File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Cytokines and their roles in the pathogenesis of systemic lupus erythematosus: From basics to recent advances

TitleCytokines and their roles in the pathogenesis of systemic lupus erythematosus: From basics to recent advances
Authors
Issue Date2010
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html
Citation
Journal Of Biomedicine And Biotechnology, 2010, v. 2010, article no. 365083 How to Cite?
AbstractSystemic lupus erythematosus (SLE) is a complex auto-immune disorder which involves various facets of the immune system. In addition to autoantibody production and immune complex deposition, emerging evidences suggest that cytokines may act as key players in the immunopathogenesis of SLE. These cytokines assume a critical role in the differentiation, maturation and activation of cells and also participate in the local inflammatory processes that mediate tissue insults in SLE. Certain cytokines such as the IL-6, IL-10, IL-17, BLys, type I interferons (IFN) and tumor necrosis factor-α (TNF-α) are closely linked to pathogenesis of SLE. The delineation of the role played by these cytokines not only fosters our understanding of this disease but also provides a sound rationale for various therapeutic approaches. In this context, this review focuses on selected cytokines which exert significant effect in the pathogenesis of SLE and their possible clinical applications. © 2010 D. Y. H. Yap and K. N. Lai.
Persistent Identifierhttp://hdl.handle.net/10722/148920
ISSN
2014 Impact Factor: 3.169
ISI Accession Number ID
Funding AgencyGrant Number
L&T Charitable Foundation
House of INDOCAFE
Funding Information:

K. N. Lai is supported by the L&T Charitable Foundation and the House of INDOCAFE.

References

 

DC FieldValueLanguage
dc.contributor.authorYap, DYHen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2012-06-20T06:16:37Z-
dc.date.available2012-06-20T06:16:37Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Biomedicine And Biotechnology, 2010, v. 2010, article no. 365083en_HK
dc.identifier.issn1110-7243en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148920-
dc.description.abstractSystemic lupus erythematosus (SLE) is a complex auto-immune disorder which involves various facets of the immune system. In addition to autoantibody production and immune complex deposition, emerging evidences suggest that cytokines may act as key players in the immunopathogenesis of SLE. These cytokines assume a critical role in the differentiation, maturation and activation of cells and also participate in the local inflammatory processes that mediate tissue insults in SLE. Certain cytokines such as the IL-6, IL-10, IL-17, BLys, type I interferons (IFN) and tumor necrosis factor-α (TNF-α) are closely linked to pathogenesis of SLE. The delineation of the role played by these cytokines not only fosters our understanding of this disease but also provides a sound rationale for various therapeutic approaches. In this context, this review focuses on selected cytokines which exert significant effect in the pathogenesis of SLE and their possible clinical applications. © 2010 D. Y. H. Yap and K. N. Lai.en_HK
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.htmlen_HK
dc.relation.ispartofJournal of Biomedicine and Biotechnologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAnimalsen_US
dc.subject.meshCytokines - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLupus Erythematosus, Systemic - Physiopathologyen_US
dc.subject.meshMiceen_US
dc.subject.meshModels, Biologicalen_US
dc.titleCytokines and their roles in the pathogenesis of systemic lupus erythematosus: From basics to recent advancesen_HK
dc.typeArticleen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.emailYap, DYH: desmondy@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.identifier.authorityYap, DYH=rp01607en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1155/2010/365083en_HK
dc.identifier.pmid20467470-
dc.identifier.scopuseid_2-s2.0-77952540303en_HK
dc.identifier.hkuros180801-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952540303&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2010en_HK
dc.identifier.isiWOS:000278458600001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridYap, DYH=25958532000en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats