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Conference Paper: Recent progress in the study of the intracellular functions of diadenosine polyphosphates
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TitleRecent progress in the study of the intracellular functions of diadenosine polyphosphates
 
AuthorsMclennan, AG1 1
Barnes, LD5
Blackburn, GM3
Brenner, C8
Guranowski, A9
Miller, AD7
Rovira, JM6
Rotllán, P4
Soria, B6
Tanner, JA7
Sillero, A2
 
KeywordsAp4a
Diphosphoinositol
Fhit
Stress
 
Issue Date2001
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34597
 
CitationDrug Development Research, 2001, v. 52 n. 1-2, p. 249-259 [How to Cite?]
DOI: http://dx.doi.org/10.1002/ddr.1122
 
AbstractRecent developments in the effort to understand the metabolism and function of the intracellular dinucleoside polyphosphates were described by nine speakers from some of the world's leading laboratories in this field in a workshop at the Purines 2000 International Symposium on Nucleosides and Nucleotides held in Madrid in July, 2000. Topics were wide-ranging and included phenotypic analyses of yeast mutants defective in enzymes of dinucleoside polyphosphate degradation, virally encoded catabolic enzymes, the structure and function of the Fhit tumor suppressor and Fhit-nitrilase fusion proteins and the relationship of Fhit to human diadenosine triphosphate hydrolase, site-directed mutagenesis of diadenosine tetraphosphate hydrolase, novel nucleotide analogs for studying hydrolase function, the synthesis of dinucleoside polyphosphates by ligases, and the possible roles of diadenosine tri- and tetraphosphates in insulin function and of diadenosine tetraphosphate in the heat-shock response of Escherichia coli. The results presented and the ensuing discussions showed that, while considerable progress is being made in the field, it still has the capacity to tease and frustrate and produce the unexpected result. © 2001 Wiley-Liss, Inc.
 
ISSN0272-4391
2012 Impact Factor: 0.869
 
DOIhttp://dx.doi.org/10.1002/ddr.1122
 
ISI Accession Number IDWOS:000168532400031
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorMclennan, AG
 
dc.contributor.authorBarnes, LD
 
dc.contributor.authorBlackburn, GM
 
dc.contributor.authorBrenner, C
 
dc.contributor.authorGuranowski, A
 
dc.contributor.authorMiller, AD
 
dc.contributor.authorRovira, JM
 
dc.contributor.authorRotllán, P
 
dc.contributor.authorSoria, B
 
dc.contributor.authorTanner, JA
 
dc.contributor.authorSillero, A
 
dc.date.accessioned2012-05-29T06:17:25Z
 
dc.date.available2012-05-29T06:17:25Z
 
dc.date.issued2001
 
dc.description.abstractRecent developments in the effort to understand the metabolism and function of the intracellular dinucleoside polyphosphates were described by nine speakers from some of the world's leading laboratories in this field in a workshop at the Purines 2000 International Symposium on Nucleosides and Nucleotides held in Madrid in July, 2000. Topics were wide-ranging and included phenotypic analyses of yeast mutants defective in enzymes of dinucleoside polyphosphate degradation, virally encoded catabolic enzymes, the structure and function of the Fhit tumor suppressor and Fhit-nitrilase fusion proteins and the relationship of Fhit to human diadenosine triphosphate hydrolase, site-directed mutagenesis of diadenosine tetraphosphate hydrolase, novel nucleotide analogs for studying hydrolase function, the synthesis of dinucleoside polyphosphates by ligases, and the possible roles of diadenosine tri- and tetraphosphates in insulin function and of diadenosine tetraphosphate in the heat-shock response of Escherichia coli. The results presented and the ensuing discussions showed that, while considerable progress is being made in the field, it still has the capacity to tease and frustrate and produce the unexpected result. © 2001 Wiley-Liss, Inc.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationDrug Development Research, 2001, v. 52 n. 1-2, p. 249-259 [How to Cite?]
DOI: http://dx.doi.org/10.1002/ddr.1122
 
dc.identifier.doihttp://dx.doi.org/10.1002/ddr.1122
 
dc.identifier.epage259
 
dc.identifier.isiWOS:000168532400031
 
dc.identifier.issn0272-4391
2012 Impact Factor: 0.869
 
dc.identifier.issue1-2
 
dc.identifier.scopuseid_2-s2.0-0035042508
 
dc.identifier.spage249
 
dc.identifier.urihttp://hdl.handle.net/10722/148704
 
dc.identifier.volume52
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34597
 
dc.publisher.placeUnited States
 
dc.relation.ispartofDrug Development Research
 
dc.relation.referencesReferences in Scopus
 
dc.subjectAp4a
 
dc.subjectDiphosphoinositol
 
dc.subjectFhit
 
dc.subjectStress
 
dc.titleRecent progress in the study of the intracellular functions of diadenosine polyphosphates
 
dc.typeConference_Paper
 
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Author Affiliations
  1. University of Liverpool
  2. Universidad Autónoma de Madrid, Facultad de Medicina
  3. University of Sheffield
  4. Universidad de la Laguna
  5. University of Texas Health Science Center at San Antonio
  6. Universidad Miguel Hernandez de Elche
  7. Imperial College London
  8. Thomas Jefferson University
  9. Uniwersytet Przyrodniczy w Poznaniu