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Article: Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against β-amyloid peptide neurotoxicity

TitleNeuroprotective effects of anti-aging oriental medicine Lycium barbarum against β-amyloid peptide neurotoxicity
Authors
KeywordsArabinogalactan-protein
Beta-amyloid
Lycium barbarum
Neuroprotection
Issue Date2005
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/expgero
Citation
Experimental Gerontology, 2005, v. 40 n. 8-9, p. 716-727 How to Cite?
AbstractAs aged population dramatically increases in these decades, efforts should be made on the intervention for curing age-associated neurodegenerative diseases such as Alzheimer's disease (AD). Natural plant extracts of Lycium barbarum are well-known to exhibit anti-aging effects. We therefore hypothesized that they exhibit neuroprotective effects against toxins in aging-related neurodegenerative diseases. In this study, we aimed to investigate whether extracts from L. barbarum have neuroprotective effects against toxicity of fibrillar Aβ1-42 and Aβ25-35 fragments. Primary rat cortical neurons exposed to Aβ peptides resulted in apoptosis and necrosis. Pre-treatment with extract isolated from L. barbarum significantly reduced the release of lactate dehydrogenase (LDH). In addition, it attenuated Aβ peptide-activated caspases-3-like activity. The extract elicited a typical dose-dependent neuroprotective effect. Effective dosage of this extract was wider than that of a well-known western neuroprotective medicine lithium chloride (LiCl). We have further examined the underlying mechanisms of the neuroprotective effects. In agreement with other laboratories, Aβ peptides induce a rapid activation of c-Jun N-terminal kinase (JNK) by phosphorylation. Pre-treatment of aqueous extract markedly reduced the phosphorylation of JNK-1 (Thr183/Tyr185) and its substrates c-Jun-I (Ser 73) and c-Jun-II (Ser 63). Taken together, we have proved our hypothesis by showing neuroprotective effects of the extract from L. barbarum. Study on anti-aging herbal medicine like L. barbarum may open a new therapeutic window for the prevention of AD. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/149643
ISSN
2015 Impact Factor: 3.35
2015 SCImago Journal Rankings: 1.620
ISI Accession Number ID
Patent10722/45673
References

 

DC FieldValueLanguage
dc.contributor.authorYu, MSen_HK
dc.contributor.authorLeung, SKYen_HK
dc.contributor.authorLai, SWen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorZee, SYen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorYuen, WHen_HK
dc.contributor.authorChang, RCCen_HK
dc.date.accessioned2012-06-26T05:56:26Z-
dc.date.available2012-06-26T05:56:26Z-
dc.date.issued2005en_HK
dc.identifier.citationExperimental Gerontology, 2005, v. 40 n. 8-9, p. 716-727en_HK
dc.identifier.issn0531-5565en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149643-
dc.description.abstractAs aged population dramatically increases in these decades, efforts should be made on the intervention for curing age-associated neurodegenerative diseases such as Alzheimer's disease (AD). Natural plant extracts of Lycium barbarum are well-known to exhibit anti-aging effects. We therefore hypothesized that they exhibit neuroprotective effects against toxins in aging-related neurodegenerative diseases. In this study, we aimed to investigate whether extracts from L. barbarum have neuroprotective effects against toxicity of fibrillar Aβ1-42 and Aβ25-35 fragments. Primary rat cortical neurons exposed to Aβ peptides resulted in apoptosis and necrosis. Pre-treatment with extract isolated from L. barbarum significantly reduced the release of lactate dehydrogenase (LDH). In addition, it attenuated Aβ peptide-activated caspases-3-like activity. The extract elicited a typical dose-dependent neuroprotective effect. Effective dosage of this extract was wider than that of a well-known western neuroprotective medicine lithium chloride (LiCl). We have further examined the underlying mechanisms of the neuroprotective effects. In agreement with other laboratories, Aβ peptides induce a rapid activation of c-Jun N-terminal kinase (JNK) by phosphorylation. Pre-treatment of aqueous extract markedly reduced the phosphorylation of JNK-1 (Thr183/Tyr185) and its substrates c-Jun-I (Ser 73) and c-Jun-II (Ser 63). Taken together, we have proved our hypothesis by showing neuroprotective effects of the extract from L. barbarum. Study on anti-aging herbal medicine like L. barbarum may open a new therapeutic window for the prevention of AD. © 2005 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/expgeroen_HK
dc.relation.ispartofExperimental Gerontologyen_HK
dc.subjectArabinogalactan-proteinen_HK
dc.subjectBeta-amyloiden_HK
dc.subjectLycium barbarumen_HK
dc.subjectNeuroprotectionen_HK
dc.subject.meshAlzheimer Disease - Metabolism - Prevention & Controlen_US
dc.subject.meshAmyloid Beta-Peptides - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntimanic Agents - Pharmacologyen_US
dc.subject.meshApoptosis - Drug Effectsen_US
dc.subject.meshBlotting, Western - Methodsen_US
dc.subject.meshBrain - Drug Effects - Metabolismen_US
dc.subject.meshCaspase 3en_US
dc.subject.meshCaspases - Metabolismen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshDna Fragmentation - Drug Effectsen_US
dc.subject.meshDrugs, Chinese Herbal - Pharmacologyen_US
dc.subject.meshLithium Chloride - Pharmacologyen_US
dc.subject.meshLycium - Chemistryen_US
dc.subject.meshMedicine, East Asian Traditionalen_US
dc.subject.meshNeurons - Drug Effects - Metabolismen_US
dc.subject.meshNeuroprotective Agents - Pharmacologyen_US
dc.subject.meshPlant Extracts - Chemistryen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.titleNeuroprotective effects of anti-aging oriental medicine Lycium barbarum against β-amyloid peptide neurotoxicityen_HK
dc.typeArticleen_HK
dc.identifier.emailChe, CM:cmche@hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailChang, RCC:rccchang@hkucc.hku.hken_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.exger.2005.06.010en_HK
dc.identifier.pmid16139464-
dc.identifier.scopuseid_2-s2.0-24644510343en_HK
dc.identifier.hkuros105432-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-24644510343&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume40en_HK
dc.identifier.issue8-9en_HK
dc.identifier.spage716en_HK
dc.identifier.epage727en_HK
dc.identifier.isiWOS:000232330100011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYu, MS=35346047600en_HK
dc.identifier.scopusauthoridLeung, SKY=36546285500en_HK
dc.identifier.scopusauthoridLai, SW=8729823700en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.scopusauthoridZee, SY=7004001733en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridYuen, WH=7102761282en_HK
dc.identifier.scopusauthoridChang, RCC=7403713410en_HK
dc.relation.patent10722/45673-
dc.identifier.citeulike526023-

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