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Article: Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese
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TitleAssociation between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese
 
AuthorsCheung, BMY1 2
Ong, KL1
Cheung, RV1
Wong, LYF1
Wat, NMS1
Tam, S3
Leung, GM1
Cheng, CH1
Woo, J5
Janus, ED4
Lau, CP1
Hing Lam, T1
Lam, KSL1
 
KeywordsAlkaline phosphatase
C-reactive protein
Inflammation
Liver
 
Issue Date2008
 
PublisherWalter de Gruyter GmbH & Co KG. The Journal's web site is located at http://www.degruyter.de/journals/cclm
 
CitationClinical Chemistry And Laboratory Medicine, 2008, v. 46 n. 4, p. 523-527 [How to Cite?]
DOI: http://dx.doi.org/10.1515/CCLM.2008.111
 
AbstractBackground: Alkaline phosphatase (ALP) is a biomarker for hepatobiliary and skeletal diseases. It is also raised in sepsis. In atherosclerotic plaques, ALP is expressed. Similar to C-reactive protein (CRP), it may be another marker of systemic inflammation. Therefore, we investigated their association in a Hong Kong Chinese population. Methods: Plasma ALP and CRP were measured in 205 subjects (110 men, 95 women; age 55.2±11.6 years) in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 cohort. Results: The blood levels of ALP and CRP were significantly correlated (r=0.30, p<0.001), which was due to a significant correlation in women (r=0.43, p<0.001). In a multivariate model, CRP level was related to ALP (β=0.18, p=0.008). After adjusting for confounding factors and other liver enzymes, the relationship between ALP and CRP remained significant in women (β=0.28, p=0.019), but in men, ALP was not an independent determinant of CRP levels. Conclusions: ALP may be another marker of systemic inflammation, especially in women. Whether it provides clinical information additional to CRP requires further study. © 2008 by Walter de Gruyter.
 
ISSN1434-6621
2013 Impact Factor: 2.955
 
DOIhttp://dx.doi.org/10.1515/CCLM.2008.111
 
ISI Accession Number IDWOS:000255522400019
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCheung, BMY
 
dc.contributor.authorOng, KL
 
dc.contributor.authorCheung, RV
 
dc.contributor.authorWong, LYF
 
dc.contributor.authorWat, NMS
 
dc.contributor.authorTam, S
 
dc.contributor.authorLeung, GM
 
dc.contributor.authorCheng, CH
 
dc.contributor.authorWoo, J
 
dc.contributor.authorJanus, ED
 
dc.contributor.authorLau, CP
 
dc.contributor.authorHing Lam, T
 
dc.contributor.authorLam, KSL
 
dc.date.accessioned2012-06-26T06:25:57Z
 
dc.date.available2012-06-26T06:25:57Z
 
dc.date.issued2008
 
dc.description.abstractBackground: Alkaline phosphatase (ALP) is a biomarker for hepatobiliary and skeletal diseases. It is also raised in sepsis. In atherosclerotic plaques, ALP is expressed. Similar to C-reactive protein (CRP), it may be another marker of systemic inflammation. Therefore, we investigated their association in a Hong Kong Chinese population. Methods: Plasma ALP and CRP were measured in 205 subjects (110 men, 95 women; age 55.2±11.6 years) in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 cohort. Results: The blood levels of ALP and CRP were significantly correlated (r=0.30, p<0.001), which was due to a significant correlation in women (r=0.43, p<0.001). In a multivariate model, CRP level was related to ALP (β=0.18, p=0.008). After adjusting for confounding factors and other liver enzymes, the relationship between ALP and CRP remained significant in women (β=0.28, p=0.019), but in men, ALP was not an independent determinant of CRP levels. Conclusions: ALP may be another marker of systemic inflammation, especially in women. Whether it provides clinical information additional to CRP requires further study. © 2008 by Walter de Gruyter.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationClinical Chemistry And Laboratory Medicine, 2008, v. 46 n. 4, p. 523-527 [How to Cite?]
DOI: http://dx.doi.org/10.1515/CCLM.2008.111
 
dc.identifier.doihttp://dx.doi.org/10.1515/CCLM.2008.111
 
dc.identifier.epage527
 
dc.identifier.isiWOS:000255522400019
 
dc.identifier.issn1434-6621
2013 Impact Factor: 2.955
 
dc.identifier.issue4
 
dc.identifier.pmid18605934
 
dc.identifier.scopuseid_2-s2.0-44949173227
 
dc.identifier.spage523
 
dc.identifier.urihttp://hdl.handle.net/10722/151651
 
dc.identifier.volume46
 
dc.languageeng
 
dc.publisherWalter de Gruyter GmbH & Co KG. The Journal's web site is located at http://www.degruyter.de/journals/cclm
 
dc.publisher.placeGermany
 
dc.relation.ispartofClinical Chemistry and Laboratory Medicine
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAged
 
dc.subject.meshAlkaline Phosphatase - Blood
 
dc.subject.meshC-Reactive Protein - Biosynthesis
 
dc.subject.meshCardiovascular Diseases - Blood - Diagnosis - Ethnology
 
dc.subject.meshFemale
 
dc.subject.meshHong Kong
 
dc.subject.meshHumans
 
dc.subject.meshInflammation
 
dc.subject.meshLiver - Pathology
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshMultivariate Analysis
 
dc.subject.meshReference Values
 
dc.subject.meshRisk Factors
 
dc.subject.meshSex Factors
 
dc.subjectAlkaline phosphatase
 
dc.subjectC-reactive protein
 
dc.subjectInflammation
 
dc.subjectLiver
 
dc.titleAssociation between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese
 
dc.typeArticle
 
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<contributor.author>Ong, KL</contributor.author>
<contributor.author>Cheung, RV</contributor.author>
<contributor.author>Wong, LYF</contributor.author>
<contributor.author>Wat, NMS</contributor.author>
<contributor.author>Tam, S</contributor.author>
<contributor.author>Leung, GM</contributor.author>
<contributor.author>Cheng, CH</contributor.author>
<contributor.author>Woo, J</contributor.author>
<contributor.author>Janus, ED</contributor.author>
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<description.abstract>Background: Alkaline phosphatase (ALP) is a biomarker for hepatobiliary and skeletal diseases. It is also raised in sepsis. In atherosclerotic plaques, ALP is expressed. Similar to C-reactive protein (CRP), it may be another marker of systemic inflammation. Therefore, we investigated their association in a Hong Kong Chinese population. Methods: Plasma ALP and CRP were measured in 205 subjects (110 men, 95 women; age 55.2&#177;11.6 years) in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 cohort. Results: The blood levels of ALP and CRP were significantly correlated (r=0.30, p&lt;0.001), which was due to a significant correlation in women (r=0.43, p&lt;0.001). In a multivariate model, CRP level was related to ALP (&#946;=0.18, p=0.008). After adjusting for confounding factors and other liver enzymes, the relationship between ALP and CRP remained significant in women (&#946;=0.28, p=0.019), but in men, ALP was not an independent determinant of CRP levels. Conclusions: ALP may be another marker of systemic inflammation, especially in women. Whether it provides clinical information additional to CRP requires further study. &#169; 2008 by Walter de Gruyter.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. University of Birmingham
  3. Queen Mary Hospital Hong Kong
  4. University of Melbourne
  5. Chinese University of Hong Kong