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Article: Pluronic L-81 ameliorates diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer protein

TitlePluronic L-81 ameliorates diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer protein
Authors
KeywordsAnimal models
db/db mice
Diabetes
Microsomal triglyceride protein
Pluronic L-81
Issue Date2009
PublisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
Citation
World Journal Of Gastroenterology, 2009, v. 15 n. 24, p. 2987-2994 How to Cite?
AbstractAim: To test whether oral L-81 treatment could improve the condition of mice with diabetes and to investigate how L-81 regulates microsomal triglyceride transfer protein (MTP) activity in the liver. Methods: Genetically diabetic (db/db) mice were fed on chow supplemented with or without L-81 for 4 wk. The body weight, plasma glucose level, plasma lipid profile, and adipocyte volume of the db/db mice were assessed after treatment. Toxicity of L-81 was also evaluated. To understand the molecular mechanism, HepG2 cells were treated with L-81 and the effects on apolipoprotein B (apoB) secretion and mRNA level of the MTP gene were assessed. Results: Treatment of db/db mice with L-81 significantly reduced and nearly normalized their body weight, hyperphagia and polydipsia. L-81 also markedly decreased the fasting plasma glucose level, improved glucose tolerance, and attenuated the elevated levels of plasma cholesterol and triglyceride. At the effective dosage, little toxicity was observed. Treatment of HepG2 cells with L-81 not only inhibited apoB secretion, but also significantly decreased the mRNA level of the MTP gene. Similar to the action of insulin, L-81 exerted its effect on the MTP promoter. Conclusion: L-81 represents a promising candidate in the development of a selective insulin-mimetic molecule and an anti-diabetic agent. © 2009 The WJG Press and Baishideng. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/148608
ISSN
2015 Impact Factor: 2.787
2015 SCImago Journal Rankings: 1.076
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WSen_HK
dc.contributor.authorLu, LWen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorKo, OKHen_HK
dc.contributor.authorChow, BKCen_HK
dc.contributor.authorHe, MLen_HK
dc.contributor.authorNg, SSen_HK
dc.contributor.authorYeung, CMen_HK
dc.contributor.authorLiu, CCen_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorLin, MCen_HK
dc.date.accessioned2012-05-29T06:14:05Z-
dc.date.available2012-05-29T06:14:05Z-
dc.date.issued2009en_HK
dc.identifier.citationWorld Journal Of Gastroenterology, 2009, v. 15 n. 24, p. 2987-2994en_HK
dc.identifier.issn1007-9327en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148608-
dc.description.abstractAim: To test whether oral L-81 treatment could improve the condition of mice with diabetes and to investigate how L-81 regulates microsomal triglyceride transfer protein (MTP) activity in the liver. Methods: Genetically diabetic (db/db) mice were fed on chow supplemented with or without L-81 for 4 wk. The body weight, plasma glucose level, plasma lipid profile, and adipocyte volume of the db/db mice were assessed after treatment. Toxicity of L-81 was also evaluated. To understand the molecular mechanism, HepG2 cells were treated with L-81 and the effects on apolipoprotein B (apoB) secretion and mRNA level of the MTP gene were assessed. Results: Treatment of db/db mice with L-81 significantly reduced and nearly normalized their body weight, hyperphagia and polydipsia. L-81 also markedly decreased the fasting plasma glucose level, improved glucose tolerance, and attenuated the elevated levels of plasma cholesterol and triglyceride. At the effective dosage, little toxicity was observed. Treatment of HepG2 cells with L-81 not only inhibited apoB secretion, but also significantly decreased the mRNA level of the MTP gene. Similar to the action of insulin, L-81 exerted its effect on the MTP promoter. Conclusion: L-81 represents a promising candidate in the development of a selective insulin-mimetic molecule and an anti-diabetic agent. © 2009 The WJG Press and Baishideng. All rights reserved.en_HK
dc.languageengen_US
dc.publisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htmen_HK
dc.relation.ispartofWorld Journal of Gastroenterologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAnimal modelsen_HK
dc.subjectdb/db miceen_HK
dc.subjectDiabetesen_HK
dc.subjectMicrosomal triglyceride proteinen_HK
dc.subjectPluronic L-81en_HK
dc.subject.meshAnimalsen_US
dc.subject.meshCarrier Proteins - Genetics - Metabolismen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCholesterol - Blooden_US
dc.subject.meshDiabetes Mellitus, Experimental - Drug Therapy - Metabolism - Physiopathologyen_US
dc.subject.meshDrinking - Drug Effectsen_US
dc.subject.meshEating - Drug Effectsen_US
dc.subject.meshGene Expression Regulation - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshHypoglycemic Agents - Pharmacology - Therapeutic Useen_US
dc.subject.meshLiver - Cytology - Drug Effects - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57blen_US
dc.subject.meshPoloxamer - Pharmacology - Therapeutic Useen_US
dc.subject.meshSurface-Active Agents - Pharmacology - Therapeutic Useen_US
dc.subject.meshThiazolidinediones - Pharmacology - Therapeutic Useen_US
dc.subject.meshTriglycerides - Blooden_US
dc.subject.meshWeight Loss - Drug Effectsen_US
dc.titlePluronic L-81 ameliorates diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer proteinen_HK
dc.typeArticleen_HK
dc.identifier.emailLu, LW: liweilu@hkucc.hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.emailNg, SS: ssmng@hku.hken_HK
dc.identifier.emailLin, MC: mcllin@hkucc.hku.hken_HK
dc.identifier.authorityLu, LW=rp00477en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.identifier.authorityNg, SS=rp00767en_HK
dc.identifier.authorityLin, MC=rp00746en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.3748/wjg.15.2987en_HK
dc.identifier.pmid19554651-
dc.identifier.pmcidPMC2702106-
dc.identifier.scopuseid_2-s2.0-67651245168en_HK
dc.identifier.hkuros157251-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67651245168&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue24en_HK
dc.identifier.spage2987en_HK
dc.identifier.epage2994en_HK
dc.identifier.isiWOS:000267496100005-
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridAu, WS=7202383097en_HK
dc.identifier.scopusauthoridLu, LW=7403963552en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridKo, OKH=8119962000en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK
dc.identifier.scopusauthoridHe, ML=35080389700en_HK
dc.identifier.scopusauthoridNg, SS=7403358718en_HK
dc.identifier.scopusauthoridYeung, CM=7201354151en_HK
dc.identifier.scopusauthoridLiu, CC=23492742300en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.scopusauthoridLin, MC=7404816359en_HK

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