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Article: β-thalassemia Major: Thin-Section CT Features and Correlation with Pulmonary Function and Iron Overload
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Titleβ-thalassemia Major: Thin-Section CT Features and Correlation with Pulmonary Function and Iron Overload
 
AuthorsKhong, PL1
Chan, GCF1
Lee, SL1
Au, WY1
Fong, DYT1
Tsang, KWT1
Ooi, GC1
 
KeywordsAnemia
Liver, MR
Lung, air trapping
Lung, CT
Lung, function
 
Issue Date2003
 
PublisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
 
CitationRadiology, 2003, v. 229 n. 2, p. 507-512 [How to Cite?]
DOI: http://dx.doi.org/10.1148/radiol.2292021805
 
AbstractPURPOSE: To describe and quantify thin-section computed tomographic (CT) features of the lung in patients with β-thalassemia major (β-TM) and determine the correlation between thin-section CT findings, pulmonary function test (PFT) results, and iron overload. MATERIALS AND METHODS: Forty-one patients with β-TM (mean age, 24.5 years) underwent thin-section CT (during full inspiration and expiration) and PFTs. Two radiologists in consensus recorded the presence of focal bronchial and parenchymal abnormalities and air trapping. A semiquantitative air trapping score (ATS) was used, and patients were separated into air trapping-negative (ATS between 0 and 3) and air trapping-positive (ATS > 3) groups for statistical analysis. Iron overload was estimated by calculating the ratio of the signal intensity (SI) of the liver to the SI of paraspinous muscle by using magnetic resonance imaging in 27 patients (66%). We performed multiple logistic regression analysis to study the influence of age, PFT findings, and SI ratio on the presence of air trapping at CT and multivariate regression analysis to study the simultaneous influence of the presence of air trapping on obstructive PFT indexes. RESULTS: Air trapping was the predominant thin-section CT finding and was seen in 10 (24%) of 41 patients. No patient had interstitial lung disease at CT, although 11 (27%) had a restrictive spirometric pattern. Simple logistic regression analysis revealed significant associations between ATS and forced expiratory volume in the first second (FEV1), FEV1/forced vital capacity (FVC), forced expiratory flow (FEF) in the midexpiratory phase (FEF25%-75%), FEF at 50% of the FVC (FEF50%), and FEF at 75% of the FVC (FEF75%) (P = .019, .030, .007, .034, and .021, respectively) but not between ATS and SI ratio. At multiple logistic regression analysis, only FEF25%-75% was significantly associated with ATS (P = .019, adjusted odds ratio = 0.86, R2 = 41.8%). Multivariate analysis revealed that ATS did not have a significant influence on lung function indexes (P = .104), although significant effects were found with FEV1, FEF25%-75%, FEF50%, and FEF75% when examined separately. CONCLUSION: Air trapping may be present at expiratory thin-section CT in patients with β-TM and is associated with reduced FEF 25%-75% values but not hepatic iron overload. © RSNA, 2003.
 
ISSN0033-8419
2013 Impact Factor: 6.214
 
DOIhttp://dx.doi.org/10.1148/radiol.2292021805
 
ISI Accession Number IDWOS:000186169700031
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorKhong, PL
 
dc.contributor.authorChan, GCF
 
dc.contributor.authorLee, SL
 
dc.contributor.authorAu, WY
 
dc.contributor.authorFong, DYT
 
dc.contributor.authorTsang, KWT
 
dc.contributor.authorOoi, GC
 
dc.date.accessioned2012-06-26T06:13:50Z
 
dc.date.available2012-06-26T06:13:50Z
 
dc.date.issued2003
 
dc.description.abstractPURPOSE: To describe and quantify thin-section computed tomographic (CT) features of the lung in patients with β-thalassemia major (β-TM) and determine the correlation between thin-section CT findings, pulmonary function test (PFT) results, and iron overload. MATERIALS AND METHODS: Forty-one patients with β-TM (mean age, 24.5 years) underwent thin-section CT (during full inspiration and expiration) and PFTs. Two radiologists in consensus recorded the presence of focal bronchial and parenchymal abnormalities and air trapping. A semiquantitative air trapping score (ATS) was used, and patients were separated into air trapping-negative (ATS between 0 and 3) and air trapping-positive (ATS > 3) groups for statistical analysis. Iron overload was estimated by calculating the ratio of the signal intensity (SI) of the liver to the SI of paraspinous muscle by using magnetic resonance imaging in 27 patients (66%). We performed multiple logistic regression analysis to study the influence of age, PFT findings, and SI ratio on the presence of air trapping at CT and multivariate regression analysis to study the simultaneous influence of the presence of air trapping on obstructive PFT indexes. RESULTS: Air trapping was the predominant thin-section CT finding and was seen in 10 (24%) of 41 patients. No patient had interstitial lung disease at CT, although 11 (27%) had a restrictive spirometric pattern. Simple logistic regression analysis revealed significant associations between ATS and forced expiratory volume in the first second (FEV1), FEV1/forced vital capacity (FVC), forced expiratory flow (FEF) in the midexpiratory phase (FEF25%-75%), FEF at 50% of the FVC (FEF50%), and FEF at 75% of the FVC (FEF75%) (P = .019, .030, .007, .034, and .021, respectively) but not between ATS and SI ratio. At multiple logistic regression analysis, only FEF25%-75% was significantly associated with ATS (P = .019, adjusted odds ratio = 0.86, R2 = 41.8%). Multivariate analysis revealed that ATS did not have a significant influence on lung function indexes (P = .104), although significant effects were found with FEV1, FEF25%-75%, FEF50%, and FEF75% when examined separately. CONCLUSION: Air trapping may be present at expiratory thin-section CT in patients with β-TM and is associated with reduced FEF 25%-75% values but not hepatic iron overload. © RSNA, 2003.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationRadiology, 2003, v. 229 n. 2, p. 507-512 [How to Cite?]
DOI: http://dx.doi.org/10.1148/radiol.2292021805
 
