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Article: Single-nucleotide polymorphism of transient axonal glycoprotein-1 and its correlation with clinical features and prognosis in chronic inflammatory demyelinating polyneuropathy

TitleSingle-nucleotide polymorphism of transient axonal glycoprotein-1 and its correlation with clinical features and prognosis in chronic inflammatory demyelinating polyneuropathy
Authors
KeywordsCIDP
Prognosis
SNP
TAG-1
Issue Date2012
Citation
Journal Of The Peripheral Nervous System, 2012, v. 17 n. 1, p. 72-75 How to Cite?
AbstractThe single-nucleotide polymorphism (SNP) rs2275697 in the transient axonal glycoprotein-1 (TAG-1) gene was reported to be associated with responsiveness to intravenous immunoglobulin (IVIG) treatment in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). However, it is not known if this SNP is associated with long-term prognosis. We examined the case records of 32 Chinese CIDP patients. The overall response rate to IVIG, prednisolone, or plasmapheresis was 83%. After 5.4 years, 57% of patients were on maintenance immunotherapy. Patients with higher modified Rankin score and more prolonged distal motor latencies in the upper limbs on presentation had a higher risk (odds ratio [OR] 3.86, 95% confidence interval [CI] 1.23-12.11 and OR 1.04, 95% CI 1.01-1.07, respectively) of being on maintenance immunotherapy. Blood samples from 24 patients and 147 controls were examined for their genotypes of four non-synonymous SNPs (rs41264871, rs36074532, rs5611135, and rs2275697) in the coding region of TAG-1. The G allelic frequency of rs2275697 was similar between CIDP patients and controls (56% and 50%, respectively) and was not associated with treatment responsiveness, treatment dependence, disability, or mortality. © 2012 Peripheral Nerve Society.
Persistent Identifierhttp://hdl.handle.net/10722/149116
ISSN
2015 Impact Factor: 2.258
2015 SCImago Journal Rankings: 1.180
ISI Accession Number ID
Funding AgencyGrant Number
H. G. Leong Professorship in Neurology
University of Hong Kong
Funding Information:

This project was supported by the H. G. Leong Professorship in Neurology (SLH) and the Donation Fund for Neurology Research (SLH), University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorPang, SYYen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorMak, WWWen_HK
dc.contributor.authorKung, MHWen_HK
dc.contributor.authorLee, CNen_HK
dc.contributor.authorTsoi, THen_HK
dc.contributor.authorYip, EKKen_HK
dc.contributor.authorHo, SLen_HK
dc.date.accessioned2012-06-22T06:24:14Z-
dc.date.available2012-06-22T06:24:14Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of The Peripheral Nervous System, 2012, v. 17 n. 1, p. 72-75en_HK
dc.identifier.issn1085-9489en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149116-
dc.description.abstractThe single-nucleotide polymorphism (SNP) rs2275697 in the transient axonal glycoprotein-1 (TAG-1) gene was reported to be associated with responsiveness to intravenous immunoglobulin (IVIG) treatment in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). However, it is not known if this SNP is associated with long-term prognosis. We examined the case records of 32 Chinese CIDP patients. The overall response rate to IVIG, prednisolone, or plasmapheresis was 83%. After 5.4 years, 57% of patients were on maintenance immunotherapy. Patients with higher modified Rankin score and more prolonged distal motor latencies in the upper limbs on presentation had a higher risk (odds ratio [OR] 3.86, 95% confidence interval [CI] 1.23-12.11 and OR 1.04, 95% CI 1.01-1.07, respectively) of being on maintenance immunotherapy. Blood samples from 24 patients and 147 controls were examined for their genotypes of four non-synonymous SNPs (rs41264871, rs36074532, rs5611135, and rs2275697) in the coding region of TAG-1. The G allelic frequency of rs2275697 was similar between CIDP patients and controls (56% and 50%, respectively) and was not associated with treatment responsiveness, treatment dependence, disability, or mortality. © 2012 Peripheral Nerve Society.en_HK
dc.languageengen_US
dc.relation.ispartofJournal of the Peripheral Nervous Systemen_HK
dc.subjectCIDPen_HK
dc.subjectPrognosisen_HK
dc.subjectSNPen_HK
dc.subjectTAG-1en_HK
dc.titleSingle-nucleotide polymorphism of transient axonal glycoprotein-1 and its correlation with clinical features and prognosis in chronic inflammatory demyelinating polyneuropathyen_HK
dc.typeArticleen_HK
dc.identifier.emailHo, SL:slho@hku.hken_HK
dc.identifier.authorityHo, SL=rp00240en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1529-8027.2012.00380.xen_HK
dc.identifier.pmid22462668-
dc.identifier.scopuseid_2-s2.0-84859418554en_HK
dc.identifier.hkuros199854en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84859418554&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue1en_HK
dc.identifier.spage72en_HK
dc.identifier.epage75en_HK
dc.identifier.isiWOS:000302075000007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPang, SYY=55175013400en_HK
dc.identifier.scopusauthoridChan, KH=7406034963en_HK
dc.identifier.scopusauthoridMak, WWW=55175469300en_HK
dc.identifier.scopusauthoridKung, MHW=36336960300en_HK
dc.identifier.scopusauthoridLee, CN=16203206800en_HK
dc.identifier.scopusauthoridTsoi, TH=7003314299en_HK
dc.identifier.scopusauthoridYip, EKK=55175399300en_HK
dc.identifier.scopusauthoridHo, SL=25959633500en_HK

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