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Article: A functional single-nucleotide polymorphism in the promoter of the gene encoding interleukin 6 is associated with susceptibility to tuberculosis

TitleA functional single-nucleotide polymorphism in the promoter of the gene encoding interleukin 6 is associated with susceptibility to tuberculosis
Authors
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal of Infectious Diseases, 2012, v. 205 n. 11, p. 1697-1704 How to Cite?
Abstract
Background Genetic variation influences susceptibility or resistance to tuberculosis. Interleukin 6 (IL-6) contributes to protection against tuberculosis in mice. However, its role in regulating susceptibility or resistance to tuberculosis in humans is unclear. Methods Genotyping of polymorphisms in IL-6 and IL-6R (CD126) genes was performed in 2 independent cohorts, an experimental population (495 cases and 358 controls) and a validation population (1383 cases and 1149 controls). The associations of the variants with tuberculosis were tested using 2 case-control association studies. In addition, the regulatory effects of single-nucleotide polymorphism rs1800796 (-572C > G) on IL-6 production in plasma and CD14(+) monocyte cultures stimulated with a Mycobacterium tuberculosis (M. tuberculosis) product were assessed. Results The rs1800796 polymorphism is associated with increased resistance to tuberculosis (odds ratio [OR], 0.771; 95% confidential interval, .684-.870). The rs1800796GG genotype is strongly associated with reduced risk to tuberculosis (OR, 0.621; 95% CI, .460-.838). Interestingly, CD14(+) monocytes isolated from individuals with rs1800796GG genotype produced significantly less IL-6 in response to M. tuberculosis 19-kDa lipoprotein than those with CC or CG genotype. Conclusions We identified a genetic polymorphism in the IL-6 promoter that regulates cytokine production and host resistance to pulmonary tuberculosis in Chinese populations.
Persistent Identifierhttp://hdl.handle.net/10722/148735
ISSN
2013 Impact Factor: 5.778
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Eleven-Fifth Mega-Scientific Project on the "prevention and treatment of AIDS, viral hepatitis and other infectious diseases"2008ZX10003-005
Natural Science Foundation of China30872258
81172732
Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Food and Health Bureau of Hong Kong10091262
Funding Information:

This work was supported by Eleven-Fifth Mega-Scientific Project on the "prevention and treatment of AIDS, viral hepatitis and other infectious diseases" (2008ZX10003-005), the Natural Science Foundation of China (grants 30872258 and 81172732), the Intramural Research Program, Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, National Institutes of Health (to C. G. F.), and the Food and Health Bureau of Hong Kong (10091262 to J. W.).

Grants

 

DC FieldValueLanguage
dc.contributor.authorZhang, G-
dc.contributor.authorZhou, B-
dc.contributor.authorWang, W-
dc.contributor.authorZhang, M-
dc.contributor.authorZhao, Y-
dc.contributor.authorWang, Z-
dc.contributor.authorYang, L-
dc.contributor.authorZhai, j-
dc.contributor.authorFeng, CG-
dc.contributor.authorWang, JJ-
dc.contributor.authorChen, X-
dc.date.accessioned2012-05-30T03:56:53Z-
dc.date.available2012-05-30T03:56:53Z-
dc.date.issued2012-
dc.identifier.citationJournal of Infectious Diseases, 2012, v. 205 n. 11, p. 1697-1704-
dc.identifier.issn0022-1899-
dc.identifier.urihttp://hdl.handle.net/10722/148735-
dc.description.abstractBackground Genetic variation influences susceptibility or resistance to tuberculosis. Interleukin 6 (IL-6) contributes to protection against tuberculosis in mice. However, its role in regulating susceptibility or resistance to tuberculosis in humans is unclear. Methods Genotyping of polymorphisms in IL-6 and IL-6R (CD126) genes was performed in 2 independent cohorts, an experimental population (495 cases and 358 controls) and a validation population (1383 cases and 1149 controls). The associations of the variants with tuberculosis were tested using 2 case-control association studies. In addition, the regulatory effects of single-nucleotide polymorphism rs1800796 (-572C > G) on IL-6 production in plasma and CD14(+) monocyte cultures stimulated with a Mycobacterium tuberculosis (M. tuberculosis) product were assessed. Results The rs1800796 polymorphism is associated with increased resistance to tuberculosis (odds ratio [OR], 0.771; 95% confidential interval, .684-.870). The rs1800796GG genotype is strongly associated with reduced risk to tuberculosis (OR, 0.621; 95% CI, .460-.838). Interestingly, CD14(+) monocytes isolated from individuals with rs1800796GG genotype produced significantly less IL-6 in response to M. tuberculosis 19-kDa lipoprotein than those with CC or CG genotype. Conclusions We identified a genetic polymorphism in the IL-6 promoter that regulates cytokine production and host resistance to pulmonary tuberculosis in Chinese populations.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org-
dc.relation.ispartofJournal of Infectious Diseases-
dc.titleA functional single-nucleotide polymorphism in the promoter of the gene encoding interleukin 6 is associated with susceptibility to tuberculosisen_US
dc.typeArticleen_US
dc.identifier.emailWang, JJ: junwen@hkucc.hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/infdis/jis266-
dc.identifier.pmid22457277-
dc.identifier.pmcidPMC3415858-
dc.identifier.scopuseid_2-s2.0-84861045821-
dc.identifier.hkuros208296-
dc.identifier.volume205-
dc.identifier.issue11-
dc.identifier.spage1697-
dc.identifier.epage1704-
dc.identifier.isiWOS:000304065600014-
dc.publisher.placeUnited States-
dc.relation.projectA Novel Hidden Markov Model to Predict microRNAs and their Targets Simultaneously and its Application to the Epstein-Barr virus-

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