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Article: Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas

TitleExpression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas
Authors
Keywords3p21.3
BLU
Esophageal squamous cell carcinoma
Tumorigenicity
Issue Date2006
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2006, v. 234 n. 2, p. 184-192 How to Cite?
AbstractThe expression of six chromosome 3p21.3 candidate tumor suppressor genes (BLU, FUS2, HYAL2, NPRL2, RASSF1A, and SEMA3B) in esophageal squamous cell carcinoma (ESCC) has been investigated. Reduced expression of BLU was detected in some ESCC cell lines and tumor tissues and the difference was quantitated by real-time quantitative polymerase chain reaction. Methylation specific-PCR revealed the down-regulation of BLU by epigenetic inactivation. However, exogeneous expression of BLU did not functionally suppress tumorigenicity in nude mice. These results suggest that over-expression of BLU alone is not sufficient to inhibit tumorigenicity. Further studies on BLU interacting proteins are required to elucidate the possible role of BLU in the development of ESCC. © 2005 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/150800
ISSN
2015 Impact Factor: 5.992
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYi Lo, PHen_US
dc.contributor.authorChung Leung, ACen_US
dc.contributor.authorXiong, Wen_US
dc.contributor.authorLaw, Sen_US
dc.contributor.authorDuh, FMen_US
dc.contributor.authorLerman, MIen_US
dc.contributor.authorStanbridge, EJen_US
dc.contributor.authorLung, MLen_US
dc.date.accessioned2012-06-26T06:10:41Z-
dc.date.available2012-06-26T06:10:41Z-
dc.date.issued2006en_US
dc.identifier.citationCancer Letters, 2006, v. 234 n. 2, p. 184-192en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/150800-
dc.description.abstractThe expression of six chromosome 3p21.3 candidate tumor suppressor genes (BLU, FUS2, HYAL2, NPRL2, RASSF1A, and SEMA3B) in esophageal squamous cell carcinoma (ESCC) has been investigated. Reduced expression of BLU was detected in some ESCC cell lines and tumor tissues and the difference was quantitated by real-time quantitative polymerase chain reaction. Methylation specific-PCR revealed the down-regulation of BLU by epigenetic inactivation. However, exogeneous expression of BLU did not functionally suppress tumorigenicity in nude mice. These results suggest that over-expression of BLU alone is not sufficient to inhibit tumorigenicity. Further studies on BLU interacting proteins are required to elucidate the possible role of BLU in the development of ESCC. © 2005 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_US
dc.relation.ispartofCancer Lettersen_US
dc.rightsCancer Letters. Copyright © Elsevier Ireland Ltd.-
dc.subject3p21.3-
dc.subjectBLU-
dc.subjectEsophageal squamous cell carcinoma-
dc.subjectTumorigenicity-
dc.subject.meshAnimalsen_US
dc.subject.meshCarcinoma, Squamous Cell - Geneticsen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshChromosomes, Human, Pair 3en_US
dc.subject.meshDna Methylationen_US
dc.subject.meshDown-Regulationen_US
dc.subject.meshEsophageal Neoplasms - Geneticsen_US
dc.subject.meshGene Silencingen_US
dc.subject.meshGenes, Tumor Suppressor - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Nudeen_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_US
dc.subject.meshTumor Suppressor Proteinsen_US
dc.titleExpression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomasen_US
dc.typeArticleen_US
dc.identifier.emailLaw, S:slaw@hku.hken_US
dc.identifier.emailLung, ML:mlilung@hku.hken_US
dc.identifier.authorityLaw, S=rp00437en_US
dc.identifier.authorityLung, ML=rp00300en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.canlet.2005.03.036en_US
dc.identifier.pmid15885884-
dc.identifier.scopuseid_2-s2.0-33645014254en_US
dc.identifier.hkuros116095-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645014254&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume234en_US
dc.identifier.issue2en_US
dc.identifier.spage184en_US
dc.identifier.epage192en_US
dc.identifier.isiWOS:000236661400009-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridYi Lo, PH=12784354300en_US
dc.identifier.scopusauthoridChung Leung, AC=12784595600en_US
dc.identifier.scopusauthoridXiong, W=36898381800en_US
dc.identifier.scopusauthoridLaw, S=7202241293en_US
dc.identifier.scopusauthoridDuh, FM=7004146642en_US
dc.identifier.scopusauthoridLerman, MI=24356375900en_US
dc.identifier.scopusauthoridStanbridge, EJ=7103249410en_US
dc.identifier.scopusauthoridLung, ML=7006411788en_US

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