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Article: β-thalassemia Major: Thin-Section CT Features and Correlation with Pulmonary Function and Iron Overload

Titleβ-thalassemia Major: Thin-Section CT Features and Correlation with Pulmonary Function and Iron Overload
Authors
KeywordsAnemia
Liver, MR
Lung, air trapping
Lung, CT
Lung, function
Issue Date2003
PublisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
Citation
Radiology, 2003, v. 229 n. 2, p. 507-512 How to Cite?
AbstractPURPOSE: To describe and quantify thin-section computed tomographic (CT) features of the lung in patients with β-thalassemia major (β-TM) and determine the correlation between thin-section CT findings, pulmonary function test (PFT) results, and iron overload. MATERIALS AND METHODS: Forty-one patients with β-TM (mean age, 24.5 years) underwent thin-section CT (during full inspiration and expiration) and PFTs. Two radiologists in consensus recorded the presence of focal bronchial and parenchymal abnormalities and air trapping. A semiquantitative air trapping score (ATS) was used, and patients were separated into air trapping-negative (ATS between 0 and 3) and air trapping-positive (ATS > 3) groups for statistical analysis. Iron overload was estimated by calculating the ratio of the signal intensity (SI) of the liver to the SI of paraspinous muscle by using magnetic resonance imaging in 27 patients (66%). We performed multiple logistic regression analysis to study the influence of age, PFT findings, and SI ratio on the presence of air trapping at CT and multivariate regression analysis to study the simultaneous influence of the presence of air trapping on obstructive PFT indexes. RESULTS: Air trapping was the predominant thin-section CT finding and was seen in 10 (24%) of 41 patients. No patient had interstitial lung disease at CT, although 11 (27%) had a restrictive spirometric pattern. Simple logistic regression analysis revealed significant associations between ATS and forced expiratory volume in the first second (FEV1), FEV1/forced vital capacity (FVC), forced expiratory flow (FEF) in the midexpiratory phase (FEF25%-75%), FEF at 50% of the FVC (FEF50%), and FEF at 75% of the FVC (FEF75%) (P = .019, .030, .007, .034, and .021, respectively) but not between ATS and SI ratio. At multiple logistic regression analysis, only FEF25%-75% was significantly associated with ATS (P = .019, adjusted odds ratio = 0.86, R2 = 41.8%). Multivariate analysis revealed that ATS did not have a significant influence on lung function indexes (P = .104), although significant effects were found with FEV1, FEF25%-75%, FEF50%, and FEF75% when examined separately. CONCLUSION: Air trapping may be present at expiratory thin-section CT in patients with β-TM and is associated with reduced FEF 25%-75% values but not hepatic iron overload. © RSNA, 2003.
Persistent Identifierhttp://hdl.handle.net/10722/150882
ISSN
2014 Impact Factor: 6.867
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorLee, SLen_HK
dc.contributor.authorAu, WYen_HK
dc.contributor.authorFong, DYTen_HK
dc.contributor.authorTsang, KWTen_HK
dc.contributor.authorOoi, GCen_HK
dc.date.accessioned2012-06-26T06:13:50Z-
dc.date.available2012-06-26T06:13:50Z-
dc.date.issued2003en_HK
dc.identifier.citationRadiology, 2003, v. 229 n. 2, p. 507-512en_HK
dc.identifier.issn0033-8419en_HK
dc.identifier.urihttp://hdl.handle.net/10722/150882-
dc.description.abstractPURPOSE: To describe and quantify thin-section computed tomographic (CT) features of the lung in patients with β-thalassemia major (β-TM) and determine the correlation between thin-section CT findings, pulmonary function test (PFT) results, and iron overload. MATERIALS AND METHODS: Forty-one patients with β-TM (mean age, 24.5 years) underwent thin-section CT (during full inspiration and expiration) and PFTs. Two radiologists in consensus recorded the presence of focal bronchial and parenchymal abnormalities and air trapping. A semiquantitative air trapping score (ATS) was used, and patients were separated into air trapping-negative (ATS between 0 and 3) and air trapping-positive (ATS > 3) groups for statistical analysis. Iron overload was estimated by calculating the ratio of the signal intensity (SI) of the liver to the SI of paraspinous muscle by using magnetic resonance imaging in 27 patients (66%). We performed multiple logistic regression analysis to study the influence of age, PFT findings, and SI ratio on the presence of air trapping at CT and multivariate regression analysis to study the simultaneous influence of the presence of air trapping on obstructive PFT indexes. RESULTS: Air trapping was the predominant thin-section CT finding and was seen in 10 (24%) of 41 patients. No patient had interstitial lung disease at CT, although 11 (27%) had a restrictive spirometric pattern. Simple logistic regression analysis revealed significant associations between ATS and forced expiratory volume in the first second (FEV1), FEV1/forced vital capacity (FVC), forced expiratory flow (FEF) in the midexpiratory phase (FEF25%-75%), FEF at 50% of the FVC (FEF50%), and FEF at 75% of the FVC (FEF75%) (P = .019, .030, .007, .034, and .021, respectively) but not between ATS and SI ratio. At multiple logistic regression analysis, only FEF25%-75% was significantly associated with ATS (P = .019, adjusted odds ratio = 0.86, R2 = 41.8%). Multivariate analysis revealed that ATS did not have a significant influence on lung function indexes (P = .104), although significant effects were found with FEV1, FEF25%-75%, FEF50%, and FEF75% when examined separately. CONCLUSION: Air trapping may be present at expiratory thin-section CT in patients with β-TM and is associated with reduced FEF 25%-75% values but not hepatic iron overload. © RSNA, 2003.en_HK
dc.languageengen_US
dc.publisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.orgen_HK
dc.relation.ispartofRadiologyen_HK
dc.subjectAnemiaen_HK
dc.subjectLiver, MRen_HK
dc.subjectLung, air trappingen_HK
dc.subjectLung, CTen_HK
dc.subjectLung, functionen_HK
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshForced Expiratory Flow Ratesen_US
dc.subject.meshForced Expiratory Volumeen_US
dc.subject.meshHumansen_US
dc.subject.meshIron Overload - Complications - Diagnosisen_US
dc.subject.meshLiver - Pathologyen_US
dc.subject.meshLiver Diseases - Complications - Diagnosisen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshLung - Radiographyen_US
dc.subject.meshLung Diseases, Obstructive - Complications - Radiographyen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshPulmonary Ventilationen_US
dc.subject.meshTomography, X-Ray Computeden_US
dc.subject.meshVital Capacityen_US
dc.subject.meshBeta-Thalassemia - Complications - Physiopathology - Radiographyen_US
dc.titleβ-thalassemia Major: Thin-Section CT Features and Correlation with Pulmonary Function and Iron Overloaden_HK
dc.typeArticleen_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.emailChan, GCF: gcfchan@hku.hken_HK
dc.identifier.emailFong, DYT: dytfong@hku.hken_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityFong, DYT=rp00253en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1148/radiol.2292021805en_HK
dc.identifier.pmid14595151en_HK
dc.identifier.scopuseid_2-s2.0-0142178315en_HK
dc.identifier.hkuros85137-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0142178315&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume229en_HK
dc.identifier.issue2en_HK
dc.identifier.spage507en_HK
dc.identifier.epage512en_HK
dc.identifier.isiWOS:000186169700031-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridLee, SL=8708381600en_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridFong, DYT=35261710300en_HK
dc.identifier.scopusauthoridTsang, KWT=7201555024en_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK

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