Conference Paper: Recent progress in the study of the intracellular functions of diadenosine polyphosphates

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TitleRecent progress in the study of the intracellular functions of diadenosine polyphosphates
AuthorsMclennan, AG2
Barnes, LD4
Blackburn, GM3
Brenner, C9
Guranowski, A8
Miller, AD6
Rovira, JM7
Rotllán, P5
Soria, B7
Tanner, JA6
Sillero, A1
KeywordsAp4a
Diphosphoinositol
Fhit
Stress
Issue Date2001
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34597
CitationDrug Development Research, 2001, v. 52 n. 1-2, p. 249-259 [How to Cite?]
DOI: http://dx.doi.org/10.1002/ddr.1122
AbstractRecent developments in the effort to understand the metabolism and function of the intracellular dinucleoside polyphosphates were described by nine speakers from some of the world's leading laboratories in this field in a workshop at the Purines 2000 International Symposium on Nucleosides and Nucleotides held in Madrid in July, 2000. Topics were wide-ranging and included phenotypic analyses of yeast mutants defective in enzymes of dinucleoside polyphosphate degradation, virally encoded catabolic enzymes, the structure and function of the Fhit tumor suppressor and Fhit-nitrilase fusion proteins and the relationship of Fhit to human diadenosine triphosphate hydrolase, site-directed mutagenesis of diadenosine tetraphosphate hydrolase, novel nucleotide analogs for studying hydrolase function, the synthesis of dinucleoside polyphosphates by ligases, and the possible roles of diadenosine tri- and tetraphosphates in insulin function and of diadenosine tetraphosphate in the heat-shock response of Escherichia coli. The results presented and the ensuing discussions showed that, while considerable progress is being made in the field, it still has the capacity to tease and frustrate and produce the unexpected result. © 2001 Wiley-Liss, Inc.
ISSN0272-4391
2011 Impact Factor: 1.193
DOIhttp://dx.doi.org/10.1002/ddr.1122
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorMclennan, AG
dc.contributor.authorBarnes, LD
dc.contributor.authorBlackburn, GM
dc.contributor.authorBrenner, C
dc.contributor.authorGuranowski, A
dc.contributor.authorMiller, AD
dc.contributor.authorRovira, JM
dc.contributor.authorRotllán, P
dc.contributor.authorSoria, B
dc.contributor.authorTanner, JA
dc.contributor.authorSillero, A
dc.date.accessioned2012-05-29T06:17:25Z
dc.date.available2012-05-29T06:17:25Z
dc.date.issued2001
dc.description.abstractRecent developments in the effort to understand the metabolism and function of the intracellular dinucleoside polyphosphates were described by nine speakers from some of the world's leading laboratories in this field in a workshop at the Purines 2000 International Symposium on Nucleosides and Nucleotides held in Madrid in July, 2000. Topics were wide-ranging and included phenotypic analyses of yeast mutants defective in enzymes of dinucleoside polyphosphate degradation, virally encoded catabolic enzymes, the structure and function of the Fhit tumor suppressor and Fhit-nitrilase fusion proteins and the relationship of Fhit to human diadenosine triphosphate hydrolase, site-directed mutagenesis of diadenosine tetraphosphate hydrolase, novel nucleotide analogs for studying hydrolase function, the synthesis of dinucleoside polyphosphates by ligases, and the possible roles of diadenosine tri- and tetraphosphates in insulin function and of diadenosine tetraphosphate in the heat-shock response of Escherichia coli. The results presented and the ensuing discussions showed that, while considerable progress is being made in the field, it still has the capacity to tease and frustrate and produce the unexpected result. © 2001 Wiley-Liss, Inc.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationDrug Development Research, 2001, v. 52 n. 1-2, p. 249-259 [How to Cite?]
DOI: http://dx.doi.org/10.1002/ddr.1122
dc.identifier.doihttp://dx.doi.org/10.1002/ddr.1122
dc.identifier.epage259
dc.identifier.isiWOS:000168532400031
dc.identifier.issn0272-4391
2011 Impact Factor: 1.193
dc.identifier.issue1-2
dc.identifier.scopuseid_2-s2.0-0035042508
dc.identifier.spage249
dc.identifier.urihttp://hdl.handle.net/10722/148704
dc.identifier.volume52
dc.languageeng
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34597
dc.publisher.placeUnited States
dc.relation.ispartofDrug Development Research
dc.relation.referencesReferences in Scopus
dc.subjectAp4a
dc.subjectDiphosphoinositol
dc.subjectFhit
dc.subjectStress
dc.titleRecent progress in the study of the intracellular functions of diadenosine polyphosphates
dc.typeConference_Paper
Author Affiliations
  1. Universidad Autónoma de Madrid, Facultad de Medicina
  2. University of Liverpool
  3. University of Sheffield
  4. University of Texas Health Science Center at San Antonio
  5. Universidad de la Laguna
  6. Imperial College London
  7. Universidad Miguel Hernandez de Elche
  8. Uniwersytet Przyrodniczy w Poznaniu
  9. Thomas Jefferson University