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Article: A functional single-nucleotide polymorphism in the promoter of the gene encoding interleukin 6 is associated with susceptibility to tuberculosis
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TitleA functional single-nucleotide polymorphism in the promoter of the gene encoding interleukin 6 is associated with susceptibility to tuberculosis
 
AuthorsZhang, G2
Zhou, B2
Wang, W2 4
Zhang, M2
Zhao, Y4
Wang, Z2
Yang, L2
Zhai, j2
Feng, CG3
Wang, JJ1
Chen, X2
 
Issue Date2012
 
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
 
CitationJournal of Infectious Diseases, 2012, v. 205 n. 11, p. 1697-1704 [How to Cite?]
DOI: http://dx.doi.org/10.1093/infdis/jis266
 
AbstractBackground Genetic variation influences susceptibility or resistance to tuberculosis. Interleukin 6 (IL-6) contributes to protection against tuberculosis in mice. However, its role in regulating susceptibility or resistance to tuberculosis in humans is unclear. Methods Genotyping of polymorphisms in IL-6 and IL-6R (CD126) genes was performed in 2 independent cohorts, an experimental population (495 cases and 358 controls) and a validation population (1383 cases and 1149 controls). The associations of the variants with tuberculosis were tested using 2 case-control association studies. In addition, the regulatory effects of single-nucleotide polymorphism rs1800796 (-572C > G) on IL-6 production in plasma and CD14(+) monocyte cultures stimulated with a Mycobacterium tuberculosis (M. tuberculosis) product were assessed. Results The rs1800796 polymorphism is associated with increased resistance to tuberculosis (odds ratio [OR], 0.771; 95% confidential interval, .684-.870). The rs1800796GG genotype is strongly associated with reduced risk to tuberculosis (OR, 0.621; 95% CI, .460-.838). Interestingly, CD14(+) monocytes isolated from individuals with rs1800796GG genotype produced significantly less IL-6 in response to M. tuberculosis 19-kDa lipoprotein than those with CC or CG genotype. Conclusions We identified a genetic polymorphism in the IL-6 promoter that regulates cytokine production and host resistance to pulmonary tuberculosis in Chinese populations.
 
ISSN0022-1899
2012 Impact Factor: 5.848
2012 SCImago Journal Rankings: 2.723
 
DOIhttp://dx.doi.org/10.1093/infdis/jis266
 
PubMed Central IDPMC3415858
 
ISI Accession Number IDWOS:000304065600014
Funding AgencyGrant Number
Eleven-Fifth Mega-Scientific Project on the "prevention and treatment of AIDS, viral hepatitis and other infectious diseases"2008ZX10003-005
Natural Science Foundation of China30872258
81172732
Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Food and Health Bureau of Hong Kong10091262
Funding Information:

This work was supported by Eleven-Fifth Mega-Scientific Project on the "prevention and treatment of AIDS, viral hepatitis and other infectious diseases" (2008ZX10003-005), the Natural Science Foundation of China (grants 30872258 and 81172732), the Intramural Research Program, Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, National Institutes of Health (to C. G. F.), and the Food and Health Bureau of Hong Kong (10091262 to J. W.).

 
GrantsA Novel Hidden Markov Model to Predict microRNAs and their Targets Simultaneously and its Application to the Epstein-Barr virus
 
DC FieldValue
dc.contributor.authorZhang, G
 
dc.contributor.authorZhou, B
 
dc.contributor.authorWang, W
 
dc.contributor.authorZhang, M
 
dc.contributor.authorZhao, Y
 
dc.contributor.authorWang, Z
 
dc.contributor.authorYang, L
 
dc.contributor.authorZhai, j
 
dc.contributor.authorFeng, CG
 
dc.contributor.authorWang, JJ
 
dc.contributor.authorChen, X
 
dc.date.accessioned2012-05-30T03:56:53Z
 
dc.date.available2012-05-30T03:56:53Z
 
dc.date.issued2012
 
dc.description.abstractBackground Genetic variation influences susceptibility or resistance to tuberculosis. Interleukin 6 (IL-6) contributes to protection against tuberculosis in mice. However, its role in regulating susceptibility or resistance to tuberculosis in humans is unclear. Methods Genotyping of polymorphisms in IL-6 and IL-6R (CD126) genes was performed in 2 independent cohorts, an experimental population (495 cases and 358 controls) and a validation population (1383 cases and 1149 controls). The associations of the variants with tuberculosis were tested using 2 case-control association studies. In addition, the regulatory effects of single-nucleotide polymorphism rs1800796 (-572C > G) on IL-6 production in plasma and CD14(+) monocyte cultures stimulated with a Mycobacterium tuberculosis (M. tuberculosis) product were assessed. Results The rs1800796 polymorphism is associated with increased resistance to tuberculosis (odds ratio [OR], 0.771; 95% confidential interval, .684-.870). The rs1800796GG genotype is strongly associated with reduced risk to tuberculosis (OR, 0.621; 95% CI, .460-.838). Interestingly, CD14(+) monocytes isolated from individuals with rs1800796GG genotype produced significantly less IL-6 in response to M. tuberculosis 19-kDa lipoprotein than those with CC or CG genotype. Conclusions We identified a genetic polymorphism in the IL-6 promoter that regulates cytokine production and host resistance to pulmonary tuberculosis in Chinese populations.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationJournal of Infectious Diseases, 2012, v. 205 n. 11, p. 1697-1704 [How to Cite?]
DOI: http://dx.doi.org/10.1093/infdis/jis266
 
