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Article: Analysis of a three-way race between tumor growth, a replication-competent virus and an immune response

TitleAnalysis of a three-way race between tumor growth, a replication-competent virus and an immune response
Authors
Issue Date2004
PublisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/sgw/cda/frontpage/0,11855,4-40604-70-85686626-0,00.html?changeHeader=true
Citation
Bulletin Of Mathematical Biology, 2004, v. 66 n. 4, p. 605-625 How to Cite?
AbstractReplication-competent viruses have the potential to overcome the delivery barrier in tumors that has plagued traditional gene-therapy approaches to cancer treatment. However, recent clinical data suggests that a cytokine-based immune response against the virus-infected tumor cells may severely limit the efficacy of the replication-competent approach. This paper generalizes our earlier spatial model to incorporate an immune response against the infected tumor cells. An approximate but accurate condition is derived for the virus - if uniformly injected throughout the tumor - to eradicate the tumor in the presence of the immune response. To validate the model using clinical data describing the temporal interaction of tumor necrosis factor and free virus in the plasma, we needed the immune response to be time-delayed and experience either saturated stimulation or second-order clearance. The resulting estimates of some unknown parameters provide some implications for the delivery of treatment. © 2003 Society for Mathematical Biology. Published by Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/151620
ISSN
2015 Impact Factor: 1.326
2015 SCImago Journal Rankings: 0.774
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, JTen_US
dc.contributor.authorKirn, DHen_US
dc.contributor.authorWein, LMen_US
dc.date.accessioned2012-06-26T06:25:35Z-
dc.date.available2012-06-26T06:25:35Z-
dc.date.issued2004en_US
dc.identifier.citationBulletin Of Mathematical Biology, 2004, v. 66 n. 4, p. 605-625en_US
dc.identifier.issn0092-8240en_US
dc.identifier.urihttp://hdl.handle.net/10722/151620-
dc.description.abstractReplication-competent viruses have the potential to overcome the delivery barrier in tumors that has plagued traditional gene-therapy approaches to cancer treatment. However, recent clinical data suggests that a cytokine-based immune response against the virus-infected tumor cells may severely limit the efficacy of the replication-competent approach. This paper generalizes our earlier spatial model to incorporate an immune response against the infected tumor cells. An approximate but accurate condition is derived for the virus - if uniformly injected throughout the tumor - to eradicate the tumor in the presence of the immune response. To validate the model using clinical data describing the temporal interaction of tumor necrosis factor and free virus in the plasma, we needed the immune response to be time-delayed and experience either saturated stimulation or second-order clearance. The resulting estimates of some unknown parameters provide some implications for the delivery of treatment. © 2003 Society for Mathematical Biology. Published by Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/sgw/cda/frontpage/0,11855,4-40604-70-85686626-0,00.html?changeHeader=trueen_US
dc.relation.ispartofBulletin of Mathematical Biologyen_US
dc.subject.meshAdenoviridae - Physiologyen_US
dc.subject.meshAdenovirus Infections, Human - Complications - Immunology - Virologyen_US
dc.subject.meshCell Growth Processes - Immunologyen_US
dc.subject.meshHead And Neck Neoplasms - Complications - Immunology - Pathology - Virologyen_US
dc.subject.meshHumansen_US
dc.subject.meshModels, Immunologicalen_US
dc.subject.meshVirus Replicationen_US
dc.titleAnalysis of a three-way race between tumor growth, a replication-competent virus and an immune responseen_US
dc.typeArticleen_US
dc.identifier.emailWu, JT:joewu@hkucc.hku.hken_US
dc.identifier.authorityWu, JT=rp00517en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.bulm.2003.08.016en_US
dc.identifier.pmid15210309-
dc.identifier.scopuseid_2-s2.0-3042684543en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3042684543&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume66en_US
dc.identifier.issue4en_US
dc.identifier.spage605en_US
dc.identifier.epage625en_US
dc.identifier.isiWOS:000222727400002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWu, JT=7409256423en_US
dc.identifier.scopusauthoridKirn, DH=7006444499en_US
dc.identifier.scopusauthoridWein, LM=35560766400en_US

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