Article: A functional single-nucleotide polymorphism in the promoter of the gene encoding interleukin 6 is associated with susceptibility to tuberculosis

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TitleA functional single-nucleotide polymorphism in the promoter of the gene encoding interleukin 6 is associated with susceptibility to tuberculosis
AuthorsZhang, G2
Zhou, B2
Wang, W2 4
Zhang, M2
Zhao, Y4
Wang, Z2
Yang, L2
Zhai, j2
Feng, CG3
Wang, JJ1
Chen, X2
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
CitationJournal of Infectious Diseases, 2012, v. 205 n. 11, p. 1697-1704 [How to Cite?]
DOI: http://dx.doi.org/10.1093/infdis/jis266
AbstractBackground Genetic variation influences susceptibility or resistance to tuberculosis. Interleukin 6 (IL-6) contributes to protection against tuberculosis in mice. However, its role in regulating susceptibility or resistance to tuberculosis in humans is unclear. Methods Genotyping of polymorphisms in IL-6 and IL-6R (CD126) genes was performed in 2 independent cohorts, an experimental population (495 cases and 358 controls) and a validation population (1383 cases and 1149 controls). The associations of the variants with tuberculosis were tested using 2 case-control association studies. In addition, the regulatory effects of single-nucleotide polymorphism rs1800796 (-572C > G) on IL-6 production in plasma and CD14(+) monocyte cultures stimulated with a Mycobacterium tuberculosis (M. tuberculosis) product were assessed. Results The rs1800796 polymorphism is associated with increased resistance to tuberculosis (odds ratio [OR], 0.771; 95% confidential interval, .684-.870). The rs1800796GG genotype is strongly associated with reduced risk to tuberculosis (OR, 0.621; 95% CI, .460-.838). Interestingly, CD14(+) monocytes isolated from individuals with rs1800796GG genotype produced significantly less IL-6 in response to M. tuberculosis 19-kDa lipoprotein than those with CC or CG genotype. Conclusions We identified a genetic polymorphism in the IL-6 promoter that regulates cytokine production and host resistance to pulmonary tuberculosis in Chinese populations.
ISSN0022-1899
2011 Impact Factor: 6.41
2011 SCImago Journal Rankings: 0.831
DOIhttp://dx.doi.org/10.1093/infdis/jis266
PubMed Central IDPMC3415858
GrantsA Novel Hidden Markov Model to Predict microRNAs and their Targets Simultaneously and its Application to the Epstein-Barr virus
DC Field
Value
dc.contributor.authorZhang, G
dc.contributor.authorZhou, B
dc.contributor.authorWang, W
dc.contributor.authorZhang, M
dc.contributor.authorZhao, Y
dc.contributor.authorWang, Z
dc.contributor.authorYang, L
dc.contributor.authorZhai, j
dc.contributor.authorFeng, CG
dc.contributor.authorWang, JJ
dc.contributor.authorChen, X
dc.date.accessioned2012-05-30T03:56:53Z
dc.date.available2012-05-30T03:56:53Z
dc.date.issued2012
dc.description.abstractBackground Genetic variation influences susceptibility or resistance to tuberculosis. Interleukin 6 (IL-6) contributes to protection against tuberculosis in mice. However, its role in regulating susceptibility or resistance to tuberculosis in humans is unclear. Methods Genotyping of polymorphisms in IL-6 and IL-6R (CD126) genes was performed in 2 independent cohorts, an experimental population (495 cases and 358 controls) and a validation population (1383 cases and 1149 controls). The associations of the variants with tuberculosis were tested using 2 case-control association studies. In addition, the regulatory effects of single-nucleotide polymorphism rs1800796 (-572C > G) on IL-6 production in plasma and CD14(+) monocyte cultures stimulated with a Mycobacterium tuberculosis (M. tuberculosis) product were assessed. Results The rs1800796 polymorphism is associated with increased resistance to tuberculosis (odds ratio [OR], 0.771; 95% confidential interval, .684-.870). The rs1800796GG genotype is strongly associated with reduced risk to tuberculosis (OR, 0.621; 95% CI, .460-.838). Interestingly, CD14(+) monocytes isolated from individuals with rs1800796GG genotype produced significantly less IL-6 in response to M. tuberculosis 19-kDa lipoprotein than those with CC or CG genotype. Conclusions We identified a genetic polymorphism in the IL-6 promoter that regulates cytokine production and host resistance to pulmonary tuberculosis in Chinese populations.
dc.description.grantA Novel Hidden Markov Model to Predict microRNAs and their Targets Simultaneously and its Application to the Epstein-Barr virus
dc.description.grantcode103716
dc.description.naturelink_to_OA_fulltext
dc.identifier.citationJournal of Infectious Diseases, 2012, v. 205 n. 11, p. 1697-1704 [How to Cite?]
DOI: http://dx.doi.org/10.1093/infdis/jis266
dc.identifier.doihttp://dx.doi.org/10.1093/infdis/jis266
dc.identifier.epage1704
dc.identifier.hkuros208296
dc.identifier.isiWOS:000304065600014
Funding AgencyGrant Number
Eleven-Fifth Mega-Scientific Project on the "prevention and treatment of AIDS, viral hepatitis and other infectious diseases"2008ZX10003-005
Natural Science Foundation of China30872258
81172732
Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Food and Health Bureau of Hong Kong10091262
Funding Information:

This work was supported by Eleven-Fifth Mega-Scientific Project on the "prevention and treatment of AIDS, viral hepatitis and other infectious diseases" (2008ZX10003-005), the Natural Science Foundation of China (grants 30872258 and 81172732), the Intramural Research Program, Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, National Institutes of Health (to C. G. F.), and the Food and Health Bureau of Hong Kong (10091262 to J. W.).

dc.identifier.issn0022-1899
2011 Impact Factor: 6.41
2011 SCImago Journal Rankings: 0.831
dc.identifier.issue11
dc.identifier.pmcidPMC3415858
dc.identifier.pmid22457277
dc.identifier.scopuseid_2-s2.0-84861045821
dc.identifier.spage1697
dc.identifier.urihttp://hdl.handle.net/10722/148735
dc.identifier.volume205
dc.languageeng
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Infectious Diseases
dc.titleA functional single-nucleotide polymorphism in the promoter of the gene encoding interleukin 6 is associated with susceptibility to tuberculosis
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Shenzhen People's Hospital
  3. National Institute of Allergy and Infectious Diseases
  4. South China Agricultural University