dc.identifier.doihttp://dx.doi.org/10.1093/infdis/jis266
 
dc.identifier.epage1704
 
dc.identifier.hkuros208296
 
dc.identifier.isiWOS:000304065600014
Funding AgencyGrant Number
Eleven-Fifth Mega-Scientific Project on the "prevention and treatment of AIDS, viral hepatitis and other infectious diseases"2008ZX10003-005
Natural Science Foundation of China30872258
81172732
Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Food and Health Bureau of Hong Kong10091262
Funding Information:

This work was supported by Eleven-Fifth Mega-Scientific Project on the "prevention and treatment of AIDS, viral hepatitis and other infectious diseases" (2008ZX10003-005), the Natural Science Foundation of China (grants 30872258 and 81172732), the Intramural Research Program, Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, National Institutes of Health (to C. G. F.), and the Food and Health Bureau of Hong Kong (10091262 to J. W.).

 
dc.identifier.issn0022-1899
2012 Impact Factor: 5.848
2012 SCImago Journal Rankings: 2.723
 
dc.identifier.issue11
 
dc.identifier.pmcidPMC3415858
 
dc.identifier.pmid22457277
 
dc.identifier.scopuseid_2-s2.0-84861045821
 
dc.identifier.spage1697
 
dc.identifier.urihttp://hdl.handle.net/10722/148735
 
dc.identifier.volume205
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Infectious Diseases
 
dc.relation.projectA Novel Hidden Markov Model to Predict microRNAs and their Targets Simultaneously and its Application to the Epstein-Barr virus
 
dc.titleA functional single-nucleotide polymorphism in the promoter of the gene encoding interleukin 6 is associated with susceptibility to tuberculosis
 
dc.typeArticle
 
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<item><contributor.author>Zhang, G</contributor.author>
<contributor.author>Zhou, B</contributor.author>
<contributor.author>Wang, W</contributor.author>
<contributor.author>Zhang, M</contributor.author>
<contributor.author>Zhao, Y</contributor.author>
<contributor.author>Wang, Z</contributor.author>
<contributor.author>Yang, L</contributor.author>
<contributor.author>Zhai, j</contributor.author>
<contributor.author>Feng, CG</contributor.author>
<contributor.author>Wang, JJ</contributor.author>
<contributor.author>Chen, X</contributor.author>
<date.accessioned>2012-05-30T03:56:53Z</date.accessioned>
<date.available>2012-05-30T03:56:53Z</date.available>
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<identifier.issn>0022-1899</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/148735</identifier.uri>
<description.abstract>Background Genetic variation influences susceptibility or resistance to tuberculosis. Interleukin 6 (IL-6) contributes to protection against tuberculosis in mice. However, its role in regulating susceptibility or resistance to tuberculosis in humans is unclear. Methods Genotyping of polymorphisms in IL-6 and IL-6R (CD126) genes was performed in 2 independent cohorts, an experimental population (495 cases and 358 controls) and a validation population (1383 cases and 1149 controls). The associations of the variants with tuberculosis were tested using 2 case-control association studies. In addition, the regulatory effects of single-nucleotide polymorphism rs1800796 (-572C &gt; G) on IL-6 production in plasma and CD14(+) monocyte cultures stimulated with a Mycobacterium tuberculosis (M. tuberculosis) product were assessed. Results The rs1800796 polymorphism is associated with increased resistance to tuberculosis (odds ratio [OR], 0.771; 95% confidential interval, .684-.870). The rs1800796GG genotype is strongly associated with reduced risk to tuberculosis (OR, 0.621; 95% CI, .460-.838). Interestingly, CD14(+) monocytes isolated from individuals with rs1800796GG genotype produced significantly less IL-6 in response to M. tuberculosis 19-kDa lipoprotein than those with CC or CG genotype. Conclusions We identified a genetic polymorphism in the IL-6 promoter that regulates cytokine production and host resistance to pulmonary tuberculosis in Chinese populations.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Shenzhen People's Hospital
  3. National Institute of Allergy and Infectious Diseases
  4. South China Agricultural University