Article: Rising epidemic of HIV-1 infections among general populations in Fujian, China

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TitleRising epidemic of HIV-1 infections among general populations in Fujian, China
AuthorsYao, X1 3
Wang, H1
Yan, P2
Lu, Y3
Lin, H3
Chen, L2
Ng, J1
Lau, E
Liu, L1
Wu, J
Chen, Z
Issue Date2012
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jaids.com
CitationJournal Of Acquired Immune Deficiency Syndromes, 2012, v. 60 n. 3, p. 328-335 [How to Cite?]
DOI: http://dx.doi.org/10.1097/QAI.0b013e31824f19f5
AbstractBackground: HIV-1 infections have increased significantly with a doubled number of cases identified between 2006-2007 and 2008-2009 in Fujian, a southeastern province of China. No study has investigated the cause and the evolving epidemic there. Methods: In a province-wide study of recently identified infections from 2006 to 2009, we sought to investigate the rising epidemic of HIV-1 infections among general populations and conducted a molecular epidemiology study to determine the new trends of HIV-1 evolution there. Results: About 915,830 and 2,152,658 specimens collected in 2006-2007 and 2008-2009 were tested for HIV-1 infection. We found that the overall prevalence of infections elevated from 0.064% in 2006-2007 to 0.074% in 2008-2009 (P = 0.003). A high frequency of HIV-1 infections was consistently related to unprotected heterosexual transmissions compared with other risk groups such as intravenous drug users. Critically, the prevalence rate had significantly increased in recent years among general populations such as voluntary blood donors (P < 0.001), recipients of blood transfusion (P < 0.001) and people during presurgery screening (P < 0.001). Besides CRF01-AE as the major circulating subtype (61/86, 70.9%), 25 non-CRF01-AE strains were found contributing to increased HIV-1 genetic diversity including C/CRF07-BC/CRF08-BC (5.8%), B/B' (15.1%), unique recombinant forms (8.1%), and some minor drug-resistant variants. Conclusions: Increased prevalence of HIV-1 infections among general populations likely accounts for the rising epidemic in recent years in Fujian. The epidemic was no longer dictated by CRF01-AE but rather by multisubtype viruses. Our findings call for an enhanced surveillance system and have implications to strategic prevention programs among general populations. © 2012 Lippincott Williams & Wilkins.
ISSN1525-4135
2011 Impact Factor: 4.425
2011 SCImago Journal Rankings: 0.483
DOIhttp://dx.doi.org/10.1097/QAI.0b013e31824f19f5
ISI Accession Number IDWOS:000305804400026
Funding AgencyGrant Number
China governmental agency
HKU-UDF
LSK Faculty of Medicine
HKU201007176151
China's Major Project of the National Science and Technology2012ZX10001-009
Funding Information:

The authors are indebted to all study participants. The authors thank all health workers at Fujian 220 HIV-1 testing sites for initial screening tests. The authors thank China governmental agency for financial supports to Fujian and Fuzhou Center for Disease Control and Preventions.

ReferencesReferences in Scopus
GrantsInvestigation of HIV-1 new outbreaks in Fujian, China
DC Field
Value
dc.contributor.authorYao, X
dc.contributor.authorWang, H
dc.contributor.authorYan, P
dc.contributor.authorLu, Y
dc.contributor.authorLin, H
dc.contributor.authorChen, L
dc.contributor.authorNg, J
dc.contributor.authorLau, E
dc.contributor.authorLiu, L
dc.contributor.authorWu, J
dc.contributor.authorChen, Z
dc.date.accessioned2012-07-16T09:47:56Z
dc.date.available2012-07-16T09:47:56Z
dc.date.issued2012
dc.description.abstractBackground: HIV-1 infections have increased significantly with a doubled number of cases identified between 2006-2007 and 2008-2009 in Fujian, a southeastern province of China. No study has investigated the cause and the evolving epidemic there. Methods: In a province-wide study of recently identified infections from 2006 to 2009, we sought to investigate the rising epidemic of HIV-1 infections among general populations and conducted a molecular epidemiology study to determine the new trends of HIV-1 evolution there. Results: About 915,830 and 2,152,658 specimens collected in 2006-2007 and 2008-2009 were tested for HIV-1 infection. We found that the overall prevalence of infections elevated from 0.064% in 2006-2007 to 0.074% in 2008-2009 (P = 0.003). A high frequency of HIV-1 infections was consistently related to unprotected heterosexual transmissions compared with other risk groups such as intravenous drug users. Critically, the prevalence rate had significantly increased in recent years among general populations such as voluntary blood donors (P < 0.001), recipients of blood transfusion (P < 0.001) and people during presurgery screening (P < 0.001). Besides CRF01-AE as the major circulating subtype (61/86, 70.9%), 25 non-CRF01-AE strains were found contributing to increased HIV-1 genetic diversity including C/CRF07-BC/CRF08-BC (5.8%), B/B' (15.1%), unique recombinant forms (8.1%), and some minor drug-resistant variants. Conclusions: Increased prevalence of HIV-1 infections among general populations likely accounts for the rising epidemic in recent years in Fujian. The epidemic was no longer dictated by CRF01-AE but rather by multisubtype viruses. Our findings call for an enhanced surveillance system and have implications to strategic prevention programs among general populations. © 2012 Lippincott Williams & Wilkins.
dc.description.grantInvestigation of HIV-1 new outbreaks in Fujian, China
dc.description.grantcode104092
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Acquired Immune Deficiency Syndromes, 2012, v. 60 n. 3, p. 328-335 [How to Cite?]
DOI: http://dx.doi.org/10.1097/QAI.0b013e31824f19f5
dc.identifier.doihttp://dx.doi.org/10.1097/QAI.0b013e31824f19f5
dc.identifier.epage335
dc.identifier.hkuros200529
dc.identifier.hkuros206327
dc.identifier.isiWOS:000305804400026
Funding AgencyGrant Number
China governmental agency
HKU-UDF
LSK Faculty of Medicine
HKU201007176151
China's Major Project of the National Science and Technology2012ZX10001-009
Funding Information:

The authors are indebted to all study participants. The authors thank all health workers at Fujian 220 HIV-1 testing sites for initial screening tests. The authors thank China governmental agency for financial supports to Fujian and Fuzhou Center for Disease Control and Preventions.

dc.identifier.issn1525-4135
2011 Impact Factor: 4.425
2011 SCImago Journal Rankings: 0.483
dc.identifier.issue3
dc.identifier.pmid22343181
dc.identifier.scopuseid_2-s2.0-84864321588
dc.identifier.spage328
dc.identifier.urihttp://hdl.handle.net/10722/152764
dc.identifier.volume60
dc.languageeng
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jaids.com
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Acquired Immune Deficiency Syndromes
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshChina - epidemiology
dc.subject.meshDrug Resistance, Viral - genetics
dc.subject.meshEpidemics
dc.subject.meshFemale
dc.subject.meshGenes, gag
dc.subject.meshGenes, pol
dc.subject.meshHIV Infections - complications - epidemiology - virology
dc.subject.meshHIV-1 - classification - drug effects - genetics
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMutation
dc.subject.meshPhylogeny
dc.subject.meshPregnancy
dc.subject.meshPregnancy Complications, Infectious - epidemiology
dc.subject.meshPrevalence
dc.subject.meshRecombination, Genetic
dc.subject.meshYoung Adult
dc.titleRising epidemic of HIV-1 infections among general populations in Fujian, China
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Fujian Center for Disease Control and Prevention
  3. Fuzhou Center for Disease Control and Prevention
  4. Shenzhen People's Hospital