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Article: A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection

TitleA critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection
Authors
KeywordsB cell
H5N1 influenza virus
IL-17
lung infection
Issue Date2011
PublisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html
Citation
Cellular And Molecular Immunology, 2011, v. 8 n. 6, p. 462-468 How to Cite?
AbstractInterleukin-17 (IL-17), a member of the IL-17 cytokine family, plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung. Although there is increasing evidence that IL-17 is involved in protective immunity against H1 and H3 influenza virus infections, little is known about the role of IL-17 in the highly pathogenic H5N1 influenza virus infection. In this study, we show that H5N1-infected IL-17 knockout (KO) mice exhibit markedly increased weight loss, more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type controls. Moreover, the frequency of B cells in the lung were substantially decreased in IL-17 KO mice after virus infection, which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 KO mice. Consistent with this observation, B cells from IL-17 KO mice exhibited a significant reduction in chemokine-mediated migration in culture. Taken together, these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice. © 2011 CSI and USTC. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/148655
ISSN
2014 Impact Factor: 4.112
ISI Accession Number ID
Funding AgencyGrant Number
Food and Health Bureau, Hong Kong SAR Government10091002
Funding Information:

We are grateful to Dr Yoichiro Iwakura (The University of Tokyo) for providing IL-17 KO mice. This work was supported by the Research Fund for the Control of Infectious Diseases (RFCID), Food and Health Bureau, Hong Kong SAR Government (No. 10091002). The authors declare no financial or commercial conflicts of interest.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorWang, Xen_HK
dc.contributor.authorChan, CCSen_HK
dc.contributor.authorYang, Men_HK
dc.contributor.authorDeng, Jen_HK
dc.contributor.authorPoon, VKMen_HK
dc.contributor.authorLeung, VHCen_HK
dc.contributor.authorKo, KHen_HK
dc.contributor.authorZhou, Jen_HK
dc.contributor.authorYung Yuen, Ken_HK
dc.contributor.authorZheng, BJen_HK
dc.contributor.authorLu, Len_HK
dc.date.accessioned2012-05-29T06:14:24Z-
dc.date.available2012-05-29T06:14:24Z-
dc.date.issued2011en_HK
dc.identifier.citationCellular And Molecular Immunology, 2011, v. 8 n. 6, p. 462-468en_HK
dc.identifier.issn1672-7681en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148655-
dc.description.abstractInterleukin-17 (IL-17), a member of the IL-17 cytokine family, plays a crucial role in mediating the immune response against extracellular bacteria and fungi in the lung. Although there is increasing evidence that IL-17 is involved in protective immunity against H1 and H3 influenza virus infections, little is known about the role of IL-17 in the highly pathogenic H5N1 influenza virus infection. In this study, we show that H5N1-infected IL-17 knockout (KO) mice exhibit markedly increased weight loss, more pronounced lung immunopathology and significantly reduced survival rates as compared with infected wild-type controls. Moreover, the frequency of B cells in the lung were substantially decreased in IL-17 KO mice after virus infection, which correlated with reduced CXCR5 expression in B cells and decreased CXCL13 production in the lung tissue of IL-17 KO mice. Consistent with this observation, B cells from IL-17 KO mice exhibited a significant reduction in chemokine-mediated migration in culture. Taken together, these findings demonstrate a critical role for IL-17 in mediating the recruitment of B cells to the site of pulmonary influenza virus infection in mice. © 2011 CSI and USTC. All rights reserved.en_HK
dc.languageengen_US
dc.publisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.htmlen_HK
dc.relation.ispartofCellular and Molecular Immunologyen_HK
dc.subjectB cellen_HK
dc.subjectH5N1 influenza virusen_HK
dc.subjectIL-17en_HK
dc.subjectlung infectionen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshB-Lymphocytes - Cytology - Immunology - Metabolismen_US
dc.subject.meshCell Movement - Immunologyen_US
dc.subject.meshChemokine Cxcl13 - Biosynthesis - Immunologyen_US
dc.subject.meshDown-Regulationen_US
dc.subject.meshFemaleen_US
dc.subject.meshFlow Cytometryen_US
dc.subject.meshGene Deletionen_US
dc.subject.meshHumansen_US
dc.subject.meshInfluenza A Virus, H5n1 Subtype - Immunology - Pathogenicityen_US
dc.subject.meshInfluenza, Human - Immunology - Pathology - Virologyen_US
dc.subject.meshInterleukin-17 - Deficiency - Genetics - Immunologyen_US
dc.subject.meshLung - Immunology - Pathology - Virologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57blen_US
dc.subject.meshMice, Knockouten_US
dc.subject.meshOrthomyxoviridae Infections - Immunology - Mortality - Pathology - Virologyen_US
dc.subject.meshReceptors, Cxcr5 - Biosynthesis - Immunologyen_US
dc.subject.meshSurvival Rateen_US
dc.subject.meshWeight Lossen_US
dc.titleA critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infectionen_HK
dc.typeArticleen_HK
dc.identifier.emailZhou, J:jiezhou@hku.hken_HK
dc.identifier.emailYung Yuen, K:kyyuen@hkucc.hku.hken_HK
dc.identifier.emailZheng, BJ:bzheng@hkucc.hku.hken_HK
dc.identifier.emailLu, L:liweilu@hkucc.hku.hken_HK
dc.identifier.authorityZhou, J=rp01412en_HK
dc.identifier.authorityYung Yuen, K=rp00366en_HK
dc.identifier.authorityZheng, BJ=rp00353en_HK
dc.identifier.authorityLu, L=rp00477en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/cmi.2011.38en_HK
dc.identifier.pmid21946434-
dc.identifier.scopuseid_2-s2.0-80055117444en_HK
dc.identifier.hkuros208186-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80055117444&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issue6en_HK
dc.identifier.spage462en_HK
dc.identifier.epage468en_HK
dc.identifier.isiWOS:000296758700005-
dc.publisher.placeChinaen_HK
dc.relation.projectThe role of IL-17 in modulating B cell functions duringin anti-viral immunity against H5N1 influenza infection in mice-
dc.identifier.scopusauthoridWang, X=54411517700en_HK
dc.identifier.scopusauthoridChan, CCS=16021156900en_HK
dc.identifier.scopusauthoridYang, M=35228247800en_HK
dc.identifier.scopusauthoridDeng, J=54410515000en_HK
dc.identifier.scopusauthoridPoon, VKM=6603703384en_HK
dc.identifier.scopusauthoridLeung, VHC=36612082100en_HK
dc.identifier.scopusauthoridKo, KH=7202688627en_HK
dc.identifier.scopusauthoridZhou, J=7405550443en_HK
dc.identifier.scopusauthoridYung Yuen, K=36078079100en_HK
dc.identifier.scopusauthoridZheng, BJ=7201780588en_HK
dc.identifier.scopusauthoridLu, L=7403963552en_HK

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