Article: Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese

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TitleAssociation between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese
AuthorsCheung, BMY1 2
Ong, KL1
Cheung, RV1
Wong, LYF1
Wat, NMS1
Tam, S3
Leung, GM1
Cheng, CH1
Woo, J5
Janus, ED4
Lau, CP1
Hing Lam, T1
Lam, KSL1
KeywordsAlkaline phosphatase
C-reactive protein
Inflammation
Liver
Issue Date2008
PublisherWalter de Gruyter GmbH & Co KG. The Journal's web site is located at http://www.degruyter.de/journals/cclm
CitationClinical Chemistry And Laboratory Medicine, 2008, v. 46 n. 4, p. 523-527 [How to Cite?]
DOI: http://dx.doi.org/10.1515/CCLM.2008.111
AbstractBackground: Alkaline phosphatase (ALP) is a biomarker for hepatobiliary and skeletal diseases. It is also raised in sepsis. In atherosclerotic plaques, ALP is expressed. Similar to C-reactive protein (CRP), it may be another marker of systemic inflammation. Therefore, we investigated their association in a Hong Kong Chinese population. Methods: Plasma ALP and CRP were measured in 205 subjects (110 men, 95 women; age 55.2±11.6 years) in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 cohort. Results: The blood levels of ALP and CRP were significantly correlated (r=0.30, p<0.001), which was due to a significant correlation in women (r=0.43, p<0.001). In a multivariate model, CRP level was related to ALP (β=0.18, p=0.008). After adjusting for confounding factors and other liver enzymes, the relationship between ALP and CRP remained significant in women (β=0.28, p=0.019), but in men, ALP was not an independent determinant of CRP levels. Conclusions: ALP may be another marker of systemic inflammation, especially in women. Whether it provides clinical information additional to CRP requires further study. © 2008 by Walter de Gruyter.
ISSN1434-6621
2011 Impact Factor: 2.15
2011 SCImago Journal Rankings: 0.147
DOIhttp://dx.doi.org/10.1515/CCLM.2008.111
ISI Accession Number IDWOS:000255522400019
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorCheung, BMY
dc.contributor.authorOng, KL
dc.contributor.authorCheung, RV
dc.contributor.authorWong, LYF
dc.contributor.authorWat, NMS
dc.contributor.authorTam, S
dc.contributor.authorLeung, GM
dc.contributor.authorCheng, CH
dc.contributor.authorWoo, J
dc.contributor.authorJanus, ED
dc.contributor.authorLau, CP
dc.contributor.authorHing Lam, T
dc.contributor.authorLam, KSL
dc.date.accessioned2012-06-26T06:25:57Z
dc.date.available2012-06-26T06:25:57Z
dc.date.issued2008
dc.description.abstractBackground: Alkaline phosphatase (ALP) is a biomarker for hepatobiliary and skeletal diseases. It is also raised in sepsis. In atherosclerotic plaques, ALP is expressed. Similar to C-reactive protein (CRP), it may be another marker of systemic inflammation. Therefore, we investigated their association in a Hong Kong Chinese population. Methods: Plasma ALP and CRP were measured in 205 subjects (110 men, 95 women; age 55.2±11.6 years) in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 cohort. Results: The blood levels of ALP and CRP were significantly correlated (r=0.30, p<0.001), which was due to a significant correlation in women (r=0.43, p<0.001). In a multivariate model, CRP level was related to ALP (β=0.18, p=0.008). After adjusting for confounding factors and other liver enzymes, the relationship between ALP and CRP remained significant in women (β=0.28, p=0.019), but in men, ALP was not an independent determinant of CRP levels. Conclusions: ALP may be another marker of systemic inflammation, especially in women. Whether it provides clinical information additional to CRP requires further study. © 2008 by Walter de Gruyter.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationClinical Chemistry And Laboratory Medicine, 2008, v. 46 n. 4, p. 523-527 [How to Cite?]
DOI: http://dx.doi.org/10.1515/CCLM.2008.111
dc.identifier.doihttp://dx.doi.org/10.1515/CCLM.2008.111
dc.identifier.epage527
dc.identifier.isiWOS:000255522400019
dc.identifier.issn1434-6621
2011 Impact Factor: 2.15
2011 SCImago Journal Rankings: 0.147
dc.identifier.issue4
dc.identifier.pmid18605934
dc.identifier.scopuseid_2-s2.0-44949173227
dc.identifier.spage523
dc.identifier.urihttp://hdl.handle.net/10722/151651
dc.identifier.volume46
dc.languageeng
dc.publisherWalter de Gruyter GmbH & Co KG. The Journal's web site is located at http://www.degruyter.de/journals/cclm
dc.publisher.placeGermany
dc.relation.ispartofClinical Chemistry and Laboratory Medicine
dc.relation.referencesReferences in Scopus
dc.subject.meshAged
dc.subject.meshAlkaline Phosphatase - Blood
dc.subject.meshC-Reactive Protein - Biosynthesis
dc.subject.meshCardiovascular Diseases - Blood - Diagnosis - Ethnology
dc.subject.meshFemale
dc.subject.meshHong Kong
dc.subject.meshHumans
dc.subject.meshInflammation
dc.subject.meshLiver - Pathology
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMultivariate Analysis
dc.subject.meshReference Values
dc.subject.meshRisk Factors
dc.subject.meshSex Factors
dc.subjectAlkaline phosphatase
dc.subjectC-reactive protein
dc.subjectInflammation
dc.subjectLiver
dc.titleAssociation between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. University of Birmingham
  3. Queen Mary Hospital Hong Kong
  4. University of Melbourne
  5. Chinese University of Hong Kong