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Article: Changes of iron stores and duodenal transepithelial iron transfer during regular exercise in rats

TitleChanges of iron stores and duodenal transepithelial iron transfer during regular exercise in rats
Authors
Issue Date2011
PublisherHumana Press, Inc. The Journal's website is located at http://www.springer.com/humana+press/biochemistry/journal/12011
Citation
Biological Trace Element Research, 2011, v. 143 n. 2, p. 1044-1053 How to Cite?
AbstractIt is unclear whether regular exercise depletes body iron stores and how exercise regulates iron absorption. In this study, growing female Sprague-Dawley rats were fed a high-iron diet (300 mg iron/kg) and subjected to swimming for 1, 3, or 12 months. Their body weight, liver nonheme iron content (NHI), spleen NHI, blood hemoglobin (Hb) concentration, hematocrit (Hct), and kinetics of 59Fe transfer across isolated duodenal segments were then compared with sedentary controls. The main results were as follows: exercise for 1 month enhanced the transepithelial 59Fe transfer and increased liver NHI content and Hb concentration; exercise for 3 months inhibited transepithelial 59Fe transfer without affecting the liver and spleen NHI content, Hb concentration, and Hct; exercise for 12 months did not affect these parameters as compared with the corresponding sedentary controls; and the changes in transepithelial iron transfer were not associated with basolateral iron transfer. Our findings demonstrated that chronic, regular exercise in growing rats with a high dietary iron content does not deplete iron stores in the liver and spleen and may possibly enhance or inhibit duodenal iron absorption and even maintain duodenal iron absorption at the sedentary level, at least, in part depending on growth. © 2010 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/148651
ISSN
2015 Impact Factor: 1.798
2015 SCImago Journal Rankings: 0.652
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China30270639
30570894
Jiangsu Science and Technology Department, ChinaBS2003022
Innovative Research Groups Foundation of the Jiangsu University, China
Funding Information:

This work was funded by research grants from the National Natural Science Foundation of China (30270639 and 30570894), the Jiangsu Science and Technology Department, China (BS2003022), and the Innovative Research Groups Foundation of the Jiangsu University, China.

References

 

DC FieldValueLanguage
dc.contributor.authorChe, LLen_US
dc.contributor.authorXiao, DSen_US
dc.contributor.authorXu, HXen_US
dc.contributor.authorLu, Len_US
dc.date.accessioned2012-05-29T06:14:23Z-
dc.date.available2012-05-29T06:14:23Z-
dc.date.issued2011en_US
dc.identifier.citationBiological Trace Element Research, 2011, v. 143 n. 2, p. 1044-1053en_US
dc.identifier.issn0163-4984en_US
dc.identifier.urihttp://hdl.handle.net/10722/148651-
dc.description.abstractIt is unclear whether regular exercise depletes body iron stores and how exercise regulates iron absorption. In this study, growing female Sprague-Dawley rats were fed a high-iron diet (300 mg iron/kg) and subjected to swimming for 1, 3, or 12 months. Their body weight, liver nonheme iron content (NHI), spleen NHI, blood hemoglobin (Hb) concentration, hematocrit (Hct), and kinetics of 59Fe transfer across isolated duodenal segments were then compared with sedentary controls. The main results were as follows: exercise for 1 month enhanced the transepithelial 59Fe transfer and increased liver NHI content and Hb concentration; exercise for 3 months inhibited transepithelial 59Fe transfer without affecting the liver and spleen NHI content, Hb concentration, and Hct; exercise for 12 months did not affect these parameters as compared with the corresponding sedentary controls; and the changes in transepithelial iron transfer were not associated with basolateral iron transfer. Our findings demonstrated that chronic, regular exercise in growing rats with a high dietary iron content does not deplete iron stores in the liver and spleen and may possibly enhance or inhibit duodenal iron absorption and even maintain duodenal iron absorption at the sedentary level, at least, in part depending on growth. © 2010 Springer Science+Business Media, LLC.en_US
dc.languageengen_US
dc.publisherHumana Press, Inc. The Journal's website is located at http://www.springer.com/humana+press/biochemistry/journal/12011-
dc.relation.ispartofBiological Trace Element Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Transporten_US
dc.subject.meshBody Weight - Physiologyen_US
dc.subject.meshDietary Supplementsen_US
dc.subject.meshDuodenum - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshHematocriten_US
dc.subject.meshHemoglobins - Metabolismen_US
dc.subject.meshIntestinal Absorption - Physiologyen_US
dc.subject.meshIron - Administration & Dosage - Metabolismen_US
dc.subject.meshLiver - Metabolismen_US
dc.subject.meshPhysical Conditioning, Animal - Physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSpleen - Metabolismen_US
dc.titleChanges of iron stores and duodenal transepithelial iron transfer during regular exercise in ratsen_US
dc.typeArticleen_US
dc.identifier.emailLu, L:liweilu@hkucc.hku.hken_US
dc.identifier.authorityLu, L=rp00477en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s12011-010-8919-3en_US
dc.identifier.pmid21174168-
dc.identifier.scopuseid_2-s2.0-80054771959en_US
dc.identifier.hkuros208187-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80054771959&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume143en_US
dc.identifier.issue2en_US
dc.identifier.spage1044en_US
dc.identifier.epage1053en_US
dc.identifier.isiWOS:000295609300044-
dc.publisher.placeUnited Statesen_US
dc.identifier.citeulike8670791-

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