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Article: Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese

TitleAssociation between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese
Authors
KeywordsAlkaline phosphatase
C-reactive protein
Inflammation
Liver
Issue Date2008
PublisherWalter de Gruyter GmbH & Co KG. The Journal's web site is located at http://www.degruyter.de/journals/cclm
Citation
Clinical Chemistry And Laboratory Medicine, 2008, v. 46 n. 4, p. 523-527 How to Cite?
AbstractBackground: Alkaline phosphatase (ALP) is a biomarker for hepatobiliary and skeletal diseases. It is also raised in sepsis. In atherosclerotic plaques, ALP is expressed. Similar to C-reactive protein (CRP), it may be another marker of systemic inflammation. Therefore, we investigated their association in a Hong Kong Chinese population. Methods: Plasma ALP and CRP were measured in 205 subjects (110 men, 95 women; age 55.2±11.6 years) in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 cohort. Results: The blood levels of ALP and CRP were significantly correlated (r=0.30, p<0.001), which was due to a significant correlation in women (r=0.43, p<0.001). In a multivariate model, CRP level was related to ALP (β=0.18, p=0.008). After adjusting for confounding factors and other liver enzymes, the relationship between ALP and CRP remained significant in women (β=0.28, p=0.019), but in men, ALP was not an independent determinant of CRP levels. Conclusions: ALP may be another marker of systemic inflammation, especially in women. Whether it provides clinical information additional to CRP requires further study. © 2008 by Walter de Gruyter.
Persistent Identifierhttp://hdl.handle.net/10722/151651
ISSN
2015 Impact Factor: 3.017
2015 SCImago Journal Rankings: 0.873
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorOng, KLen_HK
dc.contributor.authorCheung, RVen_HK
dc.contributor.authorWong, LYFen_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorLeung, GMen_HK
dc.contributor.authorCheng, CHen_HK
dc.contributor.authorWoo, Jen_HK
dc.contributor.authorJanus, EDen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorHing Lam, Ten_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2012-06-26T06:25:57Z-
dc.date.available2012-06-26T06:25:57Z-
dc.date.issued2008en_HK
dc.identifier.citationClinical Chemistry And Laboratory Medicine, 2008, v. 46 n. 4, p. 523-527en_HK
dc.identifier.issn1434-6621en_HK
dc.identifier.urihttp://hdl.handle.net/10722/151651-
dc.description.abstractBackground: Alkaline phosphatase (ALP) is a biomarker for hepatobiliary and skeletal diseases. It is also raised in sepsis. In atherosclerotic plaques, ALP is expressed. Similar to C-reactive protein (CRP), it may be another marker of systemic inflammation. Therefore, we investigated their association in a Hong Kong Chinese population. Methods: Plasma ALP and CRP were measured in 205 subjects (110 men, 95 women; age 55.2±11.6 years) in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 cohort. Results: The blood levels of ALP and CRP were significantly correlated (r=0.30, p<0.001), which was due to a significant correlation in women (r=0.43, p<0.001). In a multivariate model, CRP level was related to ALP (β=0.18, p=0.008). After adjusting for confounding factors and other liver enzymes, the relationship between ALP and CRP remained significant in women (β=0.28, p=0.019), but in men, ALP was not an independent determinant of CRP levels. Conclusions: ALP may be another marker of systemic inflammation, especially in women. Whether it provides clinical information additional to CRP requires further study. © 2008 by Walter de Gruyter.en_HK
dc.languageengen_US
dc.publisherWalter de Gruyter GmbH & Co KG. The Journal's web site is located at http://www.degruyter.de/journals/cclmen_HK
dc.relation.ispartofClinical Chemistry and Laboratory Medicineen_HK
dc.subjectAlkaline phosphataseen_HK
dc.subjectC-reactive proteinen_HK
dc.subjectInflammationen_HK
dc.subjectLiveren_HK
dc.subject.meshAgeden_US
dc.subject.meshAlkaline Phosphatase - Blooden_US
dc.subject.meshC-Reactive Protein - Biosynthesisen_US
dc.subject.meshCardiovascular Diseases - Blood - Diagnosis - Ethnologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshInflammationen_US
dc.subject.meshLiver - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSex Factorsen_US
dc.titleAssociation between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chineseen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.emailLeung, GM:gmleung@hku.hken_HK
dc.identifier.emailHing Lam, T:hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityLeung, GM=rp00460en_HK
dc.identifier.authorityHing Lam, T=rp00326en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1515/CCLM.2008.111en_HK
dc.identifier.pmid18605934-
dc.identifier.scopuseid_2-s2.0-44949173227en_HK
dc.identifier.hkuros153420-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-44949173227&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume46en_HK
dc.identifier.issue4en_HK
dc.identifier.spage523en_HK
dc.identifier.epage527en_HK
dc.identifier.isiWOS:000255522400019-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridCheung, RV=24342924500en_HK
dc.identifier.scopusauthoridWong, LYF=24476809800en_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridLeung, GM=7007159841en_HK
dc.identifier.scopusauthoridCheng, CH=37053188100en_HK
dc.identifier.scopusauthoridWoo, J=36040369400en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridHing Lam, T=7202522876en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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