dc.identifier.doihttp://dx.doi.org/10.1148/radiol.2292021805
 
dc.identifier.epage512
 
dc.identifier.hkuros85137
 
dc.identifier.isiWOS:000186169700031
 
dc.identifier.issn0033-8419
2013 Impact Factor: 6.214
 
dc.identifier.issue2
 
dc.identifier.pmid14595151
 
dc.identifier.scopuseid_2-s2.0-0142178315
 
dc.identifier.spage507
 
dc.identifier.urihttp://hdl.handle.net/10722/150882
 
dc.identifier.volume229
 
dc.languageeng
 
dc.publisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofRadiology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdolescent
 
dc.subject.meshAdult
 
dc.subject.meshChild
 
dc.subject.meshFemale
 
dc.subject.meshForced Expiratory Flow Rates
 
dc.subject.meshForced Expiratory Volume
 
dc.subject.meshHumans
 
dc.subject.meshIron Overload - Complications - Diagnosis
 
dc.subject.meshLiver - Pathology
 
dc.subject.meshLiver Diseases - Complications - Diagnosis
 
dc.subject.meshLogistic Models
 
dc.subject.meshLung - Radiography
 
dc.subject.meshLung Diseases, Obstructive - Complications - Radiography
 
dc.subject.meshMagnetic Resonance Imaging
 
dc.subject.meshMale
 
dc.subject.meshMultivariate Analysis
 
dc.subject.meshPulmonary Ventilation
 
dc.subject.meshTomography, X-Ray Computed
 
dc.subject.meshVital Capacity
 
dc.subject.meshBeta-Thalassemia - Complications - Physiopathology - Radiography
 
dc.subjectAnemia
 
dc.subjectLiver, MR
 
dc.subjectLung, air trapping
 
dc.subjectLung, CT
 
dc.subjectLung, function
 
dc.titleβ-thalassemia Major: Thin-Section CT Features and Correlation with Pulmonary Function and Iron Overload
 
dc.typeArticle
 
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<contributor.author>Au, WY</contributor.author>
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<description.abstract>PURPOSE: To describe and quantify thin-section computed tomographic (CT) features of the lung in patients with &#946;-thalassemia major (&#946;-TM) and determine the correlation between thin-section CT findings, pulmonary function test (PFT) results, and iron overload. MATERIALS AND METHODS: Forty-one patients with &#946;-TM (mean age, 24.5 years) underwent thin-section CT (during full inspiration and expiration) and PFTs. Two radiologists in consensus recorded the presence of focal bronchial and parenchymal abnormalities and air trapping. A semiquantitative air trapping score (ATS) was used, and patients were separated into air trapping-negative (ATS between 0 and 3) and air trapping-positive (ATS &gt; 3) groups for statistical analysis. Iron overload was estimated by calculating the ratio of the signal intensity (SI) of the liver to the SI of paraspinous muscle by using magnetic resonance imaging in 27 patients (66%). We performed multiple logistic regression analysis to study the influence of age, PFT findings, and SI ratio on the presence of air trapping at CT and multivariate regression analysis to study the simultaneous influence of the presence of air trapping on obstructive PFT indexes. RESULTS: Air trapping was the predominant thin-section CT finding and was seen in 10 (24%) of 41 patients. No patient had interstitial lung disease at CT, although 11 (27%) had a restrictive spirometric pattern. Simple logistic regression analysis revealed significant associations between ATS and forced expiratory volume in the first second (FEV1), FEV1/forced vital capacity (FVC), forced expiratory flow (FEF) in the midexpiratory phase (FEF25%-75%), FEF at 50% of the FVC (FEF50%), and FEF at 75% of the FVC (FEF75%) (P = .019, .030, .007, .034, and .021, respectively) but not between ATS and SI ratio. At multiple logistic regression analysis, only FEF25%-75% was significantly associated with ATS (P = .019, adjusted odds ratio = 0.86, R2 = 41.8%). Multivariate analysis revealed that ATS did not have a significant influence on lung function indexes (P = .104), although significant effects were found with FEV1, FEF25%-75%, FEF50%, and FEF75% when examined separately. CONCLUSION: Air trapping may be present at expiratory thin-section CT in patients with &#946;-TM and is associated with reduced FEF 25%-75% values but not hepatic iron overload. &#169; RSNA, 2003.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong