factor: 4.394
 
DOIhttp://dx.doi.org/10.1097/QAI.0b013e31824f19f5
 
ISI Accession Number IDWOS:000305804400026
Funding AgencyGrant Number
China governmental agency
HKU-UDF
LSK Faculty of Medicine
HKU201007176151
China's Major Project of the National Science and Technology2012ZX10001-009
Funding Information:

The authors are indebted to all study participants. The authors thank all health workers at Fujian 220 HIV-1 testing sites for initial screening tests. The authors thank China governmental agency for financial supports to Fujian and Fuzhou Center for Disease Control and Preventions.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorYao, X
 
dc.contributor.authorWang, H
 
dc.contributor.authorYan, P
 
dc.contributor.authorLu, Y
 
dc.contributor.authorLin, H
 
dc.contributor.authorChen, L
 
dc.contributor.authorNg, J
 
dc.contributor.authorLau, E
 
dc.contributor.authorLiu, L
 
dc.contributor.authorWu, J
 
dc.contributor.authorChen, Z
 
dc.date.accessioned2012-07-16T09:47:56Z
 
dc.date.available2012-07-16T09:47:56Z
 
dc.date.issued2012
 
dc.description.abstractBackground: HIV-1 infections have increased significantly with a doubled number of cases identified between 2006-2007 and 2008-2009 in Fujian, a southeastern province of China. No study has investigated the cause and the evolving epidemic there. Methods: In a province-wide study of recently identified infections from 2006 to 2009, we sought to investigate the rising epidemic of HIV-1 infections among general populations and conducted a molecular epidemiology study to determine the new trends of HIV-1 evolution there. Results: About 915,830 and 2,152,658 specimens collected in 2006-2007 and 2008-2009 were tested for HIV-1 infection. We found that the overall prevalence of infections elevated from 0.064% in 2006-2007 to 0.074% in 2008-2009 (P = 0.003). A high frequency of HIV-1 infections was consistently related to unprotected heterosexual transmissions compared with other risk groups such as intravenous drug users. Critically, the prevalence rate had significantly increased in recent years among general populations such as voluntary blood donors (P < 0.001), recipients of blood transfusion (P < 0.001) and people during presurgery screening (P < 0.001). Besides CRF01-AE as the major circulating subtype (61/86, 70.9%), 25 non-CRF01-AE strains were found contributing to increased HIV-1 genetic diversity including C/CRF07-BC/CRF08-BC (5.8%), B/B' (15.1%), unique recombinant forms (8.1%), and some minor drug-resistant variants. Conclusions: Increased prevalence of HIV-1 infections among general populations likely accounts for the rising epidemic in recent years in Fujian. The epidemic was no longer dictated by CRF01-AE but rather by multisubtype viruses. Our findings call for an enhanced surveillance system and have implications to strategic prevention programs among general populations. © 2012 Lippincott Williams & Wilkins.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Acquired Immune Deficiency Syndromes, 2012, v. 60 n. 3, p. 328-335 [How to Cite?]
DOI: http://dx.doi.org/10.1097/QAI.0b013e31824f19f5
 
dc.identifier.doihttp://dx.doi.org/10.1097/QAI.0b013e31824f19f5
 
dc.identifier.epage335
 
dc.identifier.hkuros200529
 
dc.identifier.hkuros206327
 
dc.identifier.hkuros225305
 
dc.identifier.isiWOS:000305804400026
Funding AgencyGrant Number
China governmental agency
HKU-UDF
LSK Faculty of Medicine
HKU201007176151
China's Major Project of the National Science and Technology2012ZX10001-009
Funding Information:

The authors are indebted to all study participants. The authors thank all health workers at Fujian 220 HIV-1 testing sites for initial screening tests. The authors thank China governmental agency for financial supports to Fujian and Fuzhou Center for Disease Control and Preventions.

 
dc.identifier.issn1525-4135
2013 Impact Factor: 4.394
 
dc.identifier.issue3
 
dc.identifier.pmid22343181
 
dc.identifier.scopuseid_2-s2.0-84864321588
 
dc.identifier.spage328
 
dc.identifier.urihttp://hdl.handle.net/10722/152764
 
dc.identifier.volume60
 
dc.languageeng
 
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jaids.com
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Acquired Immune Deficiency Syndromes
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshChina - epidemiology
 
dc.subject.meshDrug Resistance, Viral - genetics
 
dc.subject.meshEpidemics
 
dc.subject.meshFemale
 
dc.subject.meshGenes, gag
 
dc.subject.meshGenes, pol
 
dc.subject.meshHIV Infections - complications - epidemiology - virology
 
dc.subject.meshHIV-1 - classification - drug effects - genetics
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshMutation
 
dc.subject.meshPhylogeny
 
dc.subject.meshPregnancy
 
dc.subject.meshPregnancy Complications, Infectious - epidemiology
 
dc.subject.meshPrevalence
 
dc.subject.meshRecombination, Genetic
 
dc.subject.meshYoung Adult
 
dc.titleRising epidemic of HIV-1 infections among general populations in Fujian, China
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Fujian Center for Disease Control and Prevention
  3. Fuzhou Center for Disease Control and Prevention
  4. Shenzhen People's Hospital